Found 6 hits for monomerid = 50520253 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
MAP kinase-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50520253
(CHEMBL4587832)Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(c1)C1COC1 Show InChI InChI=1S/C21H22N4O3/c1-13(2)28-20-6-14(3-4-19(20)21(22)26)15-5-16(8-23-7-15)17-9-24-25(10-17)18-11-27-12-18/h3-10,13,18H,11-12H2,1-2H3,(H2,22,26) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
A*STAR
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged MNK2 (unknown origin) (72 to 385 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN... |
J Med Chem 63: 621-637 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01582
BindingDB Entry DOI: 10.7270/Q27084T7 |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1/2
(Homo sapiens (Human)) | BDBM50520253
(CHEMBL4587832)Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(c1)C1COC1 Show InChI InChI=1S/C21H22N4O3/c1-13(2)28-20-6-14(3-4-19(20)21(22)26)15-5-16(8-23-7-15)17-9-24-25(10-17)18-11-27-12-18/h3-10,13,18H,11-12H2,1-2H3,(H2,22,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
A*STAR
Curated by ChEMBL
| Assay Description
Inhibition of MNK1/MNK2 in human HeLa cells overexpressing eIF4E assessed as reduction in eIF4E phosphorylation at Ser209 residue after 2 hrs by Alph... |
J Med Chem 63: 621-637 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01582
BindingDB Entry DOI: 10.7270/Q27084T7 |
More data for this
Ligand-Target Pair | |
MAP kinase-interacting serine/threonine-protein kinase 1
(Homo sapiens (Human)) | BDBM50520253
(CHEMBL4587832)Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(c1)C1COC1 Show InChI InChI=1S/C21H22N4O3/c1-13(2)28-20-6-14(3-4-19(20)21(22)26)15-5-16(8-23-7-15)17-9-24-25(10-17)18-11-27-12-18/h3-10,13,18H,11-12H2,1-2H3,(H2,22,26) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
A*STAR
Curated by ChEMBL
| Assay Description
Inhibition of N-terminal GST-tagged MNK1 (unknown origin) (37 to 341 residues) expressed in Escherichia coli BL21 (DE3) cells using 5-FAM-TATKSGSTTKN... |
J Med Chem 63: 621-637 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01582
BindingDB Entry DOI: 10.7270/Q27084T7 |
More data for this
Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50520253
(CHEMBL4587832)Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(c1)C1COC1 Show InChI InChI=1S/C21H22N4O3/c1-13(2)28-20-6-14(3-4-19(20)21(22)26)15-5-16(8-23-7-15)17-9-24-25(10-17)18-11-27-12-18/h3-10,13,18H,11-12H2,1-2H3,(H2,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
A*STAR
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by manual patch clamp method |
J Med Chem 63: 621-637 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01582
BindingDB Entry DOI: 10.7270/Q27084T7 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM50520253
(CHEMBL4587832)Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(c1)C1COC1 Show InChI InChI=1S/C21H22N4O3/c1-13(2)28-20-6-14(3-4-19(20)21(22)26)15-5-16(8-23-7-15)17-9-24-25(10-17)18-11-27-12-18/h3-10,13,18H,11-12H2,1-2H3,(H2,22,26) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
A*STAR
Curated by ChEMBL
| Assay Description
Inhibition of CYP3A4 (unknown origin) |
J Med Chem 63: 621-637 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01582
BindingDB Entry DOI: 10.7270/Q27084T7 |
More data for this
Ligand-Target Pair | |
Cytochrome P450 2D6
(Homo sapiens (Human)) | BDBM50520253
(CHEMBL4587832)Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(c1)C1COC1 Show InChI InChI=1S/C21H22N4O3/c1-13(2)28-20-6-14(3-4-19(20)21(22)26)15-5-16(8-23-7-15)17-9-24-25(10-17)18-11-27-12-18/h3-10,13,18H,11-12H2,1-2H3,(H2,22,26) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
A*STAR
Curated by ChEMBL
| Assay Description
Inhibition of CYP2D6 (unknown origin) |
J Med Chem 63: 621-637 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01582
BindingDB Entry DOI: 10.7270/Q27084T7 |
More data for this
Ligand-Target Pair | |
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