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Found 1 hit Enz. Inhib. hit(s) with Target = 'MAP kinase-interacting serine/threonine-protein kinase 1/2' and Ligand = 'BDBM50520253'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))		BDBM50520253
PNG
(CHEMBL4587832)
Show SMILES CC(C)Oc1cc(ccc1C(N)=O)-c1cncc(c1)-c1cnn(c1)C1COC1
Show InChI InChI=1S/C21H22N4O3/c1-13(2)28-20-6-14(3-4-19(20)21(22)26)15-5-16(8-23-7-15)17-9-24-25(10-17)18-11-27-12-18/h3-10,13,18H,11-12H2,1-2H3,(H2,22,26)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 200n/an/an/an/an/an/a



A*STAR

Curated by ChEMBL


Assay Description
Inhibition of MNK1/MNK2 in human HeLa cells overexpressing eIF4E assessed as reduction in eIF4E phosphorylation at Ser209 residue after 2 hrs by Alph...

J Med Chem 63: 621-637 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01582
BindingDB Entry DOI: 10.7270/Q27084T7
More data for this
Ligand-Target Pair