BDBM50521628 CHEMBL4546279

SMILES: CCN1CCN(CC1)c1cc(Nc2ncc(s2)C#CCNC(=O)Nc2cc(CC)on2)ncn1

InChI Key: InChIKey=BXPNRAHVPHLRKY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50521628   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50521628 (CHEMBL4546279) Show SMILES CCN1CCN(CC1)c1cc(Nc2ncc(s2)C#CCNC(=O)Nc2cc(CC)on2)ncn1 Show InChI InChI=1S/C22H27N9O2S/c1-3-16-12-19(29-33-16)27-21(32)23-7-5-6-17-14-24-22(34-17)28-18-13-20(26-15-25-18)31-10-8-30(4-2)9-11-31/h12-15H,3-4,7-11H2,1-2H3,(H2,23,27,29,32)(H,24,25,26,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
National Health Research Institutes Curated by ChEMBL					Assay Description Inhibition of recombinant human N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) expressed in baculovirus infected...				J Med Chem 62: 3940-3957 (2019) Article DOI: 10.1021/acs.jmedchem.8b01845
					More data for this Ligand-Target Pair