Enzyme Monomer Search

Marvin 2D Structure

Wt: 151.1 BDBM50200094 Purchase	Wt: 167.1 BDBM50200099 Purchase	Wt: 287.3 BDBM50181863	Wt: 183.1 BDBM50181897	Wt: 268.2 BDBM50181899
Wt: 287.3 BDBM50182023	Wt: 291.3 BDBM50182027	Wt: 241.2 BDBM50182028	Wt: 254.2 BDBM50181901	Wt: 257.2 BDBM50181515
Wt: 241.2 BDBM50181516	Wt: 227.2 BDBM50181517	Wt: 165.1 BDBM50497027 Purchase	Wt: 195.1 BDBM50497028	Wt: 151.1 BDBM50497031 Purchase

Displayed 1 to 15 (of 63 total ) | Next | Last >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 39 hits in this display
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Purine nucleoside phosphorylase (Rattus norvegicus)	BDBM50200094 (2-amino-1,9-dihydro-6H-purin-6-one \| CHEMBL219568 ...) Show SMILES Nc1nc2nc[nH]c2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Southern Research Institute Curated by ChEMBL					Assay Description Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP)				J Med Chem 37: 2477-80 (1994) BindingDB Entry DOI: 10.7270/Q21G0K9T
Southern Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50200094 (2-amino-1,9-dihydro-6H-purin-6-one \| CHEMBL219568 ...) Show SMILES Nc1nc2nc[nH]c2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Competitive inhibition of human erythrocyte purine nucleoside phosphorylase assessed as inhibition of guanosine phosphorylysis after 30 mins by Linew...				J Med Chem 21: 877-82 (1979) BindingDB Entry DOI: 10.7270/Q2DN46KH
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Polyphenol oxidase 2 (Agaricus bisporus (Common mushroom))	BDBM50200099 (2-Amino-1,7-dihydro-purine-6-thione \| 2-Amino-1,9-...) Show SMILES Nc1nc2nc[nH]c2c(=S)[nH]1 Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents		5.20E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50200099 (2-Amino-1,7-dihydro-purine-6-thione \| 2-Amino-1,9-...) Show SMILES Nc1nc2nc[nH]c2c(=S)[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL									Bioorg Med Chem Lett 15: 5211-7 (2005) Article DOI: 10.1021/acs.jmedchem.2c00303 BindingDB Entry DOI: 10.7270/Q2H70KWC
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50200099 (2-Amino-1,7-dihydro-purine-6-thione \| 2-Amino-1,9-...) Show SMILES Nc1nc2nc[nH]c2c(=S)[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL									Bioorg Med Chem Lett 15: 5211-7 (2005) Article DOI: 10.1021/acs.jmedchem.2c00303 BindingDB Entry DOI: 10.7270/Q2H70KWC
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50200099 (2-Amino-1,7-dihydro-purine-6-thione \| 2-Amino-1,9-...) Show SMILES Nc1nc2nc[nH]c2c(=S)[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL									Bioorg Med Chem Lett 15: 5211-7 (2005) Article DOI: 10.1021/acs.jmedchem.2c00303 BindingDB Entry DOI: 10.7270/Q2H70KWC
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Homo sapiens (Human))	BDBM50200094 (2-amino-1,9-dihydro-6H-purin-6-one \| CHEMBL219568 ...) Show SMILES Nc1nc2nc[nH]c2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for inhibition of purine nucleoside phosphorylase using human erythro lysate				J Med Chem 29: 2034-7 (1986) BindingDB Entry DOI: 10.7270/Q29P326Z
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Shiga toxin subunit A (Shigella dysenteriae)	BDBM50200094 (2-amino-1,9-dihydro-6H-purin-6-one \| CHEMBL219568 ...) Show SMILES Nc1nc2nc[nH]c2c(=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.15E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of Shigella dysenteriae type 1 Shiga toxin A subunit in African green monkey Vero cells assessed as inhibition of Stx-induced cytotoxicity...				J Med Chem 59: 10763-10773 (2016) Article DOI: 10.1021/acs.jmedchem.6b01517 BindingDB Entry DOI: 10.7270/Q2571DZG
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Ubiquitin carboxyl-terminal hydrolase 2 (Homo sapiens (Human))	BDBM50200099 (2-Amino-1,7-dihydro-purine-6-thione \| 2-Amino-1,9-...) Show SMILES Nc1nc2nc[nH]c2c(=S)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents		n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Replicase polyprotein 1ab (2019-nCoV)	BDBM50200099 (2-Amino-1,7-dihydro-purine-6-thione \| 2-Amino-1,9-...) Show SMILES Nc1nc2nc[nH]c2c(=S)[nH]1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL									Bioorg Med Chem Lett 15: 5211-7 (2005) Article DOI: 10.1021/acs.jmedchem.2c00303 BindingDB Entry DOI: 10.7270/Q2H70KWC
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Xanthine dehydrogenase/oxidase (Homo sapiens (Human))	BDBM50200099 (2-Amino-1,7-dihydro-purine-6-thione \| 2-Amino-1,9-...) Show SMILES Nc1nc2nc[nH]c2c(=S)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	9.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry and the Genomics Research Center Curated by ChEMBL					Assay Description Inhibition of human xanthine oxidase				Bioorg Med Chem 15: 3450-6 (2007) Article DOI: 10.1016/j.bmc.2007.03.010 BindingDB Entry DOI: 10.7270/Q2WD407G
					More data for this Ligand-Target Pair
Ricin (Ricinus communis)	BDBM50200094 (2-amino-1,9-dihydro-6H-purin-6-one \| CHEMBL219568 ...) Show SMILES Nc1nc2nc[nH]c2c(=O)[nH]1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Texas Curated by ChEMBL					Assay Description Inhibitory concentration against Enzymatic A chain of ricin (RTA) using Artemia salina ribosomes				J Med Chem 45: 90-8 (2001) BindingDB Entry DOI: 10.7270/Q2F190F7
University of Texas Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50181899 (CHEMBL3818814) Show SMILES CN(C)C(=O)CSc1nc2c(nc(N)[nH]c2=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5.30E+4	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (Staphylococcus aureus)	BDBM50181863 (CHEMBL3818011) Show SMILES Cc1ccccc1CSc1nc2c(nc(N)[nH]c2=O)[nH]1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	470	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Staphylococcus aureus HPPK in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (Staphylococcus aureus)	BDBM50182027 (CHEMBL3819387) Show SMILES Nc1nc2[nH]c(SCc3cccc(F)c3)nc2c(=O)[nH]1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Staphylococcus aureus HPPK in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (Staphylococcus aureus)	BDBM50182028 (CHEMBL3818744) Show SMILES COCCSc1nc2c(nc(N)[nH]c2=O)[nH]1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.76E+3	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Staphylococcus aureus HPPK in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (Staphylococcus aureus)	BDBM50181515 (CHEMBL3819144) Show SMILES Nc1nc2[nH]c(SCC(O)CO)nc2c(=O)[nH]1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.34E+4	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Staphylococcus aureus HPPK in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50181897 (CHEMBL178006) Show SMILES Nc1nc2[nH]c(S)nc2c(=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	1.60E+5	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (Staphylococcus aureus)	BDBM50181899 (CHEMBL3818814) Show SMILES CN(C)C(=O)CSc1nc2c(nc(N)[nH]c2=O)[nH]1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Staphylococcus aureus HPPK in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (Staphylococcus aureus)	BDBM50181901 (CHEMBL3819615) Show SMILES CNC(=O)CSc1nc2c(nc(N)[nH]c2=O)[nH]1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Staphylococcus aureus HPPK in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50182023 (CHEMBL3818783) Show SMILES Cc1cccc(CSc2nc3c(nc(N)[nH]c3=O)[nH]2)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (Staphylococcus aureus)	BDBM50181516 (CHEMBL3819390) Show SMILES Nc1nc2[nH]c(SCCCO)nc2c(=O)[nH]1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Staphylococcus aureus HPPK in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (Staphylococcus aureus)	BDBM50181517 (CHEMBL3818353) Show SMILES Nc1nc2[nH]c(SCCO)nc2c(=O)[nH]1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Staphylococcus aureus HPPK in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Bos taurus (bovine))	BDBM50200094 (2-amino-1,9-dihydro-6H-purin-6-one \| CHEMBL219568 ...) Show SMILES Nc1nc2nc[nH]c2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by fluorimetric titration analysis				Bioorg Med Chem 20: 6758-69 (2012) Article DOI: 10.1016/j.bmc.2012.08.045 BindingDB Entry DOI: 10.7270/Q23N24H7
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair
Purine nucleoside phosphorylase (Bos taurus (bovine))	BDBM50200094 (2-amino-1,9-dihydro-6H-purin-6-one \| CHEMBL219568 ...) Show SMILES Nc1nc2nc[nH]c2c(=O)[nH]1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a
University of Warsaw Curated by ChEMBL					Assay Description Binding affinity to calf recombinant PNP expressed in Escherichia coli BL21 (DE3) by isothermal titration calorimetry				Bioorg Med Chem 20: 6758-69 (2012) Article DOI: 10.1016/j.bmc.2012.08.045 BindingDB Entry DOI: 10.7270/Q23N24H7
University of Warsaw Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50181863 (CHEMBL3818011) Show SMILES Cc1ccccc1CSc1nc2c(nc(N)[nH]c2=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50497028 (CHEMBL3233217) Show SMILES NC1Nc2ncc(CO)nc2C(O)=N1 \|c:13\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.05E+3	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Binding affinity to GST-tagged Escherichia coli HPPK expressed in Escherichia coli by SPR kinetic method in presence of AMP-CPP				Bioorg Med Chem 22: 2157-65 (2014) Article DOI: 10.1016/j.bmc.2014.02.022 BindingDB Entry DOI: 10.7270/Q2ST7SSH
St. Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50200094 (2-amino-1,9-dihydro-6H-purin-6-one \| CHEMBL219568 ...) Show SMILES Nc1nc2nc[nH]c2c(=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	3.80E+4	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Binding affinity to GST-tagged Escherichia coli HPPK expressed in Escherichia coli by SPR assay based alternative equilibrium affinity method in pres...				Bioorg Med Chem 22: 2157-65 (2014) Article DOI: 10.1016/j.bmc.2014.02.022 BindingDB Entry DOI: 10.7270/Q2ST7SSH
St. Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50200099 (2-Amino-1,7-dihydro-purine-6-thione \| 2-Amino-1,9-...) Show SMILES Nc1nc2nc[nH]c2c(=S)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Binding affinity to GST-tagged Escherichia coli HPPK expressed in Escherichia coli by SPR assay based alternative equilibrium affinity method in pres...				Bioorg Med Chem 22: 2157-65 (2014) Article DOI: 10.1016/j.bmc.2014.02.022 BindingDB Entry DOI: 10.7270/Q2ST7SSH
St. Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50497031 (CHEBI:62462 \| Isoguanine) Show SMILES Nc1nc(=O)[nH]c2nc[nH]c12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Binding affinity to GST-tagged Escherichia coli HPPK expressed in Escherichia coli by SPR assay based alternative equilibrium affinity method in pres...				Bioorg Med Chem 22: 2157-65 (2014) Article DOI: 10.1016/j.bmc.2014.02.022 BindingDB Entry DOI: 10.7270/Q2ST7SSH
St. Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50181897 (CHEMBL178006) Show SMILES Nc1nc2[nH]c(S)nc2c(=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Binding affinity to GST-tagged Escherichia coli HPPK expressed in Escherichia coli by SPR assay based alternative equilibrium affinity method in pres...				Bioorg Med Chem 22: 2157-65 (2014) Article DOI: 10.1016/j.bmc.2014.02.022 BindingDB Entry DOI: 10.7270/Q2ST7SSH
St. Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50497027 (CHEMBL3233216) Show SMILES Cc1nc2c(nc(N)[nH]c2=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Binding affinity to GST-tagged Escherichia coli HPPK expressed in Escherichia coli by SPR assay based alternative equilibrium affinity method in pres...				Bioorg Med Chem 22: 2157-65 (2014) Article DOI: 10.1016/j.bmc.2014.02.022 BindingDB Entry DOI: 10.7270/Q2ST7SSH
St. Jude Children's Research Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50182027 (CHEMBL3819387) Show SMILES Nc1nc2[nH]c(SCc3cccc(F)c3)nc2c(=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50181517 (CHEMBL3818353) Show SMILES Nc1nc2[nH]c(SCCO)nc2c(=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	8.92E+4	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50181516 (CHEMBL3819390) Show SMILES Nc1nc2[nH]c(SCCCO)nc2c(=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	6.80E+4	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50181515 (CHEMBL3819144) Show SMILES Nc1nc2[nH]c(SCC(O)CO)nc2c(=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	8.20E+4	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50181901 (CHEMBL3819615) Show SMILES CNC(=O)CSc1nc2c(nc(N)[nH]c2=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (Escherichia coli (strain K12))	BDBM50182028 (CHEMBL3818744) Show SMILES COCCSc1nc2c(nc(N)[nH]c2=O)[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	5.20E+4	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Escherichia coli HPPK expressed in Escherichia coli BL21 (DE3) in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase (Staphylococcus aureus)	BDBM50182023 (CHEMBL3818783) Show SMILES Cc1cccc(CSc2nc3c(nc(N)[nH]c3=O)[nH]2)c1 Show InChI	PDB KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a
Monash University Curated by ChEMBL					Assay Description Binding affinity to biotinylated Staphylococcus aureus HPPK in presence of 1 mM ATP by SPR assay				J Med Chem 59: 5248-63 (2016) Article DOI: 10.1021/acs.jmedchem.6b00002 BindingDB Entry DOI: 10.7270/Q2057HWV
Monash University Curated by ChEMBL					More data for this Ligand-Target Pair