BDBM50443165 CHEMBL3085828::US8674100, 22
SMILES: CC(C)(N1CCOCC1)c1ccc(NC(=O)c2ncc([nH]2)C#N)c(c1)C1=CCC(C)(C)CC1
InChI Key: InChIKey=BPOAALXUMAXZIT-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Macrophage colony-stimulating factor 1 receptor (c-Fms) (Mus musculus (Mouse)) | BDBM50443165 (CHEMBL3085828 | US8674100, 22) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Janssen Pharmaceutica, N.V. US Patent | Assay Description A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-... | US Patent US8674100 (2014) BindingDB Entry DOI: 10.7270/Q23777CF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony-stimulating factor 1 receptor (c-Fms) (Mus musculus (Mouse)) | BDBM50443165 (CHEMBL3085828 | US8674100, 22) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL | Assay Description Inhibition of FMS in mouse BMDM cells | Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony stimulating factor receptor (Homo sapiens (Human)) | BDBM50443165 (CHEMBL3085828 | US8674100, 22) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Research& Development LLC Curated by ChEMBL | Assay Description Inhibition of FMS (unknown origin) | Bioorg Med Chem Lett 23: 6363-9 (2013) Article DOI: 10.1016/j.bmcl.2013.09.061 BindingDB Entry DOI: 10.7270/Q2MP54RH | |||||||||||
More data for this Ligand-Target Pair |