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BDBM50525007 CHEMBL4440664

SMILES: OCCc1ccc(Nc2cc(nc3CCCc23)-c2cccc(Cl)c2)cc1

InChI Key: InChIKey=HZTUBWNGLIWXGF-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50525007   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))		BDBM50525007
PNG
(CHEMBL4440664)
Show SMILES OCCc1ccc(Nc2cc(nc3CCCc23)-c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C22H21ClN2O/c23-17-4-1-3-16(13-17)21-14-22(19-5-2-6-20(19)25-21)24-18-9-7-15(8-10-18)11-12-26/h1,3-4,7-10,13-14,26H,2,5-6,11-12H2,(H,24,25)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 562n/an/an/an/an/an/a



Tetra Discovery Partners, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...

J Med Chem 62: 4884-4901 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00193
More data for this
Ligand-Target Pair