Found 162 hits with Last Name = 'degterev' and Initial = 'a' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM50564984
(CHEMBL4781373)Show SMILES CCCS(=O)(=O)Nc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK293 cells coexpressing NFkappaB-SEAP reporter measured after 7 to 9 hrs by HEKBIue reporter assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM50568933
(CHEMBL4847211)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CC(C)C)c3n2)cc1 |(1.53,-6.82,;2.86,-6.05,;4.2,-6.82,;4.2,-8.36,;2.86,-9.13,;5.53,-6.05,;6.87,-6.82,;8.2,-6.05,;9.53,-6.82,;9.53,-8.37,;10.86,-9.14,;12.2,-8.36,;13.54,-9.13,;14.87,-8.36,;14.86,-6.82,;16.18,-6.05,;17.53,-6.82,;18.86,-6.04,;20.2,-6.83,;21.53,-6.06,;21.54,-4.53,;20.2,-3.76,;22.87,-3.76,;24.21,-4.54,;24.2,-6.08,;22.86,-6.84,;22.85,-8.38,;20.19,-8.37,;21.52,-9.15,;18.85,-9.13,;18.84,-10.67,;17.5,-11.44,;16.17,-10.66,;17.5,-12.98,;17.52,-8.36,;16.2,-9.13,;12.2,-6.81,;10.86,-6.05,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM50568927
(CHEMBL4853179)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM4077
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CC)c3n2)cc1 Show InChI InChI=1S/C27H31N5O2/c1-4-31(5-2)16-17-34-23-14-12-22(13-15-23)29-27-28-19-21-18-24(20-10-8-7-9-11-20)26(33)32(6-3)25(21)30-27/h7-15,18-19H,4-6,16-17H2,1-3H3,(H,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ALK2 using casein as substrate incubated for 30 mins in presence of [gamma33P]ATP by radiometric hotspot kinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50564975
(CHEMBL4784430)Show SMILES COc1cc(NS(C)(=O)=O)cc(c1)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by kinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM50568929
(CHEMBL4870434)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(O)cc4)c(=O)n(C)c3n2)cc1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50564978
(CHEMBL4776631)Show SMILES COc1cc(NS(=O)(=O)c2ccccc2)cc(c1)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by kinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM50568934
(CHEMBL4864576)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4cccc(c4)S(C)(=O)=O)c3n2)cc1 |(26.34,-6.01,;27.68,-5.24,;29.01,-6.01,;29.01,-7.55,;27.68,-8.32,;30.34,-5.24,;31.68,-6,;33.01,-5.23,;34.34,-6,;34.34,-7.55,;35.68,-8.32,;37.01,-7.55,;38.35,-8.32,;39.68,-7.54,;39.67,-6.01,;40.99,-5.23,;42.34,-6,;43.67,-5.23,;45.01,-6.01,;46.35,-5.25,;46.35,-3.71,;45.01,-2.94,;47.68,-2.94,;49.02,-3.72,;49.01,-5.26,;47.67,-6.02,;47.66,-7.56,;45,-7.55,;46.33,-8.33,;43.66,-8.32,;43.65,-9.86,;42.32,-10.62,;40.99,-9.84,;39.66,-10.6,;39.65,-12.14,;40.99,-12.92,;42.32,-12.15,;40.98,-14.45,;39.65,-15.22,;42.47,-14.05,;42.07,-15.54,;42.33,-7.54,;41.01,-8.31,;37.01,-6,;35.67,-5.23,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568933
(CHEMBL4847211)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CC(C)C)c3n2)cc1 |(1.53,-6.82,;2.86,-6.05,;4.2,-6.82,;4.2,-8.36,;2.86,-9.13,;5.53,-6.05,;6.87,-6.82,;8.2,-6.05,;9.53,-6.82,;9.53,-8.37,;10.86,-9.14,;12.2,-8.36,;13.54,-9.13,;14.87,-8.36,;14.86,-6.82,;16.18,-6.05,;17.53,-6.82,;18.86,-6.04,;20.2,-6.83,;21.53,-6.06,;21.54,-4.53,;20.2,-3.76,;22.87,-3.76,;24.21,-4.54,;24.2,-6.08,;22.86,-6.84,;22.85,-8.38,;20.19,-8.37,;21.52,-9.15,;18.85,-9.13,;18.84,-10.67,;17.5,-11.44,;16.17,-10.66,;17.5,-12.98,;17.52,-8.36,;16.2,-9.13,;12.2,-6.81,;10.86,-6.05,)| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568936
(CHEMBL4864600)Show SMILES Cn1c2nc(Nc3cccc(c3)S(C)(=O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(31.78,-28.56,;31.78,-27.03,;30.46,-26.25,;29.13,-27.02,;27.81,-26.25,;26.47,-27.02,;25.14,-26.26,;23.8,-27.03,;22.47,-26.26,;22.47,-24.71,;23.8,-23.94,;25.13,-24.71,;23.79,-22.4,;25.13,-21.63,;22.3,-21.99,;23.39,-20.9,;27.79,-24.72,;29.12,-23.94,;30.46,-24.71,;31.8,-23.94,;33.13,-24.72,;34.47,-23.96,;34.47,-22.42,;33.14,-21.65,;35.8,-21.65,;37.14,-22.43,;37.13,-23.97,;35.79,-24.73,;35.78,-26.27,;33.13,-26.26,;34.45,-27.04,)| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568937
(CHEMBL4861488)Show SMILES Cn1c2nc(Nc3cccc(c3)S(C)(=O)=O)ncc2cc(-c2ccccc2Cl)c1=O | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50568932
(CHEMBL4858463)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4ccccc4)c3n2)cc1 |(58.86,-44.1,;60.19,-43.33,;61.53,-44.1,;61.53,-45.64,;60.19,-46.41,;62.86,-43.33,;64.19,-44.1,;65.53,-43.33,;66.86,-44.1,;66.86,-45.64,;68.19,-46.41,;69.53,-45.64,;70.87,-46.41,;72.2,-45.64,;72.19,-44.1,;73.51,-43.33,;74.86,-44.1,;76.19,-43.32,;77.53,-44.1,;78.86,-43.34,;78.86,-41.81,;77.53,-41.04,;80.2,-41.04,;81.54,-41.82,;81.53,-43.36,;80.19,-44.12,;80.18,-45.66,;77.52,-45.65,;78.85,-46.43,;76.18,-46.41,;76.17,-47.95,;74.83,-48.72,;73.51,-47.93,;72.17,-48.69,;72.17,-50.24,;73.51,-51.01,;74.84,-50.25,;74.85,-45.64,;73.53,-46.41,;69.53,-44.09,;68.19,-43.33,)| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ALK2 using casein as substrate incubated for 30 mins in presence of [gamma33P]ATP by radiometric hotspot kinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM50568932
(CHEMBL4858463)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4ccccc4)c3n2)cc1 |(58.86,-44.1,;60.19,-43.33,;61.53,-44.1,;61.53,-45.64,;60.19,-46.41,;62.86,-43.33,;64.19,-44.1,;65.53,-43.33,;66.86,-44.1,;66.86,-45.64,;68.19,-46.41,;69.53,-45.64,;70.87,-46.41,;72.2,-45.64,;72.19,-44.1,;73.51,-43.33,;74.86,-44.1,;76.19,-43.32,;77.53,-44.1,;78.86,-43.34,;78.86,-41.81,;77.53,-41.04,;80.2,-41.04,;81.54,-41.82,;81.53,-43.36,;80.19,-44.12,;80.18,-45.66,;77.52,-45.65,;78.85,-46.43,;76.18,-46.41,;76.17,-47.95,;74.83,-48.72,;73.51,-47.93,;72.17,-48.69,;72.17,-50.24,;73.51,-51.01,;74.84,-50.25,;74.85,-45.64,;73.53,-46.41,;69.53,-44.09,;68.19,-43.33,)| | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50564976
(CHEMBL4800115)Show SMILES CCCS(=O)(=O)Nc1cc(OC)cc(c1)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by kinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50568933
(CHEMBL4847211)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CC(C)C)c3n2)cc1 |(1.53,-6.82,;2.86,-6.05,;4.2,-6.82,;4.2,-8.36,;2.86,-9.13,;5.53,-6.05,;6.87,-6.82,;8.2,-6.05,;9.53,-6.82,;9.53,-8.37,;10.86,-9.14,;12.2,-8.36,;13.54,-9.13,;14.87,-8.36,;14.86,-6.82,;16.18,-6.05,;17.53,-6.82,;18.86,-6.04,;20.2,-6.83,;21.53,-6.06,;21.54,-4.53,;20.2,-3.76,;22.87,-3.76,;24.21,-4.54,;24.2,-6.08,;22.86,-6.84,;22.85,-8.38,;20.19,-8.37,;21.52,-9.15,;18.85,-9.13,;18.84,-10.67,;17.5,-11.44,;16.17,-10.66,;17.5,-12.98,;17.52,-8.36,;16.2,-9.13,;12.2,-6.81,;10.86,-6.05,)| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ALK2 using casein as substrate incubated for 30 mins in presence of [gamma33P]ATP by radiometric hotspot kinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50564977
(CHEMBL4781705)Show SMILES COc1cc(NS(=O)(=O)C(C)C)cc(c1)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by kinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50564997
(CHEMBL4799077)Show SMILES CCCS(=O)(=O)Nc1cc(cc(F)c1OC)-c1cc(cnc1N)-c1cccc(c1)N1CCNCC1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human RIPK2 incubated for 2 hr by ADP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568950
(CHEMBL4861447)Show SMILES COc1ccc(cc1)-c1cc2cnc(Nc3cccc(c3)S(C)(=O)=O)nc2n(C)c1=O | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM4067
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-meth...)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(C)c3n2)cc1 Show InChI InChI=1S/C26H29N5O2/c1-4-31(5-2)15-16-33-22-13-11-21(12-14-22)28-26-27-18-20-17-23(19-9-7-6-8-10-19)25(32)30(3)24(20)29-26/h6-14,17-18H,4-5,15-16H2,1-3H3,(H,27,28,29) | PDB
UniProtKB/SwissProt
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Similars
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| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM3096
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)| Show InChI InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31) | PDB
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM50568931
(CHEMBL4859716)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CCOC)c3n2)cc1 |(30.47,-43.28,;31.8,-42.51,;33.14,-43.28,;33.14,-44.82,;31.81,-45.59,;34.47,-42.51,;35.81,-43.28,;37.14,-42.51,;38.47,-43.28,;38.47,-44.83,;39.81,-45.6,;41.14,-44.83,;42.48,-45.59,;43.81,-44.82,;43.8,-43.29,;45.12,-42.51,;46.47,-43.28,;47.8,-42.51,;49.14,-43.29,;50.47,-42.52,;51.8,-43.3,;51.79,-44.84,;53.14,-42.54,;53.15,-41,;51.81,-40.22,;50.48,-40.99,;49.14,-40.22,;49.13,-44.83,;50.46,-45.61,;47.79,-45.6,;47.78,-47.14,;46.44,-47.9,;46.44,-49.44,;45.1,-50.2,;46.46,-44.82,;45.14,-45.59,;41.14,-43.28,;39.8,-42.51,)| | PDB
Reactome pathway
KEGG
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antibodypedia
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| Article
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568928
(CHEMBL4852860)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(Cl)cc4)c(=O)n(C)c3n2)cc1 | PDB
UniProtKB/SwissProt
antibodypedia
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50564977
(CHEMBL4781705)Show SMILES COc1cc(NS(=O)(=O)C(C)C)cc(c1)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
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antibodypedia
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human RIPK2 incubated for 2 hr by ADP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568935
(CHEMBL4868894)Show SMILES Cn1c2nc(Nc3ccc(cc3)S(C)(=O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(13.36,-27.74,;13.37,-26.2,;12.04,-25.43,;10.72,-26.2,;9.39,-25.43,;8.06,-26.2,;6.72,-25.43,;5.39,-26.2,;4.05,-25.43,;4.06,-23.89,;5.38,-23.12,;6.72,-23.88,;2.72,-23.12,;1.39,-23.89,;1.94,-21.78,;3.49,-21.78,;9.38,-23.89,;10.7,-23.12,;12.05,-23.89,;13.38,-23.11,;14.72,-23.9,;16.05,-23.13,;16.05,-21.6,;14.72,-20.83,;17.38,-20.83,;18.72,-21.61,;18.71,-23.15,;17.38,-23.91,;17.37,-25.45,;14.71,-25.44,;16.04,-26.22,)| | PDB
UniProtKB/SwissProt
antibodypedia
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| PC cid
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| Article
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50564976
(CHEMBL4800115)Show SMILES CCCS(=O)(=O)Nc1cc(OC)cc(c1)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human RIPK2 incubated for 2 hr by ADP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM4067
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-meth...)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(C)c3n2)cc1 Show InChI InChI=1S/C26H29N5O2/c1-4-31(5-2)15-16-33-22-13-11-21(12-14-22)28-26-27-18-20-17-23(19-9-7-6-8-10-19)25(32)30(3)24(20)29-26/h6-14,17-18H,4-5,15-16H2,1-3H3,(H,27,28,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
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AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568949
(CHEMBL4875011)Show SMILES Cc1ccc(c(Cl)c1)-c1cc2cnc(Nc3cccc(c3)S(C)(=O)=O)nc2n(C)c1=O | PDB
UniProtKB/SwissProt
antibodypedia
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM4077
(2-({4-[2-(diethylamino)ethoxy]phenyl}amino)-8-ethy...)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CC)c3n2)cc1 Show InChI InChI=1S/C27H31N5O2/c1-4-31(5-2)16-17-34-23-14-12-22(13-15-23)29-27-28-19-21-18-24(20-10-8-7-9-11-20)26(33)32(6-3)25(21)30-27/h7-15,18-19H,4-6,16-17H2,1-3H3,(H,28,29,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568943
(CHEMBL4864714)Show SMILES Cn1c2nc(Nc3cccc(c3)S(C)(=O)=O)ncc2cc(-c2ccc(Cl)cc2)c1=O | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50564987
(CHEMBL4789724)Show SMILES CCCS(=O)(=O)Nc1cc(cc(F)c1OC)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human RIPK2 incubated for 2 hr by ADP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM50564997
(CHEMBL4799077)Show SMILES CCCS(=O)(=O)Nc1cc(cc(F)c1OC)-c1cc(cnc1N)-c1cccc(c1)N1CCNCC1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK293 cells coexpressing NFkappaB-SEAP reporter measured after 7 to 9 hrs by HEKBIue reporter assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568939
(CHEMBL4849134)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(Cl)cc4Cl)c(=O)n(C)c3n2)cc1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
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PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568938
(CHEMBL4867467)Show SMILES Cn1c2nc(Nc3cccc(c3)S(C)(=O)=O)ncc2cc(-c2ccc(O)cc2)c1=O | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568947
(CHEMBL4867716)Show SMILES Cn1c2nc(Nc3cccc(c3)S(C)(=O)=O)ncc2cc(-c2ccc(F)cc2Cl)c1=O | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568927
(CHEMBL4853179)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4Cl)c(=O)n(C)c3n2)cc1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50568931
(CHEMBL4859716)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(CCOC)c3n2)cc1 |(30.47,-43.28,;31.8,-42.51,;33.14,-43.28,;33.14,-44.82,;31.81,-45.59,;34.47,-42.51,;35.81,-43.28,;37.14,-42.51,;38.47,-43.28,;38.47,-44.83,;39.81,-45.6,;41.14,-44.83,;42.48,-45.59,;43.81,-44.82,;43.8,-43.29,;45.12,-42.51,;46.47,-43.28,;47.8,-42.51,;49.14,-43.29,;50.47,-42.52,;51.8,-43.3,;51.79,-44.84,;53.14,-42.54,;53.15,-41,;51.81,-40.22,;50.48,-40.99,;49.14,-40.22,;49.13,-44.83,;50.46,-45.61,;47.79,-45.6,;47.78,-47.14,;46.44,-47.9,;46.44,-49.44,;45.1,-50.2,;46.46,-44.82,;45.14,-45.59,;41.14,-43.28,;39.8,-42.51,)| | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ALK2 using casein as substrate incubated for 30 mins in presence of [gamma33P]ATP by radiometric hotspot kinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50568930
(CHEMBL4871544)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccccc4)c(=O)n(CCO)c3n2)cc1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ALK2 using casein as substrate incubated for 30 mins in presence of [gamma33P]ATP by radiometric hotspot kinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50564980
(CHEMBL4792496)Show SMILES CC(C)Oc1cc(NS(=O)(=O)C(C)C)cc(c1)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human RIPK2 incubated for 2 hr by ADP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM50568937
(CHEMBL4861488)Show SMILES Cn1c2nc(Nc3cccc(c3)S(C)(=O)=O)ncc2cc(-c2ccccc2Cl)c1=O | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50564984
(CHEMBL4781373)Show SMILES CCCS(=O)(=O)Nc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human RIPK2 incubated for 2 hr by ADP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50564979
(CHEMBL4795976)Show SMILES CCOc1cc(NS(=O)(=O)C(C)C)cc(c1)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
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| Article
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human RIPK2 incubated for 2 hr by ADP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568942
(CHEMBL4874031)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4ccc(cc4)S(C)(=O)=O)c3n2)cc1 |(54.68,-6.89,;56.02,-6.11,;57.35,-6.88,;57.35,-8.42,;56.02,-9.19,;58.68,-6.11,;60.02,-6.88,;61.35,-6.11,;62.69,-6.88,;62.68,-8.43,;64.02,-9.2,;65.36,-8.43,;66.69,-9.19,;68.02,-8.42,;68.01,-6.89,;69.34,-6.11,;70.68,-6.88,;72.01,-6.11,;73.35,-6.89,;74.69,-6.12,;74.69,-4.59,;73.36,-3.82,;76.02,-3.82,;77.36,-4.6,;77.35,-6.14,;76.01,-6.9,;76.01,-8.44,;73.34,-8.43,;74.67,-9.21,;72,-9.2,;72,-10.74,;70.66,-11.5,;69.33,-10.72,;68,-11.48,;67.99,-13.02,;69.33,-13.8,;70.66,-13.03,;66.65,-13.78,;65.32,-13.01,;67.41,-15.11,;65.88,-15.11,;70.68,-8.42,;69.35,-9.19,;65.35,-6.88,;64.01,-6.11,)| | PDB
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568941
(CHEMBL4852513)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4ccc(OC)cc4)c(=O)n(C)c3n2)cc1 | PDB
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568932
(CHEMBL4858463)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(Cc4ccccc4)c3n2)cc1 |(58.86,-44.1,;60.19,-43.33,;61.53,-44.1,;61.53,-45.64,;60.19,-46.41,;62.86,-43.33,;64.19,-44.1,;65.53,-43.33,;66.86,-44.1,;66.86,-45.64,;68.19,-46.41,;69.53,-45.64,;70.87,-46.41,;72.2,-45.64,;72.19,-44.1,;73.51,-43.33,;74.86,-44.1,;76.19,-43.32,;77.53,-44.1,;78.86,-43.34,;78.86,-41.81,;77.53,-41.04,;80.2,-41.04,;81.54,-41.82,;81.53,-43.36,;80.19,-44.12,;80.18,-45.66,;77.52,-45.65,;78.85,-46.43,;76.18,-46.41,;76.17,-47.95,;74.83,-48.72,;73.51,-47.93,;72.17,-48.69,;72.17,-50.24,;73.51,-51.01,;74.84,-50.25,;74.85,-45.64,;73.53,-46.41,;69.53,-44.09,;68.19,-43.33,)| | PDB
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TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM3096
(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)Show SMILES CCN(CC)CCOc1ccc(Nc2ncc3cc(-c4c(Cl)cccc4Cl)c(=O)n(C)c3n2)cc1 |(-8.3,-10.68,;-6.82,-11.08,;-5.73,-9.99,;-4.24,-10.39,;-3.15,-9.3,;-6.82,-8.9,;-6.82,-7.36,;-8.15,-6.59,;-8.15,-5.05,;-6.82,-4.28,;-6.82,-2.74,;-8.15,-1.97,;-8.15,-.43,;-6.82,.34,;-6.82,1.88,;-5.48,2.65,;-4.15,1.88,;-2.82,2.65,;-1.48,1.88,;-.15,2.65,;-.15,4.19,;-1.48,4.96,;1.18,4.96,;2.52,4.19,;2.52,2.65,;1.18,1.88,;1.18,.34,;-1.48,.34,;-.15,-.43,;-2.82,-.43,;-2.82,-1.97,;-4.15,.34,;-5.48,-.43,;-9.48,-2.74,;-9.48,-4.28,)| Show InChI InChI=1S/C26H27Cl2N5O2/c1-4-33(5-2)13-14-35-19-11-9-18(10-12-19)30-26-29-16-17-15-20(25(34)32(3)24(17)31-26)23-21(27)7-6-8-22(23)28/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,30,31) | PDB
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| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ALK2 using casein as substrate incubated for 30 mins in presence of [gamma33P]ATP by radiometric hotspot kinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50564988
(CHEMBL4793153)Show SMILES CCCS(=O)(=O)Nc1cc(cc(Cl)c1OC)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human RIPK2 incubated for 2 hr by ADP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50568948
(CHEMBL4853711)Show SMILES Cn1c2nc(Nc3cccc(c3)S(C)(=O)=O)ncc2cc(-c2cc(Cl)ccc2Cl)c1=O | PDB
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| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant RIPK2 (unknown origin) using RS repeat peptide as substrate preincubated for 5 mins followed by substrate and ATP addition ... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Nucleotide-binding oligomerization domain-containing protein 2
(Homo sapiens (Human)) | BDBM50568936
(CHEMBL4864600)Show SMILES Cn1c2nc(Nc3cccc(c3)S(C)(=O)=O)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(31.78,-28.56,;31.78,-27.03,;30.46,-26.25,;29.13,-27.02,;27.81,-26.25,;26.47,-27.02,;25.14,-26.26,;23.8,-27.03,;22.47,-26.26,;22.47,-24.71,;23.8,-23.94,;25.13,-24.71,;23.79,-22.4,;25.13,-21.63,;22.3,-21.99,;23.39,-20.9,;27.79,-24.72,;29.12,-23.94,;30.46,-24.71,;31.8,-23.94,;33.13,-24.72,;34.47,-23.96,;34.47,-22.42,;33.14,-21.65,;35.8,-21.65,;37.14,-22.43,;37.13,-23.97,;35.79,-24.73,;35.78,-26.27,;33.13,-26.26,;34.45,-27.04,)| | PDB
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TBA
| Assay Description
Inhibition of human NOD2 expressed in HEK-blue cells coexpressing NFkappaB-SEAP reporter assessed as reduction in L18-MDP-induced NF-kappaB activatio... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113252
BindingDB Entry DOI: 10.7270/Q21Z4863 |
More data for this
Ligand-Target Pair | |
Receptor-interacting serine/threonine-protein kinase 2
(Homo sapiens (Human)) | BDBM50564978
(CHEMBL4776631)Show SMILES COc1cc(NS(=O)(=O)c2ccccc2)cc(c1)-c1cc(cnc1N)-c1ccc(cc1)N1CCNCC1 | PDB
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| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human RIPK2 incubated for 2 hr by ADP-Glo assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
Activin receptor type-1
(Homo sapiens (Human)) | BDBM50056676
(CHEMBL3341789)Show SMILES COc1cc(cc(OC)c1OC)-c1cc(cnc1C)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C25H29N3O3/c1-17-22(19-14-23(29-2)25(31-4)24(15-19)30-3)13-20(16-27-17)18-5-7-21(8-6-18)28-11-9-26-10-12-28/h5-8,13-16,26H,9-12H2,1-4H3 | PDB
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| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by kinase assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112417
BindingDB Entry DOI: 10.7270/Q2M0495P |
More data for this
Ligand-Target Pair | |
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