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SMILES: Cc1cc2c(cnc(NC3CCN(CC3)C(=O)C(F)(F)CN)c2[nH]c1=O)C1=CCOCC1
InChI Key:
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transcription initiation factor TFIID subunit 1 (Homo sapiens (Human)) | BDBM50572130 (CHEMBL4864027) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet  | PC cid PC sid UniChem | Article PubMed | 0.794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human partial length TAF1 bromodomain 2 (D1521 to D1656 residues) expressed in bacterial expression system by BROMOscan assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00294 BindingDB Entry DOI: 10.7270/Q21V5JRX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain-containing protein 9 (Homo sapiens (Human)) | BDBM50572130 (CHEMBL4864027) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human partial length BRD9 (R130 to V259 residues) expressed in bacterial expression system measured by BROMOscan assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00294 BindingDB Entry DOI: 10.7270/Q21V5JRX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50572130 (CHEMBL4864027) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human partial length BRD4 BD2 (K333 to E460 residues) expressed in bacterial expression system by BROMOscan assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00294 BindingDB Entry DOI: 10.7270/Q21V5JRX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain adjacent to zinc finger domain protein 2B (Homo sapiens (Human)) | BDBM50572130 (CHEMBL4864027) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human partial length BAZ2B (S2054 to S2168 residues) expressed in bacterial expression system by BROMOscan assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00294 BindingDB Entry DOI: 10.7270/Q21V5JRX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Chromatin remodeling regulator CECR2 (Homo sapiens (Human)) | BDBM50572130 (CHEMBL4864027) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human partial length CECR2 (P423 to D543 residues) expressed in bacterial expression system by BROMOscan assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00294 BindingDB Entry DOI: 10.7270/Q21V5JRX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Peregrin (Homo sapiens (Human)) | BDBM50572130 (CHEMBL4864027) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human partial length BRPF1 (E627 to G740 residues) expressed in bacterial expression system by BROMOscan assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00294 BindingDB Entry DOI: 10.7270/Q21V5JRX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50572130 (CHEMBL4864027) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | <5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human partial length BRD4 BD1 (N44 to E168 residues) expressed in bacterial expression system by BROMOscan assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00294 BindingDB Entry DOI: 10.7270/Q21V5JRX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50572130 (CHEMBL4864027) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of BRD4 BD2 (unknown origin) measured by TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00294 BindingDB Entry DOI: 10.7270/Q21V5JRX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Transcription initiation factor TFIID subunit 1 (Homo sapiens (Human)) | BDBM50572130 (CHEMBL4864027) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of TAF1 bromodomain 2 (unknown origin) by TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00294 BindingDB Entry DOI: 10.7270/Q21V5JRX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Transcription initiation factor TFIID subunit 1 (Homo sapiens (Human)) | BDBM50572130 (CHEMBL4864027) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Displacement of Halo-tagged histone H4 from NanoLuc-tagged TAF1 bromodomain 2 (unknown origin) expressed in HEK293 cells measured after 4 to 6 hrs by... | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00294 BindingDB Entry DOI: 10.7270/Q21V5JRX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Bromodomain-containing protein 4 (Homo sapiens (Human)) | BDBM50572130 (CHEMBL4864027) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of BRD4 BD1 (unknown origin) by TR-FRET assay | Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00294 BindingDB Entry DOI: 10.7270/Q21V5JRX | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
