BindingDB PrimarySearch

BDBM50511478 CHEMBL4519003

SMILES: CCc1ccc(cc1-c1cc(C)cc(c1)-c1cnc2cnccn12)C(=O)Nc1cc(F)cc(c1)C(F)(F)F

InChI Key: InChIKey=SERAEYFDVQXTIX-UHFFFAOYSA-N

Data: 4 IC50 5 Kd

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50511478
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Bcr-Abl (Homo sapiens (Human))	BDBM50511478 (CHEMBL4519003) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of human recombinant full length His-tagged Bcr-Abl expressed in baculovirus expression system using tyrosine-2 peptide as substrate after...				ACS Med Chem Lett 11: 379-384 (2020) Article DOI: 10.1021/acsmedchemlett.9b00495
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50511478 (CHEMBL4519003) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged DDR1 catalytic domain (440 to 876 residues) expressed in baculovirus expression system using Fluorescein-p...				ACS Med Chem Lett 11: 379-384 (2020) Article DOI: 10.1021/acsmedchemlett.9b00495
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
Discoidin domain-containing receptor 2 (Homo sapiens (Human))	BDBM50511478 (CHEMBL4519003) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of recombinant human GST-tagged DDR2 cytoplasmic domain (427 to 855 residues) expressed in baculovirus expression system using Fluorescein...				ACS Med Chem Lett 11: 379-384 (2020) Article DOI: 10.1021/acsmedchemlett.9b00495
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
Discoidin domain-containing receptor 2 (Homo sapiens (Human))	BDBM50511478 (CHEMBL4519003) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length DDR2 (V555 to E855 residues) expressed in mammalian expression system after 1 hr by Kinomescan met...				ACS Med Chem Lett 11: 379-384 (2020) Article DOI: 10.1021/acsmedchemlett.9b00495
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity protein kinase TTK (Homo sapiens (Human))	BDBM50511478 (CHEMBL4519003) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Binding affinity to wild-type human partial length TTK (N505 to V798 residues) expressed in bacterial expression system after 1 hr by Kinomescan meth...				ACS Med Chem Lett 11: 379-384 (2020) Article DOI: 10.1021/acsmedchemlett.9b00495
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
Dual specificity protein kinase CLK1/CLK4 (Homo sapiens (Human))	BDBM50511478 (CHEMBL4519003) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Binding affinity to wild-type human partial length CLK4 (R135 to K481 residues) expressed in bacterial expression system after 1 hr by Kinomescan met...				ACS Med Chem Lett 11: 379-384 (2020) Article DOI: 10.1021/acsmedchemlett.9b00495
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50511478 (CHEMBL4519003) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Inhibition of human recombinant His-tagged c-Kit cytoplasmic domain (544 to 976 residues) expressed in baculovirus expression system using Ser/Thr 6 ...				ACS Med Chem Lett 11: 379-384 (2020) Article DOI: 10.1021/acsmedchemlett.9b00495
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
Epithelial discoidin domain-containing receptor 1 (Homo sapiens (Human))	BDBM50511478 (CHEMBL4519003) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Binding affinity to wild type human partial length DDR1 (R565 to V876 residues) expressed in bacterial expression system after 1 hr by Kinomescan met...				ACS Med Chem Lett 11: 379-384 (2020) Article DOI: 10.1021/acsmedchemlett.9b00495
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair
CaM kinase I delta (Homo sapiens (Human))	BDBM50511478 (CHEMBL4519003) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a
Jinan University Curated by ChEMBL					Assay Description Binding affinity to wild-type human partial length CAMK1D (M1 to K299 residues) expressed in bacterial expression system after 1 hr by Kinomescan met...				ACS Med Chem Lett 11: 379-384 (2020) Article DOI: 10.1021/acsmedchemlett.9b00495
Jinan University Curated by ChEMBL					More data for this Ligand-Target Pair