BDBM77015 (R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoisoindolin-2-yl)piperidine-2,6-dione::US9694015, 6.4R
SMILES: O=C1N(Cc2c1cccc2OCc1ccc(CN2CCOCC2)cc1)[C@@H]1CCC(=O)NC1=O
InChI Key: InChIKey=IXZOHGPZAQLIBH-OAQYLSRUSA-N
Data: 8 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Interleukin-6 (Homo sapiens (Human)) | BDBM77015 ((R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoi...) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glyceraldehyde-3-phosphate dehydrogenase cytosolic (Leishmania mexicana) | BDBM77015 ((R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoi...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
hIL-1beta (Homo sapiens (Human)) | BDBM77015 ((R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoi...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tumor necrosis factor (Homo sapiens (Human)) | BDBM77015 ((R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mediator of DNA damage checkpoint protein 1 (Homo sapiens (Human)) | BDBM77015 ((R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C motif chemokine 3 (Homo sapiens (Human)) | BDBM77015 ((R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C motif chemokine 4 (Homo sapiens (Human)) | BDBM77015 ((R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Granulocyte-macrophage colony-stimulating factor (Homo sapiens (Human)) | BDBM77015 ((R)-3-(4-((4-(morpholinomethyl)benzyl)-oxy)-1-oxoi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | 37 |
Celgene Corporation US Patent | Assay Description The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a 20° C. freezer p... | US Patent US9694015 (2017) BindingDB Entry DOI: 10.7270/Q2R49NZN | |||||||||||
More data for this Ligand-Target Pair |