BDBM50520683 CHEMBL4476621
SMILES: Oc1ccccc1C(=O)NNC(=S)Nc1ccc(Cl)c(Cl)c1
InChI Key: InChIKey=FNTHJTUPRVAXFZ-UHFFFAOYSA-N
Data: 21 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor after 60 mins by scintillation counting analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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D-3-phosphoglycerate dehydrogenase (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human recombinant C-terminal His-tagged PHGDH (1 to 533 residues) expressed in Escherichia coli using 3-phosphoglycerate as substrate | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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Arginase-1 (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human recombinant Arg1 using L-arginine as substrate after 5 mins in presence of [guanidino-14C]-L-arginine by liquid scintillation cou... | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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Carbonic anhydrase 2 (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human carbonic anhydrase 2 using 4-nitrophenyl acetate as substrate after 20 mins by spectrophotometric analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GABA-A receptor; alpha-1/beta-2/gamma-2 (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Displacement of [3H]muscimol from recombinant human GABAalpha1beta2gamma2 measured after 120 mins by scintillation counting method | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human recombinant Lck using Ulight-Poly GAT[EAY(1:1:1)]n as substrate after 10 mins by LANCE analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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Monoglyceride lipase (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 363 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human MAGL | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human MAOA using kynuramine as substrate after 20 mins by spectrophotometric analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human recombinant PDE3A using [3H]cAMP after 20 mins by scintillation counting analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae) | BDBM50520683 (CHEMBL4476621) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Displacement of [3H]-Dofetilide from recombinant human ERG after 60 mins by scintillation counting analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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Peroxisome proliferator-activated receptor (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Displacement of [3H]WY 14643 from human recombinant PPARalpha receptor at 10 uM after 120 mins by scintillation counting analysis relative to control | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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Angiotensin-converting enzyme (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human recombinant ACE using Abz-FRK(Dnp)-P-OH as substrate after 30 mins by fluorimetric analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human IDO using L-tryptophan as substrate after 30 mins by Ehrlich's reagent based assay | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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D-alanine--D-alanine ligase (Enterococcus faecalis (strain ATCC 700802 / V583)) | BDBM50520683 (CHEMBL4476621) | MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of Enterococcus faecalis JH2-2 C-terminal 6His-tagged DdlB expressed in Escherichia coli LMG194 preincubated for 30 mins followed by subst... | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
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Acetylcholinesterase (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human recombinant acetylcholinesterase using acetylthiocholine as substrate after 30 mins by spectrophotometric analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclooxygenase (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human recombinant COX1 using arachidonic acid as substrate after 3 mins by fluorimetric analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Displacement of [125I]pirenzepine from human recombinant M1 receptor after 60 mins by scintillation counting analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Secretory phospholipase A2 (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human sPLA2 | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prothrombin (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.103 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human thrombin using Z-GPR-AMC as substrate after 30 mins by fluorimetric analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cannabinoid receptor 1 (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Displacement of [3H]CP 55940 from human recombinant CB1 receptor after 120 mins by scintillation counting analysis | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
L-lactate dehydrogenase A chain (Homo sapiens (Human)) | BDBM50520683 (CHEMBL4476621) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.77E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Catholique de Louvain (UCLouvain) Curated by ChEMBL | Assay Description Inhibition of human recombinant full-length LDHA using sodium pyruvate as substrate after 60 mins by resazurin dye-based assay | Eur J Med Chem 159: 324-338 (2018) Article DOI: 10.1016/j.ejmech.2018.09.067 | |||||||||||
More data for this Ligand-Target Pair |