Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50493818 (Oliceridine | TRV-130 | US11124523, Comparative Co...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | PDB Article PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Trevena, Inc. Curated by ChEMBL | Assay Description Binding affinity to human mu opioid receptor by radio-ligand binding assay | J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50002595 (Solabegron) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Displacement of [125I]cyanopindolol from human cloned beta-1 adrenergic receptor expressed in Sf9 cells | J Med Chem 49: 2758-71 (2006) Checked by Author Article DOI: 10.1021/jm0509445 BindingDB Entry DOI: 10.7270/Q2KD20D5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50002595 (Solabegron) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Displacement of [125I]cyanopindolol from human cloned beta-2 adrenergic receptor expressed in Sf9 cells | J Med Chem 49: 2758-71 (2006) Checked by Author Article DOI: 10.1021/jm0509445 BindingDB Entry DOI: 10.7270/Q2KD20D5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546132 (CHEMBL4759048) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of SPPL2a in human U2OS cells cotransfected with EGFP-labeled TNFalpha (1 to 76 residues)-NTF incubated for 24 hrs by Hoechst staining bas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT) | BDBM82258 (CAS_114798-26-4 | Losartan | NSC_3961) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats | J Med Chem 38: 4670-8 (1995) Article DOI: 10.1021/jm00023a006 BindingDB Entry DOI: 10.7270/Q21J9DHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Mus musculus) | BDBM50546132 (CHEMBL4759048) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of mouse SPPL2a cotransfected with EGFP-NLP-fused TNFalpha (1 to 77 residues)-NTF incubated for 24 hrs by Hoechst staining based Cellomics... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546130 (CHEMBL4762492) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546132 (CHEMBL4759048) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546128 (CHEMBL4753654) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546125 (CHEMBL4792187) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT) | BDBM50470654 (CHEMBL141019) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats | J Med Chem 38: 4670-8 (1995) Article DOI: 10.1021/jm00023a006 BindingDB Entry DOI: 10.7270/Q21J9DHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546131 (CHEMBL4759943) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT) | BDBM50003392 (2-Methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats | J Med Chem 38: 4670-8 (1995) Article DOI: 10.1021/jm00023a006 BindingDB Entry DOI: 10.7270/Q21J9DHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546124 (CHEMBL4740837) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT) | BDBM50029659 (2-Methyl-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylsul...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 96 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats | J Med Chem 38: 4670-8 (1995) Article DOI: 10.1021/jm00023a006 BindingDB Entry DOI: 10.7270/Q21J9DHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Mus musculus) | BDBM50546132 (CHEMBL4759048) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of SPPL2a in Balb/c mouse A20 cells assessed as reduction in CD74/p8 NTF accumulation incubated for overnight by Western blot analysis | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546118 (CHEMBL4762370) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT) | BDBM50003391 (2-Methyl-4-{2-[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats | J Med Chem 38: 4670-8 (1995) Article DOI: 10.1021/jm00023a006 BindingDB Entry DOI: 10.7270/Q21J9DHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2B (Homo sapiens) | BDBM50546132 (CHEMBL4759048) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of SPPL2b in human U2OS cells cotransfected with EGFP-labeled TNFalpha (1 to 76 residues)-NTF incubated for 24 hrs by Hoechst staining bas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT) | BDBM50470658 (CHEMBL142409) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats | J Med Chem 38: 4670-8 (1995) Article DOI: 10.1021/jm00023a006 BindingDB Entry DOI: 10.7270/Q21J9DHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546122 (CHEMBL4747630) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT) | BDBM50003406 (2-Methyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmet...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats | J Med Chem 38: 4670-8 (1995) Article DOI: 10.1021/jm00023a006 BindingDB Entry DOI: 10.7270/Q21J9DHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546123 (CHEMBL4789381) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50422411 (CHEMBL154419) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 794 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Receptor binding assay(Beta-2 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r... | J Med Chem 45: 567-83 (2002) BindingDB Entry DOI: 10.7270/Q2W0976P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546129 (CHEMBL4785324) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 840 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546120 (CHEMBL4743609) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546127 (CHEMBL4753079) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546121 (CHEMBL4798232) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50422411 (CHEMBL154419) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Receptor binding assay(Beta-1 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r... | J Med Chem 45: 567-83 (2002) BindingDB Entry DOI: 10.7270/Q2W0976P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50546132 (CHEMBL4759048) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT) | BDBM50470655 (CHEMBL341724) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats | J Med Chem 38: 4670-8 (1995) Article DOI: 10.1021/jm00023a006 BindingDB Entry DOI: 10.7270/Q21J9DHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546126 (CHEMBL4741014) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50546128 (CHEMBL4753654) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50422410 (CHEMBL348501) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Receptor binding assay(Beta-1 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r... | J Med Chem 45: 567-83 (2002) BindingDB Entry DOI: 10.7270/Q2W0976P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50546125 (CHEMBL4792187) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50493811 (CHEMBL2443278) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trevena, Inc. Curated by ChEMBL | Assay Description Inhibition of human ERG channel expressed in HEK293 cells by whole-cell patch clamp technique | J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50546123 (CHEMBL4789381) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50546130 (CHEMBL4762492) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50546131 (CHEMBL4759943) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal peptide peptidase-like 2A (Homo sapiens) | BDBM50546119 (CHEMBL4762488) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50493818 (Oliceridine | TRV-130 | US11124523, Comparative Co...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trevena, Inc. Curated by ChEMBL | Assay Description Inhibition of human Nav 1.5 phasic ion channel expressed in HEK293 cells by whole-cell patch clamp technique | J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor A/Type-1 angiotensin II receptor B/Type-2 angiotensin II receptor (RAT) | BDBM50470656 (CHEMBL358791) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Burroughs Wellcome Co. Curated by ChEMBL | Assay Description Displacement of [3H]-AII from the Angiotensin II receptor isolated from the liver of rats | J Med Chem 38: 4670-8 (1995) Article DOI: 10.1021/jm00023a006 BindingDB Entry DOI: 10.7270/Q21J9DHJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2 (Homo sapiens (Human)) | BDBM50546118 (CHEMBL4762370) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-2 adrenergic receptor (Homo sapiens (Human)) | BDBM50422410 (CHEMBL348501) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Receptor binding assay(Beta-2 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r... | J Med Chem 45: 567-83 (2002) BindingDB Entry DOI: 10.7270/Q2W0976P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Beta-1 adrenergic receptor (Homo sapiens (Human)) | BDBM50422409 (CHEMBL347582) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Receptor binding assay(Beta-1 adrenergic receptor) carried out with membranes prepared from human recombinant Sf9 cells expressing the cloned human r... | J Med Chem 45: 567-83 (2002) BindingDB Entry DOI: 10.7270/Q2W0976P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50546124 (CHEMBL4740837) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50546122 (CHEMBL4747630) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50493818 (Oliceridine | TRV-130 | US11124523, Comparative Co...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trevena, Inc. Curated by ChEMBL | Assay Description Inhibition of human ERG channel expressed in HEK293 cells by whole-cell patch clamp technique | J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-1 (Homo sapiens (Human)) | BDBM50546127 (CHEMBL4753079) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas... | Citation and Details Article DOI: 10.1021/acsmedchemlett.9b00044 BindingDB Entry DOI: 10.7270/Q2S1863Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human)) | BDBM50493811 (CHEMBL2443278) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trevena, Inc. Curated by ChEMBL | Assay Description Inhibition of human Nav 1.5 phasic ion channel expressed in HEK293 cells by whole-cell patch clamp technique | J Med Chem 56: 8019-31 (2013) Article DOI: 10.1021/jm4010829 BindingDB Entry DOI: 10.7270/Q2FT8Q0N | |||||||||||
More data for this Ligand-Target Pair |
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