BDBM70646 US9693997, 173

SMILES: Nc1nc(Nc2cc(Cl)c(-c3ccc(cc3)S(=O)(=O)N[C@H]3C[C@H](O)C3)c(c2)C(F)(F)F)n[nH]1

InChI Key:

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 70646   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RNA polymerase (NS5B) (Hepatitis C virus (HCV))	BDBM70646 (US9693997, 173) Show SMILES Nc1nc(Nc2cc(Cl)c(-c3ccc(cc3)S(=O)(=O)N[C@H]3C[C@H](O)C3)c(c2)C(F)(F)F)n[nH]1 |r,wU:22.23,wD:20.20,$;;;;HN;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;$,(-9.04,3.89,;-7.5,3.89,;-6.6,5.14,;-5.13,4.66,;-3.8,5.43,;-2.47,4.66,;-1.13,5.43,;.2,4.66,;1.53,5.43,;.2,3.12,;1.53,2.35,;1.53,.81,;2.87,.04,;4.2,.81,;4.2,2.35,;2.87,3.12,;5.54,.04,;6.87,.81,;5.54,-1.5,;7.31,-.35,;7.71,-1.84,;6.94,-3.18,;8.27,-3.95,;8.67,-5.43,;9.04,-2.61,;-1.13,2.35,;-2.47,3.12,;-1.13,.81,;.2,.04,;-2.47,.04,;-2.62,1.21,;-5.13,3.12,;-6.6,2.65,)| Show InChI	PDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...				US Patent US9693997 (2017) BindingDB Entry DOI: 10.7270/Q2833Q56
					More data for this Ligand-Target Pair
HCV NS3-NS4A Serine Proteinase (Hepatitis C virus (HCV genotype 1a, isolate H))	BDBM70646 (US9693997, 173) Show SMILES Nc1nc(Nc2cc(Cl)c(-c3ccc(cc3)S(=O)(=O)N[C@H]3C[C@H](O)C3)c(c2)C(F)(F)F)n[nH]1 |r,wU:22.23,wD:20.20,$;;;;HN;;;;;;;;;;;;;;;HN;;;;;;;;;;;;;$,(-9.04,3.89,;-7.5,3.89,;-6.6,5.14,;-5.13,4.66,;-3.8,5.43,;-2.47,4.66,;-1.13,5.43,;.2,4.66,;1.53,5.43,;.2,3.12,;1.53,2.35,;1.53,.81,;2.87,.04,;4.2,.81,;4.2,2.35,;2.87,3.12,;5.54,.04,;6.87,.81,;5.54,-1.5,;7.31,-.35,;7.71,-1.84,;6.94,-3.18,;8.27,-3.95,;8.67,-5.43,;9.04,-2.61,;-1.13,2.35,;-2.47,3.12,;-1.13,.81,;.2,.04,;-2.47,.04,;-2.62,1.21,;-5.13,3.12,;-6.6,2.65,)| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a
HOFFMANN-LA ROCHE INC. US Patent					Assay Description Plasmids expressing HCV E1 and E2 envelope proteins of GT1a H77 strain (Proc Natl Acad Sci USA 1997 94:8738-43) or GT1b Con1 strain (Science 1999 285...				US Patent US9693997 (2017) BindingDB Entry DOI: 10.7270/Q2833Q56
					More data for this Ligand-Target Pair