null
SMILES: [O-][N+](=O)c1ccc(cc1)N1C(=S)S\C(=C\c2ccc(Sc3ccc(Cl)cc3)o2)C1=O
InChI Key: InChIKey=OWBUIZNGKRRUNL-GZTJUZNOSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Coagulation factor VIII (Homo sapiens (Human)) | BDBM59163 (6789536) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.85E+3 | n/a | n/a | n/a | n/a | n/a | 37 |
University of Washington | Assay Description Inhibition of factor VIII C2 domain. | Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor VIII (Homo sapiens (Human)) | BDBM59163 (6789536) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.60E+3 | n/a | n/a | n/a | n/a | 7.9 | n/a |
University of Washington | Assay Description Inhibition of factor X activation assay. A commercially available chromogenic assay that measures the rate of factor X activation to measure inhibit... | Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Coagulation factor VIII (Homo sapiens (Human)) | BDBM59163 (6789536) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.81E+3 | n/a | n/a | n/a | n/a | 8.0 | n/a |
University of Washington | Assay Description Inhibition of factor VIII ELISA. The interaction between factor VIII and PS was measured by using an enzyme-linked immunoadsorbent assay (ELISA). | Chem Biol 11: 1413-22 (2004) Article DOI: 10.1016/j.chembiol.2004.08.006 BindingDB Entry DOI: 10.7270/Q29W0CX1 | |||||||||||
More data for this Ligand-Target Pair |