BDBM7261 (3Z)-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-c]pyridin-1-yl}methylidene)-6-phenyl-2,3-dihydro-1H-indol-2-one::pyrrollylactam indolinone driv. 16n

SMILES: O=C1Nc2cc(ccc2\C1=C\c1[nH]cc2c1CCNC2=O)-c1ccccc1

InChI Key: InChIKey=XAOYZCFECWOXGY-BOPFTXTBSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 7261   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CDK2/CycE (Homo sapiens (Human))	BDBM7261 ((3Z)-3-({4-oxo-2H,4H,5H,6H,7H-pyrrolo[3,4-c]pyridi...) Show SMILES O=C1Nc2cc(ccc2\C1=C\c1[nH]cc2c1CCNC2=O)-c1ccccc1 Show InChI InChI=1S/C22H17N3O2/c26-21-18-12-24-19(16(18)8-9-23-21)11-17-15-7-6-14(10-20(15)25-22(17)27)13-4-2-1-3-5-13/h1-7,10-12,24H,8-9H2,(H,23,26)(H,25,27)/b17-11-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	7.4	22
SUGEN, Inc.					Assay Description For the assay, purified cdk/cyclin was added to polystyrene 96-well plates that were precoated with GST-Rb substrate in the presence of ATP. After i...				Bioorg Med Chem Lett 13: 1939-42 (2003) Article DOI: 10.1016/s0960-894x(03)00312-3 BindingDB Entry DOI: 10.7270/Q2HD7SW7
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