BDBM50535041 CHEMBL1312860
SMILES: CNC(=O)c1cc(c[nH]1)C(=O)c1c(Cl)cccc1Cl
InChI Key: InChIKey=IMCVPHRDALQWTJ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM50535041 (CHEMBL1312860) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 3.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Inhibition of human DOTL1 (2 to 416 residues)-mediated methylation of nucleosome preincubated for 30 mins followed by addition of S-[methyl-3H-] aden... | ACS Med Chem Lett 7: 730-4 (2016) Article DOI: 10.1021/acsmedchemlett.6b00168 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Histone-lysine N-methyltransferase, H3 lysine-79 specific (Homo sapiens (Human)) | BDBM50535041 (CHEMBL1312860) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research Curated by ChEMBL | Assay Description Binding affinity to biotinylated Avi tagged human DoT1L (2 to 416 residues) by SPR analysis | ACS Med Chem Lett 7: 730-4 (2016) Article DOI: 10.1021/acsmedchemlett.6b00168 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |