BDBM93135 PDE5 Inhibitor, 1

SMILES: COC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@H](N1)c1ccc(OC)cc1OC

InChI Key: InChIKey=SJSWGNOTMJXTHK-IEBWSBKVSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 93135   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM93135 (PDE5 Inhibitor, 1) Show SMILES COC(=O)[C@H]1Cc2c([nH]c3ccccc23)[C@H](N1)c1ccc(OC)cc1OC |r| Show InChI InChI=1S/C21H22N2O4/c1-25-12-8-9-14(18(10-12)26-2)19-20-15(11-17(23-19)21(24)27-3)13-6-4-5-7-16(13)22-20/h4-10,17,19,22-23H,11H2,1-3H3/t17-,19-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars		n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
German University in Cairo					Assay Description PDE activity was measured using a modification of the IMAP fluorescence polarization phosphodiesterase assay from Molecular Devices. The assay was m...				International Journal of Medicinal Chemistry 2011: 1-9 (2011) BindingDB Entry DOI: 10.7270/Q21R6P59
					More data for this Ligand-Target Pair