BindingDB PrimarySearch

Found 5 hits Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 6' and Ligand = 'BDBM50553822'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 6 (Homo sapiens (Human))	BDBM50553822 (CHEMBL4757911) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ERK3 (unknown origin) expressed in HEK293 cells cotransfected with nano-luciferase by NanoBRET assay				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127551 BindingDB Entry DOI: 10.7270/Q2057KKN
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 6 (Homo sapiens (Human))	BDBM50553822 (CHEMBL4757911) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant His6-GST fusion tagged ERK3 (1 to 471 residues) (unknown origin) expressed in Sf21 insect cells using MK5 K51A mutant as su...				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127551 BindingDB Entry DOI: 10.7270/Q2057KKN
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 6 (Homo sapiens (Human))	BDBM50553822 (CHEMBL4757911) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	177	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant full length His6-GST fusion tagged ERK3 (1 to 721 residues) (unknown origin) using MK5 K51A mutant as substrate by ADP-Glo ...				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127551 BindingDB Entry DOI: 10.7270/Q2057KKN
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 6 (Homo sapiens (Human))	BDBM50553822 (CHEMBL4757911) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	244	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant His6-GST fusion tagged ERK3 (1 to 365 residues) (unknown origin) expressed in Sf21 insect cells using MK5 K51A mutant as su...				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127551 BindingDB Entry DOI: 10.7270/Q2057KKN
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 6 (Homo sapiens (Human))	BDBM50553822 (CHEMBL4757911) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to wild-type human partial length ERK3 (M1 to P413 residues) expressed in bacterial expression system by kinomescan method				Citation and Details Article DOI: 10.1016/j.bmcl.2020.127551 BindingDB Entry DOI: 10.7270/Q2057KKN
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)