BDBM50446143 CHEMBL3108897

SMILES: [#6]-[#16]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@H]-1-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6]-1=O)-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](-[#7])=O

InChI Key: InChIKey=XQSBANOJNRJJIQ-PCXPZXRNSA-N

Data: 1 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50446143   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM50446143 (CHEMBL3108897) Show SMILES [#6]-[#16]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@H]-1-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6]-1=O)-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](-[#7])=O |r| Show InChI InChI=1S/C96H174N36O26S/c1-48(2)45-66(88(153)115-50(4)75(102)140)128-83(148)63(31-33-68(101)136)124-79(144)57(24-12-16-37-98)122-82(147)61(28-20-41-111-95(105)106)126-89(154)67-30-22-43-132(67)93(158)52(6)117-78(143)56(23-11-15-36-97)118-71(139)47-113-70(138)46-114-90(155)72(53(7)133)129-87(152)64-32-34-69(137)109-39-18-14-26-59(123-84(149)65(35-44-159-10)127-92(157)74(55(9)135)131-86(151)62(119-76(141)49(3)100)29-21-42-112-96(107)108)85(150)130-73(54(8)134)91(156)116-51(5)77(142)120-60(27-19-40-110-94(103)104)81(146)121-58(80(145)125-64)25-13-17-38-99/h48-67,72-74,133-135H,11-47,97-100H2,1-10H3,(H2,101,136)(H2,102,140)(H,109,137)(H,113,138)(H,114,155)(H,115,153)(H,116,156)(H,117,143)(H,118,139)(H,119,141)(H,120,142)(H,121,146)(H,122,147)(H,123,149)(H,124,144)(H,125,145)(H,126,154)(H,127,157)(H,128,148)(H,129,152)(H,130,150)(H,131,151)(H4,103,104,110)(H4,105,106,111)(H4,107,108,112)/t49-,50-,51-,52-,53+,54+,55+,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,72-,73-,74-/m0/s1	PDB MMDB Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	385	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Competitive inhibition of recombinant LSD1 (unknown origin) using H3K4Me2 peptide as substrate preincubated for 30 mins followed by substrate additio...				ACS Med Chem Lett 5: 29-33 (2014) Article DOI: 10.1021/ml4002997 BindingDB Entry DOI: 10.7270/Q2HT2QS9
					More data for this Ligand-Target Pair
REST corepressor 1 (Homo sapiens (Human))	BDBM50446143 (CHEMBL3108897) Show SMILES [#6]-[#16]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@H]-1-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6]-1=O)-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](-[#7])=O |r| Show InChI InChI=1S/C96H174N36O26S/c1-48(2)45-66(88(153)115-50(4)75(102)140)128-83(148)63(31-33-68(101)136)124-79(144)57(24-12-16-37-98)122-82(147)61(28-20-41-111-95(105)106)126-89(154)67-30-22-43-132(67)93(158)52(6)117-78(143)56(23-11-15-36-97)118-71(139)47-113-70(138)46-114-90(155)72(53(7)133)129-87(152)64-32-34-69(137)109-39-18-14-26-59(123-84(149)65(35-44-159-10)127-92(157)74(55(9)135)131-86(151)62(119-76(141)49(3)100)29-21-42-112-96(107)108)85(150)130-73(54(8)134)91(156)116-51(5)77(142)120-60(27-19-40-110-94(103)104)81(146)121-58(80(145)125-64)25-13-17-38-99/h48-67,72-74,133-135H,11-47,97-100H2,1-10H3,(H2,101,136)(H2,102,140)(H,109,137)(H,113,138)(H,114,155)(H,115,153)(H,116,156)(H,117,143)(H,118,139)(H,119,141)(H,120,142)(H,121,146)(H,122,147)(H,123,149)(H,124,144)(H,125,145)(H,126,154)(H,127,157)(H,128,148)(H,129,152)(H,130,150)(H,131,151)(H4,103,104,110)(H4,105,106,111)(H4,107,108,112)/t49-,50-,51-,52-,53+,54+,55+,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,72-,73-,74-/m0/s1	PDB GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibition of recombinant human LSD1/CoREST preincubated for 5 mins followed by ART-(N,N-dimethyl-K)-QTARKSTGGKAPRKQLA substrate addition measured af...				Eur J Med Chem 148: 210-220 (2018) Article DOI: 10.1016/j.ejmech.2018.01.098 BindingDB Entry DOI: 10.7270/Q2N0195V
					More data for this Ligand-Target Pair
Lysine-specific histone demethylase 1A (Homo sapiens (Human))	BDBM50446143 (CHEMBL3108897) Show SMILES [#6]-[#16]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7])-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@H]-1-[#6]-[#6]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6]-1=O)-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-1-[#6]-[#6]-[#6]-[#6@H]-1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](-[#7])=O |r| Show InChI InChI=1S/C96H174N36O26S/c1-48(2)45-66(88(153)115-50(4)75(102)140)128-83(148)63(31-33-68(101)136)124-79(144)57(24-12-16-37-98)122-82(147)61(28-20-41-111-95(105)106)126-89(154)67-30-22-43-132(67)93(158)52(6)117-78(143)56(23-11-15-36-97)118-71(139)47-113-70(138)46-114-90(155)72(53(7)133)129-87(152)64-32-34-69(137)109-39-18-14-26-59(123-84(149)65(35-44-159-10)127-92(157)74(55(9)135)131-86(151)62(119-76(141)49(3)100)29-21-42-112-96(107)108)85(150)130-73(54(8)134)91(156)116-51(5)77(142)120-60(27-19-40-110-94(103)104)81(146)121-58(80(145)125-64)25-13-17-38-99/h48-67,72-74,133-135H,11-47,97-100H2,1-10H3,(H2,101,136)(H2,102,140)(H,109,137)(H,113,138)(H,114,155)(H,115,153)(H,116,156)(H,117,143)(H,118,139)(H,119,141)(H,120,142)(H,121,146)(H,122,147)(H,123,149)(H,124,144)(H,125,145)(H,126,154)(H,127,157)(H,128,148)(H,129,152)(H,130,150)(H,131,151)(H4,103,104,110)(H4,105,106,111)(H4,107,108,112)/t49-,50-,51-,52-,53+,54+,55+,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,72-,73-,74-/m0/s1	PDB MMDB Reactome pathway KEGG B.MOAD GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina Curated by ChEMBL					Assay Description Inhibition of recombinant LSD1 (unknown origin) using di-methylated H3-K4 peptide as substrate incubated for 5 mins prior to substrate addition by fl...				ACS Med Chem Lett 5: 29-33 (2014) Article DOI: 10.1021/ml4002997 BindingDB Entry DOI: 10.7270/Q2HT2QS9
					More data for this Ligand-Target Pair