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SMILES: COc1cc(cc(OC)c1OC)-c1nc(SCc2ccc(Cl)cc2)nc(Sc2nnnn2C)c1C#N
InChI Key:
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DCN1-like protein 1 (Homo sapiens) | BDBM50584167 (CHEMBL5085822) | PDB UniProtKB/SwissProt GoogleScholar AffyNet  | Purchase MCE PC cid PC sid UniChem | Article PubMed | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to DCN1 (unknown origin) assessed as inhibitory constant | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DCN1-like protein 2 (Homo sapiens) | BDBM50584167 (CHEMBL5085822) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 1.88E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to DCN2 (unknown origin) assessed as inhibitory constant | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DCN1-like protein 4 (Homo sapiens) | BDBM50584167 (CHEMBL5085822) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 2.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to DCN4 (unknown origin) assessed as inhibitory constant | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DCN1-like protein 5 (Homo sapiens) | BDBM50584167 (CHEMBL5085822) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 2.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to DCN5 (unknown origin) assessed as inhibitory constant | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DCN1-like protein 3 (Homo sapiens) | BDBM50584167 (CHEMBL5085822) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | 3.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to DCN3 (unknown origin) assessed as inhibitory constant | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DCN1-like protein 1 (Homo sapiens) | BDBM50584167 (CHEMBL5085822) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of GST-tagged DCN1 (unknown origin) using AcUBE2M1-21 incubated for 30 mins by HTRF assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| DCN1-like protein 1 (Homo sapiens) | BDBM50584167 (CHEMBL5085822) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to extracellular DCN1 (unknown origin) assessed as dissociation constant incubated for upto 180 secs by label-free biolayer interfer... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01207 BindingDB Entry DOI: 10.7270/Q2JD51NJ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
