BDBM50514844 CHEMBL4473213
SMILES: CC(C)(C)c1cc(NC(=O)Cc2ccc(cc2)-n2cnc3cc(ccc23)-c2ccc(cc2)S(C)(=O)=O)no1
InChI Key: InChIKey=LMFNJXLDISVWLF-UHFFFAOYSA-N
Data: 13 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of recombinant human His-tagged VEGFR2 cytoplasmic domain (789 to 1356 residues) expressed in baculovirus expression system using peptide ... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of recombinant human His-tagged TRKA cytoplasmic domain (441 to 796 residues) expressed in baculovirus expression system using peptide sub... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae) | BDBM50514844 (CHEMBL4473213) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of human ERG expressed in HEK293 cells by patch clamp assay | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of RET isoform 15 C634R mutant (unknown origin) expressed in mouse BAF3 cells assessed as reduction in cell proliferation supplemented wit... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of RET isoform 9 M918T mutant in human MZ-CRC-1 cells assessed as reduction in cell proliferation supplemented with fresh medium containin... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coiled-coil domain-containing protein 6 (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of CCDC6/RET in human TPC1 cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for every ... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage colony stimulating factor receptor (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus expression system using peptide su... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of RET isoform 9 C634W mutant in human TT cells assessed as reduction in cell proliferation supplemented with fresh medium containing comp... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of RET isoform 9 C634R mutant (unknown origin) expressed in mouse NIH/3T3 cells assessed as reduction in cell proliferation supplemented w... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of RET isoform 15 M918T mutant (unknown origin) expressed in mouse BAF3 cells assessed as reduction in cell proliferation supplemented wit... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coiled-coil domain-containing protein 6 (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.670 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of CCDC6/RET in human LC2/ad cells assessed as reduction in cell proliferation supplemented with fresh medium containing compound for ever... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of recombinant human N-terminal GST/His-tagged RET V804M mutant (658 to 1114 residues) expressed in Sf9 insect cells using 5'FAM-EPLYWSFPA... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM50514844 (CHEMBL4473213) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Napoli "Federico II" Curated by ChEMBL | Assay Description Inhibition of recombinant human GST-tagged RET cytoplasmic domain (658 to 1114 residues) expressed in baculovirus expression system using 5'FAM-EPLYW... | J Med Chem 63: 4506-4516 (2020) Article DOI: 10.1021/acs.jmedchem.9b01336 | |||||||||||
More data for this Ligand-Target Pair |