Found 35 hits with Last Name = 'nevarez' and Initial = 'a' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50540861
![PNG](/data/jpeg/tenK5054/BindingDB_50540861.png) (EFT-226 | Eft226 | Zotatifin)Show SMILES COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N Show InChI InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50576672
![PNG](/data/jpeg/tenK5057/BindingDB_50576672.png) (CHEMBL4857096)Show SMILES COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CNC4COC4)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-Myc |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128111 BindingDB Entry DOI: 10.7270/Q2GQ72K9 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50196926
![PNG](/data/jpeg/tenK5019/BindingDB_50196926.png) (CHEMBL438139 | Rocaglamide | US10085988, Compound ...)Show SMILES COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C |r| Show InChI InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50576670
![PNG](/data/jpeg/tenK5057/BindingDB_50576670.png) (CHEMBL4864162)Show SMILES COc1cncc2O[C@]3([C@@H](C[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-Myc |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128111 BindingDB Entry DOI: 10.7270/Q2GQ72K9 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50576669
![PNG](/data/jpeg/tenK5057/BindingDB_50576669.png) (CHEMBL4855528)Show SMILES COc1cncc2O[C@]3([C@@H](C[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(cc1)C#N |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-Myc |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128111 BindingDB Entry DOI: 10.7270/Q2GQ72K9 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50540861
![PNG](/data/jpeg/tenK5054/BindingDB_50540861.png) (EFT-226 | Eft226 | Zotatifin)Show SMILES COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N Show InChI InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human HAP1 cells assessed as reduction in cell proliferation incubated for 72 hrs by CellTiter-Glo reagent based assay |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50576673
![PNG](/data/jpeg/tenK5057/BindingDB_50576673.png) (CHEMBL4849769)Show SMILES COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CN4CCOCC4)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-Myc |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128111 BindingDB Entry DOI: 10.7270/Q2GQ72K9 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50576672
![PNG](/data/jpeg/tenK5057/BindingDB_50576672.png) (CHEMBL4857096)Show SMILES COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CNC4COC4)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulin |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128111 BindingDB Entry DOI: 10.7270/Q2GQ72K9 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50540861
![PNG](/data/jpeg/tenK5054/BindingDB_50540861.png) (EFT-226 | Eft226 | Zotatifin)Show SMILES COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N Show InChI InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50576670
![PNG](/data/jpeg/tenK5057/BindingDB_50576670.png) (CHEMBL4864162)Show SMILES COc1cncc2O[C@]3([C@@H](C[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulin |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128111 BindingDB Entry DOI: 10.7270/Q2GQ72K9 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50576669
![PNG](/data/jpeg/tenK5057/BindingDB_50576669.png) (CHEMBL4855528)Show SMILES COc1cncc2O[C@]3([C@@H](C[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(cc1)C#N |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulin |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128111 BindingDB Entry DOI: 10.7270/Q2GQ72K9 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50576671
![PNG](/data/jpeg/tenK5057/BindingDB_50576671.png) (CHEMBL4875109)Show SMILES COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring highly structured 5'-UTR of c-Myc |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128111 BindingDB Entry DOI: 10.7270/Q2GQ72K9 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50576673
![PNG](/data/jpeg/tenK5057/BindingDB_50576673.png) (CHEMBL4849769)Show SMILES COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CN4CCOCC4)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulin |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128111 BindingDB Entry DOI: 10.7270/Q2GQ72K9 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50196926
![PNG](/data/jpeg/tenK5019/BindingDB_50196926.png) (CHEMBL438139 | Rocaglamide | US10085988, Compound ...)Show SMILES COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C |r| Show InChI InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50080528
![PNG](/data/jpeg/tenK5008/BindingDB_50080528.png) (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)Show SMILES C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1 |r| Show InChI InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50576671
![PNG](/data/jpeg/tenK5057/BindingDB_50576671.png) (CHEMBL4875109)Show SMILES COc1cncc2O[C@]3([C@@H]([C@@H](CO)[C@H](CN)[C@@]3(O)c12)c1ccccc1)c1ccc(Br)cc1 |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of eIF4A (unknown origin) assessed as inhibition of translation of RNA featuring short 5'-UTR of tubulin |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128111 BindingDB Entry DOI: 10.7270/Q2GQ72K9 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50540861
![PNG](/data/jpeg/tenK5054/BindingDB_50540861.png) (EFT-226 | Eft226 | Zotatifin)Show SMILES COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N Show InChI InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 92 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50080528
![PNG](/data/jpeg/tenK5008/BindingDB_50080528.png) (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)Show SMILES C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1 |r| Show InChI InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 101 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50196926
![PNG](/data/jpeg/tenK5019/BindingDB_50196926.png) (CHEMBL438139 | Rocaglamide | US10085988, Compound ...)Show SMILES COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C |r| Show InChI InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 135 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50080528
![PNG](/data/jpeg/tenK5008/BindingDB_50080528.png) (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)Show SMILES C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1 |r| Show InChI InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL KEGG PC cid PC sid PDB UniChem
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| Article PubMed
| n/a | n/a | 142 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50235738
![PNG](/data/jpeg/tenK5023/BindingDB_50235738.png) (Hippuristanol)Show SMILES [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 204 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50235738
![PNG](/data/jpeg/tenK5023/BindingDB_50235738.png) (Hippuristanol)Show SMILES [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50540861
![PNG](/data/jpeg/tenK5054/BindingDB_50540861.png) (EFT-226 | Eft226 | Zotatifin)Show SMILES COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N Show InChI InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 218 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50080528
![PNG](/data/jpeg/tenK5008/BindingDB_50080528.png) (3-((R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)...)Show SMILES C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC1CC(=O)NC(=O)C1 |r| Show InChI InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL KEGG PC cid PC sid PDB UniChem
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Similars
| Article PubMed
| n/a | n/a | 226 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50196926
![PNG](/data/jpeg/tenK5019/BindingDB_50196926.png) (CHEMBL438139 | Rocaglamide | US10085988, Compound ...)Show SMILES COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C |r| Show InChI InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL MCE PC cid PC sid PDB UniChem
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| PDB Article PubMed
| n/a | n/a | 231 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50235738
![PNG](/data/jpeg/tenK5023/BindingDB_50235738.png) (Hippuristanol)Show SMILES [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 369 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50235738
![PNG](/data/jpeg/tenK5023/BindingDB_50235738.png) (Hippuristanol)Show SMILES [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 426 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50540859
![PNG](/data/jpeg/tenK5054/BindingDB_50540859.png) (CHEMBL4632904)Show SMILES COc1cncc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c12)c1ccccc1)c1ccc(cc1)C#N |r| Show InChI InChI=1S/C27H27N3O4/c1-30(2)16-20-23(18-7-5-4-6-8-18)27(19-11-9-17(13-28)10-12-19)26(32,25(20)31)24-21(33-3)14-29-15-22(24)34-27/h4-12,14-15,20,23,25,31-32H,16H2,1-3H3/t20-,23-,25-,26+,27+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of human ERG by patch-clamp assay |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50540860
![PNG](/data/jpeg/tenK5054/BindingDB_50540860.png) (CHEMBL4645423)Show SMILES COc1nc(cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c12)c1ccccc1)c1ccc(cc1)C#N)C#N |r| Show InChI InChI=1S/C28H26N4O4/c1-32(2)16-21-23(18-7-5-4-6-8-18)28(19-11-9-17(14-29)10-12-19)27(34,25(21)33)24-22(36-28)13-20(15-30)31-26(24)35-3/h4-13,21,23,25,33-34H,16H2,1-3H3/t21-,23-,25-,27+,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of human ERG by patch-clamp assay |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50540861
![PNG](/data/jpeg/tenK5054/BindingDB_50540861.png) (EFT-226 | Eft226 | Zotatifin)Show SMILES COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N Show InChI InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Inhibition of human ERG by patch-clamp assay |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50196926
![PNG](/data/jpeg/tenK5019/BindingDB_50196926.png) (CHEMBL438139 | Rocaglamide | US10085988, Compound ...)Show SMILES COc1ccc(cc1)[C@@]12Oc3cc(OC)cc(OC)c3[C@]1(O)[C@H](O)[C@@H]([C@H]2c1ccccc1)C(=O)N(C)C |r| Show InChI InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 156 | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50540861
![PNG](/data/jpeg/tenK5054/BindingDB_50540861.png) (EFT-226 | Eft226 | Zotatifin)Show SMILES COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N Show InChI InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 3.19E+3 | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50540861
![PNG](/data/jpeg/tenK5054/BindingDB_50540861.png) (EFT-226 | Eft226 | Zotatifin)Show SMILES COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N Show InChI InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 9.60E+3 | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50540861
![PNG](/data/jpeg/tenK5054/BindingDB_50540861.png) (EFT-226 | Eft226 | Zotatifin)Show SMILES COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N Show InChI InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 2.43E+3 | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |
Eukaryotic initiation factor 4A-I
(Homo sapiens (Human)) | BDBM50540861
![PNG](/data/jpeg/tenK5054/BindingDB_50540861.png) (EFT-226 | Eft226 | Zotatifin)Show SMILES COc1cc2O[C@]3([C@@H]([C@@H](CN(C)C)[C@@H](O)[C@@]3(O)c2c(OC)n1)c1ccccc1)c1ccc(cc1)C#N Show InChI InChI=1S/C28H29N3O5/c1-31(2)16-20-23(18-8-6-5-7-9-18)28(19-12-10-17(15-29)11-13-19)27(33,25(20)32)24-21(36-28)14-22(34-3)30-26(24)35-4/h5-14,20,23,25,32-33H,16H2,1-4H3/t20-,23-,25-,27+,28+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a |
Inception Therapeutics
Curated by ChEMBL
| Assay Description Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin... |
J Med Chem 63: 5879-5955 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00182 BindingDB Entry DOI: 10.7270/Q2MC93K8 |
More data for this Ligand-Target Pair | |