BDBM5441 6-Thiazolylquinazoline 3::N-(1-benzyl-1H-indazol-5-yl)-6-(2-{[(2-methanesulfonylethyl)amino]methyl}-1,3-thiazol-4-yl)quinazolin-4-amine

SMILES: CS(=O)(=O)CCNCc1nc(cs1)-c1ccc2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c2c1

InChI Key: InChIKey=ZJAASMJOPRABKY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5441   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM5441 (6-Thiazolylquinazoline 3 | N-(1-benzyl-1H-indazol-...) Show SMILES CS(=O)(=O)CCNCc1nc(cs1)-c1ccc2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c2c1 Show InChI InChI=1S/C29H27N7O2S2/c1-40(37,38)12-11-30-16-28-35-26(18-39-28)21-7-9-25-24(14-21)29(32-19-31-25)34-23-8-10-27-22(13-23)15-33-36(27)17-20-5-3-2-4-6-20/h2-10,13-15,18-19,30H,11-12,16-17H2,1H3,(H,31,32,34)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	7.5	23
GlaxoSmithKline					Assay Description Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...				Bioorg Med Chem Lett 14: 111-4 (2004) Article DOI: 10.1016/j.bmcl.2003.10.010 BindingDB Entry DOI: 10.7270/Q2HQ3X4M
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM5441 (6-Thiazolylquinazoline 3 | N-(1-benzyl-1H-indazol-...) Show SMILES CS(=O)(=O)CCNCc1nc(cs1)-c1ccc2ncnc(Nc3ccc4n(Cc5ccccc5)ncc4c3)c2c1 Show InChI InChI=1S/C29H27N7O2S2/c1-40(37,38)12-11-30-16-28-35-26(18-39-28)21-7-9-25-24(14-21)29(32-19-31-25)34-23-8-10-27-22(13-23)15-33-36(27)17-20-5-3-2-4-6-20/h2-10,13-15,18-19,30H,11-12,16-17H2,1H3,(H,31,32,34)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	7.5	23
GlaxoSmithKline					Assay Description Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...				Bioorg Med Chem Lett 14: 111-4 (2004) Article DOI: 10.1016/j.bmcl.2003.10.010 BindingDB Entry DOI: 10.7270/Q2HQ3X4M
					More data for this Ligand-Target Pair