| Reaction Details |
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 | Report a problem with these data |
| Target | Coiled-coil domain-containing protein 6 |
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| Ligand | BDBM50514844 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1858793 (CHEMBL4359522) |
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| IC50 | 0.670000±n/a nM |
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| Citation |  Moccia, M; Frett, B; Zhang, L; Lakkaniga, NR; Briggs, DC; Chauhan, R; Brescia, A; Federico, G; Yan, W; Santoro, M; McDonald, NQ; Li, HY; Carlomagno, F Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology. J Med Chem63:4506-4516 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coiled-coil domain-containing protein 6 |
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| Name: | Coiled-coil domain-containing protein 6 |
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| Synonyms: | CCDC6 | CCDC6_HUMAN | Coiled-coil domain-containing protein 6 | D10S170 | Papillary thyroid carcinoma-encoded protein | Protein H4 | TST1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53294.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109661 |
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| Residue: | 474 |
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| Sequence: | MADSASESDTDGAGGNSSSSAAMQSSCSSTSGGGGGGGGGGGGGKSGGIVISPFRLEELT
NRLASLQQENKVLKIELETYKLKCKALQEENRDLRKASVTIQARAEQEEEFISNTLFKKI
QALQKEKETLAVNYEKEEEFLTNELSRKLMQLQHEKAELEQHLEQEQEFQVNKLMKKIKK
LENDTISKQLTLEQLRREKIDLENTLEQEQEALVNRLWKRMDKLEAEKRILQEKLDQPVS
APPSPRDISMEIDSPENMMRHIRFLKNEVERLKKQLRAAQLQHSEKMAQYLEEERHMREE
NLRLQRKLQREMERREALCRQLSESESSLEMDDERYFNEMSAQGLRPRTVSSPIPYTPSP
SSSRPISPGLSYASHTVGFTPPTSLTRAGMSYYNSPGLHVQHMGTSHGITRPSPRRSNSP
DKFKRPTPPPSPNTQTPVQPPPPPPPPPMQPTVPSAATSQPTPSQHSAHPSSQP
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| BDBM50514844 |
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| n/a |
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| Name | BDBM50514844 |
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| Synonyms: | CHEMBL4473213 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28N4O4S |
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| Mol. Mass. | 528.622 |
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| SMILES | CC(C)(C)c1cc(NC(=O)Cc2ccc(cc2)-n2cnc3cc(ccc23)-c2ccc(cc2)S(C)(=O)=O)no1 |
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| Structure | 
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