BDBM80290 (8R)-7-[2-(4-chloranylphenoxy)ethanoyl]-3-[3-(2-methylprop-2-enoylamino)phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide::(8R)-7-[2-(4-chlorophenoxy)-1-oxoethyl]-3-[3-[(2-methyl-1-oxoprop-2-enyl)amino]phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide::(8R)-7-[2-(4-chlorophenoxy)acetyl]-3-(3-methacrylamidophenyl)-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide::(8R)-7-[2-(4-chlorophenoxy)acetyl]-3-[3-(2-methylprop-2-enoylamino)phenyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-8-carboxamide::MLS000561957::SMR000390644::cid_16745478

SMILES: CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)COc2ccc(Cl)cc2)C(N)=O)C1

InChI Key: InChIKey=SSSGETUBQMNOFY-JGKWMGOWSA-N

Data: 5 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 80290   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA dC->dU-editing enzyme APOBEC-3G (Homo sapiens (Human))	BDBM80290 ((8R)-7-[2-(4-chloranylphenoxy)ethanoyl]-3-[3-(2-me...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)COc2ccc(Cl)cc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C25H25ClN4O5/c1-15(2)24(33)28-18-5-3-4-16(10-18)20-11-25(35-29-20)12-21(23(27)32)30(14-25)22(31)13-34-19-8-6-17(26)7-9-19/h3-10,21H,1,11-14H2,2H3,(H2,27,32)(H,28,33)/t21-,25?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	7.21E+3	n/a	n/a	n/a	n/a	n/a	25
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2HQ3XD6
					More data for this Ligand-Target Pair
probable DNA dC->dU-editing enzyme APOBEC-3A (Homo sapiens (Human))	BDBM80290 ((8R)-7-[2-(4-chloranylphenoxy)ethanoyl]-3-[3-(2-me...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)COc2ccc(Cl)cc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C25H25ClN4O5/c1-15(2)24(33)28-18-5-3-4-16(10-18)20-11-25(35-29-20)12-21(23(27)32)30(14-25)22(31)13-34-19-8-6-17(26)7-9-19/h3-10,21H,1,11-14H2,2H3,(H2,27,32)(H,28,33)/t21-,25?/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	25
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2CZ35ND
					More data for this Ligand-Target Pair
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 (Homo sapiens (Human))	BDBM80290 ((8R)-7-[2-(4-chloranylphenoxy)ethanoyl]-3-[3-(2-me...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)COc2ccc(Cl)cc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C25H25ClN4O5/c1-15(2)24(33)28-18-5-3-4-16(10-18)20-11-25(35-29-20)12-21(23(27)32)30(14-25)22(31)13-34-19-8-6-17(26)7-9-19/h3-10,21H,1,11-14H2,2H3,(H2,27,32)(H,28,33)/t21-,25?/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	3.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2V986KM
					More data for this Ligand-Target Pair
DNA (cytosine-5)-methyltransferase 1 (DNMT1) (Homo sapiens (Human))	BDBM80290 ((8R)-7-[2-(4-chloranylphenoxy)ethanoyl]-3-[3-(2-me...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)COc2ccc(Cl)cc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C25H25ClN4O5/c1-15(2)24(33)28-18-5-3-4-16(10-18)20-11-25(35-29-20)12-21(23(27)32)30(14-25)22(31)13-34-19-8-6-17(26)7-9-19/h3-10,21H,1,11-14H2,2H3,(H2,27,32)(H,28,33)/t21-,25?/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	5.52E+3	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...				PubChem Bioassay (2012) BindingDB Entry DOI: 10.7270/Q2NC5ZRN
					More data for this Ligand-Target Pair
Apoptotic peptidase activating factor 1 (Homo sapiens (Human))	BDBM80290 ((8R)-7-[2-(4-chloranylphenoxy)ethanoyl]-3-[3-(2-me...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)COc2ccc(Cl)cc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C25H25ClN4O5/c1-15(2)24(33)28-18-5-3-4-16(10-18)20-11-25(35-29-20)12-21(23(27)32)30(14-25)22(31)13-34-19-8-6-17(26)7-9-19/h3-10,21H,1,11-14H2,2H3,(H2,27,32)(H,28,33)/t21-,25?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q2SB447H
					More data for this Ligand-Target Pair
Apoptotic peptidase activating factor 1 (Homo sapiens (Human))	BDBM80290 ((8R)-7-[2-(4-chloranylphenoxy)ethanoyl]-3-[3-(2-me...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)COc2ccc(Cl)cc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C25H25ClN4O5/c1-15(2)24(33)28-18-5-3-4-16(10-18)20-11-25(35-29-20)12-21(23(27)32)30(14-25)22(31)13-34-19-8-6-17(26)7-9-19/h3-10,21H,1,11-14H2,2H3,(H2,27,32)(H,28,33)/t21-,25?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	n/a	n/a	4.23E+3	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q29C6VXX
					More data for this Ligand-Target Pair
Caspase-9 (Homo sapiens (Human))	BDBM80290 ((8R)-7-[2-(4-chloranylphenoxy)ethanoyl]-3-[3-(2-me...) Show SMILES CC(=C)C(=O)Nc1cccc(c1)C1=NOC2(C[C@@H](N(C2)C(=O)COc2ccc(Cl)cc2)C(N)=O)C1 |t:13| Show InChI InChI=1S/C25H25ClN4O5/c1-15(2)24(33)28-18-5-3-4-16(10-18)20-11-25(35-29-20)12-21(23(27)32)30(14-25)22(31)13-34-19-8-6-17(26)7-9-19/h3-10,21H,1,11-14H2,2H3,(H2,27,32)(H,28,33)/t21-,25?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	9.82E+4	n/a	n/a	n/a	n/a	n/a	n/a
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBIMR, San Diego, C...				PubChem Bioassay (2011) BindingDB Entry DOI: 10.7270/Q25M647F
					More data for this Ligand-Target Pair