null
SMILES: CN1CCC(CC1)n1cc(Nc2ncc3nnn(-c4ccc(F)cc4C#N)c3n2)cn1
InChI Key:
PDB links: 1 PDB ID matches this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 6 (Homo sapiens (Human)) | BDBM50553822 (CHEMBL4757911) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to wild-type human partial length ERK3 (M1 to P413 residues) expressed in bacterial expression system by kinomescan method | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127551 BindingDB Entry DOI: 10.7270/Q2057KKN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 6 (Homo sapiens (Human)) | BDBM50553822 (CHEMBL4757911) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 244 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant His6-GST fusion tagged ERK3 (1 to 365 residues) (unknown origin) expressed in Sf21 insect cells using MK5 K51A mutant as su... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127551 BindingDB Entry DOI: 10.7270/Q2057KKN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 6 (Homo sapiens (Human)) | BDBM50553822 (CHEMBL4757911) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of ERK3 (unknown origin) expressed in HEK293 cells cotransfected with nano-luciferase by NanoBRET assay | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127551 BindingDB Entry DOI: 10.7270/Q2057KKN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 6 (Homo sapiens (Human)) | BDBM50553822 (CHEMBL4757911) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant full length His6-GST fusion tagged ERK3 (1 to 721 residues) (unknown origin) using MK5 K51A mutant as substrate by ADP-Glo ... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127551 BindingDB Entry DOI: 10.7270/Q2057KKN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase 6 (Homo sapiens (Human)) | BDBM50553822 (CHEMBL4757911) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant His6-GST fusion tagged ERK3 (1 to 471 residues) (unknown origin) expressed in Sf21 insect cells using MK5 K51A mutant as su... | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127551 BindingDB Entry DOI: 10.7270/Q2057KKN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |