null

SMILES: ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3ccc(O)cc3)c2=O)cc1

InChI Key: InChIKey=PWUOLJLDIZJJPB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50507696   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 1 (Homo sapiens (Human))	BDBM50507696 (CHEMBL4462263) Show SMILES ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3ccc(O)cc3)c2=O)cc1 Show InChI InChI=1S/C24H21N3O5/c28-19-11-7-16(8-12-19)13-14-26-23(30)20-3-1-2-4-21(20)27(24(26)31)15-17-5-9-18(10-6-17)22(29)25-32/h1-12,28,32H,13-15H2,(H,25,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
AnnJi Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of human full-length recombinant HDAC1 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate af...				J Med Chem 62: 857-874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01590
					More data for this Ligand-Target Pair
Histone deacetylase 11 (Homo sapiens (Human))	BDBM50507696 (CHEMBL4462263) Show SMILES ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3ccc(O)cc3)c2=O)cc1 Show InChI InChI=1S/C24H21N3O5/c28-19-11-7-16(8-12-19)13-14-26-23(30)20-3-1-2-4-21(20)27(24(26)31)15-17-5-9-18(10-6-17)22(29)25-32/h1-12,28,32H,13-15H2,(H,25,29)	NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
AnnJi Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of human full-length recombinant HDAC11 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate a...				J Med Chem 62: 857-874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01590
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50507696 (CHEMBL4462263) Show SMILES ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3ccc(O)cc3)c2=O)cc1 Show InChI InChI=1S/C24H21N3O5/c28-19-11-7-16(8-12-19)13-14-26-23(30)20-3-1-2-4-21(20)27(24(26)31)15-17-5-9-18(10-6-17)22(29)25-32/h1-12,28,32H,13-15H2,(H,25,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	845	n/a	n/a	n/a	n/a	n/a	n/a
AnnJi Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of human full-length recombinant HDAC8 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKAcKAc as substrate ...				J Med Chem 62: 857-874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01590
					More data for this Ligand-Target Pair
Histone deacetylase 6 (Homo sapiens (Human))	BDBM50507696 (CHEMBL4462263) Show SMILES ONC(=O)c1ccc(Cn2c3ccccc3c(=O)n(CCc3ccc(O)cc3)c2=O)cc1 Show InChI InChI=1S/C24H21N3O5/c28-19-11-7-16(8-12-19)13-14-26-23(30)20-3-1-2-4-21(20)27(24(26)31)15-17-5-9-18(10-6-17)22(29)25-32/h1-12,28,32H,13-15H2,(H,25,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
AnnJi Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of human full-length recombinant HDAC6 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate af...				J Med Chem 62: 857-874 (2019) Article DOI: 10.1021/acs.jmedchem.8b01590
					More data for this Ligand-Target Pair