BDBM7253 (3Z)-5-methoxy-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-c]pyridin-1-yl}methylidene)-2,3-dihydro-1H-indol-2-one::pyrrollylactam indolinone driv. 16a

SMILES: COc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1

InChI Key: InChIKey=YMLCUQPWYZHIPJ-GHXNOFRVSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 7253   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CDK2/CycE (Homo sapiens (Human))	BDBM7253 ((3Z)-5-methoxy-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,...) Show SMILES COc1ccc2NC(=O)\C(=C/c3[nH]cc4c3CCNC4=O)c2c1 Show InChI InChI=1S/C17H15N3O3/c1-23-9-2-3-14-11(6-9)12(17(22)20-14)7-15-10-4-5-18-16(21)13(10)8-19-15/h2-3,6-8,19H,4-5H2,1H3,(H,18,21)(H,20,22)/b12-7-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
					More data for this Ligand-Target Pair