BDBM50465906 CHEMBL4293307
SMILES: COc1ccc(cc1)N(CCCCN1CCC(O)(CC1)c1ccc(Cl)c(c1)C(F)(F)F)c1ccc(OC)cc1
InChI Key: InChIKey=DYLSSJRMONSQGQ-UHFFFAOYSA-N
Data: 20 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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D(2) dopamine receptor (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 417 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]N-methylspiperone from human dopamine D2 receptor expressed in stable fibroblast cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(3) dopamine receptor (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 437 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293T cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(4) dopamine receptor (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 459 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]N-methylspiperone from human dopamine D4 receptor by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 622 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]WIN35428 from human DAT expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1B) dopamine receptor (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 623 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in HEK293T cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2B (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 729 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human 5-HT2B receptor expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2C (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 740 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]Mesulergine from human 5-HT2C receptor expressed in HEK293FlpIN cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]Ketanserin from 5-HT2A receptor (unknown origin) by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 7 (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 949 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human 5-HT7A receptor expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]Citalopram from human SERT expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 6 (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Monoamine transporter (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]Nisoxetine from human NET expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 5A (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 4.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]LSD from human 5-HT5A receptor expressed in Flp-In CHO cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H1 receptor (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 7.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]Pyrilamine from human H1 receptor expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 8.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]DAMGO from human MOR expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]U69593 from KOR (unknown origin) expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
D(1A) dopamine receptor (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]DADLE from human DOR expressed in HEK cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serotonin (5-HT) receptor (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]5-CT from human 5-HT1D receptor expressed in HEK293T cells by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50465906 (CHEMBL4293307) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Texas Tech University Health Sciences Center Curated by ChEMBL | Assay Description Displacement of [3H]-Way100635 from human 5HT1A receptor expressed in stable CHO cell membranes by radioligand binding assay | Bioorg Med Chem Lett 28: 3652-3657 (2018) Article DOI: 10.1016/j.bmcl.2018.10.036 BindingDB Entry DOI: 10.7270/Q280558N | |||||||||||
More data for this Ligand-Target Pair |