BDBM65501 8-pCP-cGMP::Cyclic GMP analogs::cGMP
SMILES: Nc1nc(=O)c2nc(Sc3ccc(Cl)cc3)n([C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O)c2[nH]1
InChI Key: InChIKey=ZDJHIEHUVPCEDK-IDTAVKCVSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
hPKG 1 beta (aa 1-351) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 163 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG 1 beta (aa 1-351) (G182E) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 328 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG 1 beta (aa 1-351) (G306E) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 4.20 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG 1 beta (aa 1-351) (G306E) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 7.70 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG 1 beta (aa 5-676) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 370 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG 1 beta (aa 5-676) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 249 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cGMP-dependent protein kinase 2 (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 257 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
cGMP-dependent protein kinase 2 (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 22 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG II 41−418 (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 96 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG II 41−418 (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 5 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG II 41−418 (G232E) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 184 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG II 41−418 (G232E) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 116 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG II 41−418 (G356E) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 50 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG 1 beta (aa 1-351) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 212 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG II 41−418 (G356E) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | <1 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
hPKG 1 beta (aa 1-351) (G182E) (Homo sapiens (Human)) | BDBM65501 (8-pCP-cGMP | Cyclic GMP analogs | cGMP) | PDB MMDB B.MOAD GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 206 | n/a | n/a | 7.0 | n/a |
Baylor College of Medicine | Assay Description Kinase activity was determined employing a microfluidic mobility-shift assay on a Caliper DeskTop Profiler (Caliper Life Sciences, PerkinElmer). The ... | ACS Chem Biol 12: 2388-2398 (2017) Article DOI: 10.1021/acschembio.7b00369 BindingDB Entry DOI: 10.7270/Q2930RB1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |