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SMILES: [H][C@@]12CN(C[C@]1([H])[C@@H]2c1nccn1-c1ccccc1)C1CC2(C1)CCN(C2)c1cnccn1

InChI Key: InChIKey=RZCYQOFVUNBAHJ-XHTMSGLCSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502369   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human))	BDBM50502369 (CHEMBL4515088) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@@H]2c1nccn1-c1ccccc1)C1CC2(C1)CCN(C2)c1cnccn1 |r,wU:7.9,wD:5.6,1.0,(54.59,-22.58,;56.12,-22.72,;55.6,-24.17,;56.83,-25.11,;58.1,-24.24,;57.66,-22.75,;59.2,-22.66,;56.92,-21.41,;56.96,-19.87,;58.21,-18.99,;57.77,-17.52,;56.23,-17.48,;55.72,-18.94,;54.25,-19.39,;53.13,-18.33,;51.65,-18.77,;51.3,-20.27,;52.44,-21.33,;53.91,-20.88,;56.78,-26.66,;55.65,-27.7,;56.7,-28.83,;57.83,-27.76,;57.84,-29.87,;57.21,-31.27,;55.67,-31.1,;55.36,-29.59,;54.65,-32.24,;55.11,-33.69,;54.09,-34.83,;52.58,-34.5,;52.11,-33.04,;53.15,-31.91,)| Show InChI InChI=1S/C25H28N6/c1-2-4-18(5-3-1)31-11-9-28-24(31)23-20-15-30(16-21(20)23)19-12-25(13-19)6-10-29(17-25)22-14-26-7-8-27-22/h1-5,7-9,11,14,19-21,23H,6,10,12-13,15-17H2/t19?,20-,21+,23-,25?	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...				ACS Med Chem Lett 10: 941-948 (2019) Article DOI: 10.1021/acsmedchemlett.9b00106 BindingDB Entry DOI: 10.7270/Q2GM8BJH
					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50502369 (CHEMBL4515088) Show SMILES [H][C@@]12CN(C[C@]1([H])[C@@H]2c1nccn1-c1ccccc1)C1CC2(C1)CCN(C2)c1cnccn1 |r,wU:7.9,wD:5.6,1.0,(54.59,-22.58,;56.12,-22.72,;55.6,-24.17,;56.83,-25.11,;58.1,-24.24,;57.66,-22.75,;59.2,-22.66,;56.92,-21.41,;56.96,-19.87,;58.21,-18.99,;57.77,-17.52,;56.23,-17.48,;55.72,-18.94,;54.25,-19.39,;53.13,-18.33,;51.65,-18.77,;51.3,-20.27,;52.44,-21.33,;53.91,-20.88,;56.78,-26.66,;55.65,-27.7,;56.7,-28.83,;57.83,-27.76,;57.84,-29.87,;57.21,-31.27,;55.67,-31.1,;55.36,-29.59,;54.65,-32.24,;55.11,-33.69,;54.09,-34.83,;52.58,-34.5,;52.11,-33.04,;53.15,-31.91,)| Show InChI InChI=1S/C25H28N6/c1-2-4-18(5-3-1)31-11-9-28-24(31)23-20-15-30(16-21(20)23)19-12-25(13-19)6-10-29(17-25)22-14-26-7-8-27-22/h1-5,7-9,11,14,19-21,23H,6,10,12-13,15-17H2/t19?,20-,21+,23-,25?	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	420	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Agonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isopr...				ACS Med Chem Lett 10: 941-948 (2019) Article DOI: 10.1021/acsmedchemlett.9b00106 BindingDB Entry DOI: 10.7270/Q2GM8BJH
					More data for this Ligand-Target Pair