BDBM50519884 CHEMBL4438380
SMILES: OC(=O)c1ccc(NCc2c(noc2-c2cccs2)-c2c(Cl)cccc2C(F)(F)F)cc1
InChI Key: InChIKey=OYQVVGFWCTZBLC-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Peroxisome proliferator-activated receptor (Homo sapiens (Human)) | BDBM50519884 (CHEMBL4438380) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universiteit Eindhoven Curated by ChEMBL | Assay Description Inverse agonist activity at His6-tagged PPARgamma LBD (unknown origin) assessed as inhibition of rosiglitazone-induced N-terminal biotinylated co-act... | J Med Chem 63: 241-259 (2020) Article DOI: 10.1021/acs.jmedchem.9b01372 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (RORC) (Homo sapiens (Human)) | BDBM50519884 (CHEMBL4438380) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.75E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universiteit Eindhoven Curated by ChEMBL | Assay Description Inverse agonist activity at human N-terminal His6-tagged RORgammat LBD (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) assessed as inh... | J Med Chem 63: 241-259 (2020) Article DOI: 10.1021/acs.jmedchem.9b01372 | |||||||||||
More data for this Ligand-Target Pair |