BDBM5147 (5Z)-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-pyrrol-2-yl]methylidene}-4-(piperidin-1-yl)-5H,6H,7H-pyrrolo[2,3-d]pyrimidin-6-one::pyrrolo[2,3-d]pyrimidin-6-one deriv. 29

SMILES: Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(N3CCCCC3)c12)C(=O)N1CCOCC1

InChI Key: InChIKey=VIJTXHKQZRDGPG-QINSGFPZSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 5147   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM5147 ((5Z)-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-py...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(N3CCCCC3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3/c1-14-11-17(22(30)28-7-9-31-10-8-28)25-16(14)12-15-18-19(26-21(15)29)23-13-24-20(18)27-5-3-2-4-6-27/h11-13,25H,2-10H2,1H3,(H,23,24,26,29)/b15-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM5147 ((5Z)-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-py...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(N3CCCCC3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3/c1-14-11-17(22(30)28-7-9-31-10-8-28)25-16(14)12-15-18-19(26-21(15)29)23-13-24-20(18)27-5-3-2-4-6-27/h11-13,25H,2-10H2,1H3,(H,23,24,26,29)/b15-12-	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5147 ((5Z)-5-{[3-methyl-5-(morpholin-4-ylcarbonyl)-1H-py...) Show SMILES Cc1cc([nH]c1\C=C1/C(=O)Nc2ncnc(N3CCCCC3)c12)C(=O)N1CCOCC1 Show InChI InChI=1S/C22H26N6O3/c1-14-11-17(22(30)28-7-9-31-10-8-28)25-16(14)12-15-18-19(26-21(15)29)23-13-24-20(18)27-5-3-2-4-6-27/h11-13,25H,2-10H2,1H3,(H,23,24,26,29)/b15-12-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
SUGEN, Inc.					Assay Description IC50 is the inhibitor concentration which inhibits 50% of EGF-R or PDGFR-beta kinase autophosphorylation activity. The assay was performed in 96-well...				Bioorg Med Chem Lett 12: 2153-7 (2002) Article DOI: 10.1016/s0960-894x(02)00364-5 BindingDB Entry DOI: 10.7270/Q200009N
					More data for this Ligand-Target Pair