null

SMILES: [H][C@]1(COC(=O)OCC)O[C@@]([H])(Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@]([H])(O)[C@@]([H])(O)[C@]1([H])O

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50559516   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50559516 (GSK-189075 | GSK-189075A | GSK189075A | Remogliflo...) Show SMILES [H][C@]1(COC(=O)OCC)O[C@@]([H])(Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@]([H])(O)[C@@]([H])(O)[C@]1([H])O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist potency against adenosine A2B receptor of guinea pig thoracic aortic smooth muscle				Citation and Details
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50559516 (GSK-189075 | GSK-189075A | GSK189075A | Remogliflo...) Show SMILES [H][C@]1(COC(=O)OCC)O[C@@]([H])(Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@]([H])(O)[C@@]([H])(O)[C@]1([H])O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem		4.52E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist potency at cloned recombinant human adenosine A2B receptor transfected in CHO cells by cAMP assay				Citation and Details
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50559516 (GSK-189075 | GSK-189075A | GSK189075A | Remogliflo...) Show SMILES [H][C@]1(COC(=O)OCC)O[C@@]([H])(Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@]([H])(O)[C@@]([H])(O)[C@]1([H])O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00867 BindingDB Entry DOI: 10.7270/Q2FB570W
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50559516 (GSK-189075 | GSK-189075A | GSK189075A | Remogliflo...) Show SMILES [H][C@]1(COC(=O)OCC)O[C@@]([H])(Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@]([H])(O)[C@@]([H])(O)[C@]1([H])O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake				Citation and Details Article DOI: 10.1016/j.bmc.2021.116033 BindingDB Entry DOI: 10.7270/Q29G5RHZ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 2 (Homo sapiens (Human))	BDBM50559516 (GSK-189075 | GSK-189075A | GSK189075A | Remogliflo...) Show SMILES [H][C@]1(COC(=O)OCC)O[C@@]([H])(Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@]([H])(O)[C@@]([H])(O)[C@]1([H])O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.53E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake				Citation and Details Article DOI: 10.1016/j.bmc.2021.116033 BindingDB Entry DOI: 10.7270/Q29G5RHZ
					More data for this Ligand-Target Pair
Sodium/glucose cotransporter 1 (Homo sapiens (Human))	BDBM50559516 (GSK-189075 | GSK-189075A | GSK189075A | Remogliflo...) Show SMILES [H][C@]1(COC(=O)OCC)O[C@@]([H])(Oc2nn(C(C)C)c(C)c2Cc2ccc(OC(C)C)cc2)[C@]([H])(O)[C@@]([H])(O)[C@]1([H])O |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00867 BindingDB Entry DOI: 10.7270/Q2FB570W
					More data for this Ligand-Target Pair