Found 3 hits for monomerid = 50465778 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50465778
(CHEMBL4287478)Show SMILES C[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C21H23F2NO/c1-15(16-8-4-2-5-9-16)24-20(25)19-14-21(22,23)13-12-18(19)17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,24,25)/t15-,18+,19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 3/5
(Homo sapiens (Human)) | BDBM50465778
(CHEMBL4287478)Show SMILES C[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C21H23F2NO/c1-15(16-8-4-2-5-9-16)24-20(25)19-14-21(22,23)13-12-18(19)17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,24,25)/t15-,18+,19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 400 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human Kv7.3/7.5 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 4
(Homo sapiens (Human)) | BDBM50465778
(CHEMBL4287478)Show SMILES C[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C21H23F2NO/c1-15(16-8-4-2-5-9-16)24-20(25)19-14-21(22,23)13-12-18(19)17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,24,25)/t15-,18+,19-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human Kv7.4 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this Ligand-Target Pair | |