BDBM50507712 CHEMBL4438001

SMILES: Cc1ccc(cc1NC(=O)C1(CC1)c1ncnc2[nH]ccc12)C(=O)Nc1cccc(Cl)c1

InChI Key: InChIKey=OLTHOLXSEXZACQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50507712   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM50507712 (CHEMBL4438001) Show SMILES Cc1ccc(cc1NC(=O)C1(CC1)c1ncnc2[nH]ccc12)C(=O)Nc1cccc(Cl)c1 Show InChI InChI=1S/C24H20ClN5O2/c1-14-5-6-15(22(31)29-17-4-2-3-16(25)12-17)11-19(14)30-23(32)24(8-9-24)20-18-7-10-26-21(18)28-13-27-20/h2-7,10-13H,8-9H2,1H3,(H,29,31)(H,30,32)(H,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of human GST-tagged BRAF V600E mutant (416 to 766 residues) using human full length 6His-tagged MEK1 (K97R) as substrate preincubated for ...				Eur J Med Chem 163: 243-255 (2019) Article DOI: 10.1016/j.ejmech.2018.11.033
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