BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 257 hits with Last Name = 'cho' and Initial = 'eh'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480612
PNG
(CHEMBL550916)
Show SMILES CC(C)c1c(Sc2cc(C)cc(C)c2)n(CC2CC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C19H24N2O2S/c1-11(2)16-17(22)20-19(23)21(10-14-5-6-14)18(16)24-15-8-12(3)7-13(4)9-15/h7-9,11,14H,5-6,10H2,1-4H3,(H,20,22,23)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473585
PNG
(US10844062, Example 21)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)36-21-12-18(8-9-20(21)28)35-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,35)(H,36,37)(H,31,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 4.10n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480595
PNG
(CHEMBL560576)
Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CC2CCCCC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C23H30N2O3/c1-14(2)19-20(21(26)18-11-15(3)10-16(4)12-18)25(23(28)24-22(19)27)13-17-8-6-5-7-9-17/h10-12,14,17H,5-9,13H2,1-4H3,(H,24,27,28)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473613
PNG
(US10844062, Example 49)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-6-3-5-16(11-17)26(37)35-18-8-9-20(28)21(12-18)36-24-19(7-4-10-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,36)(H,35,37)(H,31,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 10n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480643
PNG
(CHEMBL549900)
Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CCC2CC=CC2)c(=O)[nH]c1=O |c:21|
Show InChI InChI=1S/C23H28N2O3/c1-14(2)19-20(21(26)18-12-15(3)11-16(4)13-18)25(23(28)24-22(19)27)10-9-17-7-5-6-8-17/h5-6,11-14,17H,7-10H2,1-4H3,(H,24,27,28)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473640
PNG
(US10844062, Example 76)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)Cc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H17F4N7O/c26-18-7-6-16(11-19(18)36-20(37)10-14-3-1-4-15(9-14)25(27,28)29)35-23-17(5-2-8-30-23)21-22-24(33-12-31-21)34-13-32-22/h1-9,11-13H,10H2,(H,30,35)(H,36,37)(H,31,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473190
PNG
(US10844062, Example 1)
Show SMILES Fc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H14F5N7O/c25-15-6-7-16(35-23(37)12-3-1-4-13(9-12)24(27,28)29)17(26)19(15)36-21-14(5-2-8-30-21)18-20-22(33-10-31-18)34-11-32-20/h1-11H,(H,30,36)(H,35,37)(H,31,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480599
PNG
(CHEMBL550163)
Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(Cc2ccccc2)c(=O)[nH]c1=O
Show InChI InChI=1S/C23H24N2O3/c1-14(2)19-20(21(26)18-11-15(3)10-16(4)12-18)25(23(28)24-22(19)27)13-17-8-6-5-7-9-17/h5-12,14H,13H2,1-4H3,(H,24,27,28)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 11n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473594
PNG
(US10844062, Example 30)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H15F4N7O/c25-17-7-6-15(10-18(17)35-23(36)13-3-1-4-14(9-13)24(26,27)28)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 11n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473593
PNG
(US10844062, Example 29)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H21FN8O/c1-27(2,13-29)17-7-3-6-16(12-17)26(37)36-20-10-4-9-19(21(20)28)35-24-18(8-5-11-30-24)22-23-25(33-14-31-22)34-15-32-23/h3-12,14-15H,1-2H3,(H,30,35)(H,36,37)(H,31,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480613
PNG
(CHEMBL564867)
Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(CC2CC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C19H24N2O3/c1-11(2)16-17(22)20-19(23)21(10-14-5-6-14)18(16)24-15-8-12(3)7-13(4)9-15/h7-9,11,14H,5-6,10H2,1-4H3,(H,20,22,23)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 12n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473573
PNG
(US10844062, Example 9)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H20F2N8O/c1-27(2,12-30)16-6-3-5-15(11-16)26(38)36-19-9-8-18(28)22(20(19)29)37-24-17(7-4-10-31-24)21-23-25(34-13-32-21)35-14-33-23/h3-11,13-14H,1-2H3,(H,31,37)(H,36,38)(H,32,33,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473600
PNG
(US10844062, Example 36)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1F
Show InChI InChI=1S/C24H14F5N7O/c25-14-7-12(6-13(8-14)24(27,28)29)23(37)36-18-9-15(3-4-17(18)26)35-21-16(2-1-5-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473587
PNG
(US10844062, Example 23)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cccc(Nc2ncccc2-c2ncnc3[nH]cnc23)c1
Show InChI InChI=1S/C27H22N8O/c1-27(2,14-28)18-7-3-6-17(12-18)26(36)35-20-9-4-8-19(13-20)34-24-21(10-5-11-29-24)22-23-25(32-15-30-22)33-16-31-23/h3-13,15-16H,1-2H3,(H,29,34)(H,35,36)(H,30,31,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 14n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480645
PNG
(CHEMBL553470)
Show SMILES CCc1c(Oc2cc(C)cc(C)c2)n(CC2CC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C18H22N2O3/c1-4-15-16(21)19-18(22)20(10-13-5-6-13)17(15)23-14-8-11(2)7-12(3)9-14/h7-9,13H,4-6,10H2,1-3H3,(H,19,21,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 16n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480644
PNG
(CHEMBL560783)
Show SMILES CCc1c(Sc2cc(C)cc(C)c2)n(CC2CC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C18H22N2O2S/c1-4-15-16(21)19-18(22)20(10-13-5-6-13)17(15)23-14-8-11(2)7-12(3)9-14/h7-9,13H,4-6,10H2,1-3H3,(H,19,21,22)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480642
PNG
(CHEMBL561923)
Show SMILES CCc1c(C(=O)c2cc(C)cc(C)c2)n(CCC2CC=CC2)c(=O)[nH]c1=O |c:20|
Show InChI InChI=1S/C22H26N2O3/c1-4-18-19(20(25)17-12-14(2)11-15(3)13-17)24(22(27)23-21(18)26)10-9-16-7-5-6-8-16/h5-6,11-13,16H,4,7-10H2,1-3H3,(H,23,26,27)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 18n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480601
PNG
(CHEMBL559924)
Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CC2=CCCC2)c(=O)[nH]c1=O |t:18|
Show InChI InChI=1S/C22H26N2O3/c1-13(2)18-19(20(25)17-10-14(3)9-15(4)11-17)24(22(27)23-21(18)26)12-16-7-5-6-8-16/h7,9-11,13H,5-6,8,12H2,1-4H3,(H,23,26,27)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480615
PNG
(CHEMBL539429)
Show SMILES CCc1c(Sc2cc(C)cc(C)c2)n(CC2CCC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C19H24N2O2S/c1-4-16-17(22)20-19(23)21(11-14-6-5-7-14)18(16)24-15-9-12(2)8-13(3)10-15/h8-10,14H,4-7,11H2,1-3H3,(H,20,22,23)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480646
PNG
(CHEMBL562588)
Show SMILES CC(C)c1c(Sc2cc(C)cc(C)c2)n(CC2CCC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C20H26N2O2S/c1-12(2)17-18(23)21-20(24)22(11-15-6-5-7-15)19(17)25-16-9-13(3)8-14(4)10-16/h8-10,12,15H,5-7,11H2,1-4H3,(H,21,23,24)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 20n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473629
PNG
(US10844062, Example 65)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H14F7N7O/c26-17-4-3-15(38-21-16(2-1-5-33-21)19-20-22(36-10-34-19)37-11-35-20)9-18(17)39-23(40)12-6-13(24(27,28)29)8-14(7-12)25(30,31)32/h1-11H,(H,33,38)(H,39,40)(H,34,35,36,37)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473648
PNG
(US10844062, Example 84)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)c(F)cc1F
Show InChI InChI=1S/C28H21F2N7O/c1-28(2,14-31)17-6-3-5-16(11-17)27(38)37-23-13-22(20(29)12-21(23)30)36-26-18(7-4-9-32-26)24-19-8-10-33-25(19)35-15-34-24/h3-13,15H,1-2H3,(H,32,36)(H,37,38)(H,33,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 21n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480664
PNG
(CHEMBL560180)
Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CCC2CCC=C2)c(=O)[nH]c1=O |c:22|
Show InChI InChI=1S/C23H28N2O3/c1-14(2)19-20(21(26)18-12-15(3)11-16(4)13-18)25(23(28)24-22(19)27)10-9-17-7-5-6-8-17/h5,7,11-14,17H,6,8-10H2,1-4H3,(H,24,27,28)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480598
PNG
(CHEMBL552192)
Show SMILES CCc1c(C(=O)c2cc(C)cc(C)c2)n(Cc2ccccc2)c(=O)[nH]c1=O
Show InChI InChI=1S/C22H22N2O3/c1-4-18-19(20(25)17-11-14(2)10-15(3)12-17)24(22(27)23-21(18)26)13-16-8-6-5-7-9-16/h5-12H,4,13H2,1-3H3,(H,23,26,27)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 25n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480651
PNG
(CHEMBL559788)
Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(CCC2CCC=C2)c(=O)[nH]c1=O |c:21|
Show InChI InChI=1S/C22H28N2O3/c1-14(2)19-20(25)23-22(26)24(10-9-17-7-5-6-8-17)21(19)27-18-12-15(3)11-16(4)13-18/h5,7,11-14,17H,6,8-10H2,1-4H3,(H,23,25,26)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 27n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473642
PNG
(US10844062, Example 78)
Show SMILES Fc1cc(NC(=O)c2ccc(CC#N)cc2)ccc1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C25H17FN8O/c26-19-12-17(33-25(35)16-5-3-15(4-6-16)9-10-27)7-8-20(19)34-23-18(2-1-11-28-23)21-22-24(31-13-29-21)32-14-30-22/h1-8,11-14H,9H2,(H,28,34)(H,33,35)(H,29,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a 28n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473596
PNG
(US10844062, Example 32)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)c(F)cc1F
Show InChI InChI=1S/C27H20F2N8O/c1-27(2,12-30)16-6-3-5-15(9-16)26(38)37-21-11-20(18(28)10-19(21)29)36-24-17(7-4-8-31-24)22-23-25(34-13-32-22)35-14-33-23/h3-11,13-14H,1-2H3,(H,31,36)(H,37,38)(H,32,33,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 29n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480627
PNG
(CHEMBL558404)
Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(CC2=CCCC2)c(=O)[nH]c1=O |t:17|
Show InChI InChI=1S/C21H26N2O3/c1-13(2)18-19(24)22-21(25)23(12-16-7-5-6-8-16)20(18)26-17-10-14(3)9-15(4)11-17/h7,9-11,13H,5-6,8,12H2,1-4H3,(H,22,24,25)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 32n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473641
PNG
(US10844062, Example 77)
Show SMILES Fc1ccc(cc1Nc1ncccc1-c1ncnc2[nH]cnc12)C(=O)Nc1cccc(CC#N)c1
Show InChI InChI=1S/C25H17FN8O/c26-19-7-6-16(25(35)33-17-4-1-3-15(11-17)8-9-27)12-20(19)34-23-18(5-2-10-28-23)21-22-24(31-13-29-21)32-14-30-22/h1-7,10-14H,8H2,(H,28,34)(H,33,35)(H,29,30,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473631
PNG
(US10844062, Example 67)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1Cl
Show InChI InChI=1S/C24H14ClF4N7O/c25-17-4-3-15(9-18(17)36-23(37)12-6-13(24(27,28)29)8-14(26)7-12)35-21-16(2-1-5-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H,36,37)(H,31,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 40n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473638
PNG
(US10844062, Example 74)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1NC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C24H15ClF4N8O/c25-16-5-3-12(8-15(16)24(27,28)29)36-23(38)37-18-9-13(4-6-17(18)26)35-21-14(2-1-7-30-21)19-20-22(33-10-31-19)34-11-32-20/h1-11H,(H,30,35)(H2,36,37,38)(H,31,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 43n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473637
PNG
(US10844062, Example 73)
Show SMILES Fc1ccc(Nc2ncccc2-c2ncnc3[nH]cnc23)cc1C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H15F4N7O/c25-18-7-6-15(10-17(18)23(36)35-14-4-1-3-13(9-14)24(26,27)28)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 52n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480634
PNG
(CHEMBL550386)
Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CCC2CCCC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C23H30N2O3/c1-14(2)19-20(21(26)18-12-15(3)11-16(4)13-18)25(23(28)24-22(19)27)10-9-17-7-5-6-8-17/h11-14,17H,5-10H2,1-4H3,(H,24,27,28)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 65n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Reverse transcriptase protein


(Human immunodeficiency virus 1)		BDBM50480613
PNG
(CHEMBL564867)
Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(CC2CC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C19H24N2O3/c1-11(2)16-17(22)20-19(23)21(10-14-5-6-14)18(16)24-15-8-12(3)7-13(4)9-15/h7-9,11,14H,5-6,10H2,1-4H3,(H,20,22,23)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 67n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of HIV1 reverse transcriptase K103N mutant assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480618
PNG
(CHEMBL562879)
Show SMILES CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CC2CCC2)c(=O)[nH]c1=O
Show InChI InChI=1S/C21H26N2O3/c1-12(2)17-18(19(24)16-9-13(3)8-14(4)10-16)23(11-15-6-5-7-15)21(26)22-20(17)25/h8-10,12,15H,5-7,11H2,1-4H3,(H,22,25,26)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 68n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473592
PNG
(US10844062, Example 28)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C24H13F6N7O/c25-13-7-11(6-12(8-13)24(28,29)30)23(38)36-16-4-3-15(26)19(17(16)27)37-21-14(2-1-5-31-21)18-20-22(34-9-32-18)35-10-33-20/h1-10H,(H,31,37)(H,36,38)(H,32,33,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 74n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480639
PNG
(CHEMBL549428)
Show SMILES CCc1c(C(=O)c2cc(C)cc(C)c2)n(CCC2CCC=C2)c(=O)[nH]c1=O |c:21|
Show InChI InChI=1S/C22H26N2O3/c1-4-18-19(20(25)17-12-14(2)11-15(3)13-17)24(22(27)23-21(18)26)10-9-16-7-5-6-8-16/h5,7,11-13,16H,4,6,8-10H2,1-3H3,(H,23,26,27)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 75n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473653
PNG
(US10844062, Example 91)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)ccc1F
Show InChI InChI=1S/C28H22FN7O/c1-28(2,15-30)18-6-3-5-17(13-18)27(37)36-23-14-19(8-9-22(23)29)35-26-20(7-4-11-31-26)24-21-10-12-32-25(21)34-16-33-24/h3-14,16H,1-2H3,(H,31,35)(H,36,37)(H,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 76n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480626
PNG
(CHEMBL539400)
Show SMILES CC(C)c1c(Sc2cc(C)cc(C)c2)n(CC2=CCCC2)c(=O)[nH]c1=O |t:17|
Show InChI InChI=1S/C21H26N2O2S/c1-13(2)18-19(24)22-21(25)23(12-16-7-5-6-8-16)20(18)26-17-10-14(3)9-15(4)11-17/h7,9-11,13H,5-6,8,12H2,1-4H3,(H,22,24,25)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 79n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473605
PNG
(US10844062, Example 41)
Show SMILES CC(C)(C#N)c1cc(ccc1Cl)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C27H19ClF2N8O/c1-27(2,11-31)16-10-14(5-6-17(16)28)26(39)37-19-8-7-18(29)22(20(19)30)38-24-15(4-3-9-32-24)21-23-25(35-12-33-21)36-13-34-23/h3-10,12-13H,1-2H3,(H,32,38)(H,37,39)(H,33,34,35,36)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 82n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473654
PNG
(US10844062, Example 92)
Show SMILES CC(C)(C#N)c1cc(F)cc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)ccc1F
Show InChI InChI=1S/C28H21F2N7O/c1-28(2,14-31)17-10-16(11-18(29)12-17)27(38)37-23-13-19(5-6-22(23)30)36-26-20(4-3-8-32-26)24-21-7-9-33-25(21)35-15-34-24/h3-13,15H,1-2H3,(H,32,36)(H,37,38)(H,33,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 87n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480656
PNG
(CHEMBL559205)
Show SMILES CCc1c(C(=O)c2cc(C)cc(C)c2)n(CC2=CCCC2)c(=O)[nH]c1=O |t:17|
Show InChI InChI=1S/C21H24N2O3/c1-4-17-18(19(24)16-10-13(2)9-14(3)11-16)23(21(26)22-20(17)25)12-15-7-5-6-8-15/h7,9-11H,4-6,8,12H2,1-3H3,(H,22,25,26)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 88n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473630
PNG
(US10844062, Example 66)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]cnc23)ccc1Cl
Show InChI InChI=1S/C24H15ClF3N7O/c25-17-7-6-15(10-18(17)35-23(36)13-3-1-4-14(9-13)24(26,27)28)34-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,34)(H,35,36)(H,30,31,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 89n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473649
PNG
(US10844062, Example 85)
Show SMILES CC(C)(C#N)c1cccc(c1)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]ccc23)c1F
Show InChI InChI=1S/C28H21F2N7O/c1-28(2,14-31)17-6-3-5-16(13-17)27(38)36-21-9-8-20(29)24(22(21)30)37-26-18(7-4-11-32-26)23-19-10-12-33-25(19)35-15-34-23/h3-13,15H,1-2H3,(H,32,37)(H,36,38)(H,33,34,35)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 89n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473614
PNG
(US10844062, Example 50)
Show SMILES Fc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1ncccc1-c1ncnc2[nH]cnc12
Show InChI InChI=1S/C24H15F4N7O/c25-17-7-6-15(34-23(36)13-3-1-4-14(9-13)24(26,27)28)10-18(17)35-21-16(5-2-8-29-21)19-20-22(32-11-30-19)33-12-31-20/h1-12H,(H,29,35)(H,34,36)(H,30,31,32,33)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 90n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480597
PNG
(CHEMBL559529)
Show SMILES CCc1c(Oc2cc(C)cc(C)c2)n(Cc2ccccc2)c(=O)[nH]c1=O
Show InChI InChI=1S/C21H22N2O3/c1-4-18-19(24)22-21(25)23(13-16-8-6-5-7-9-16)20(18)26-17-11-14(2)10-15(3)12-17/h5-12H,4,13H2,1-3H3,(H,22,24,25)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 95n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473604
PNG
(US10844062, Example 40)
Show SMILES [O-][N+](=O)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F
Show InChI InChI=1S/C24H13F5N8O3/c25-15-3-4-16(35-23(38)11-6-12(24(27,28)29)8-13(7-11)37(39)40)17(26)19(15)36-21-14(2-1-5-30-21)18-20-22(33-9-31-18)34-10-32-20/h1-10H,(H,30,36)(H,35,38)(H,31,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 96n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM473652
PNG
(US10844062, Example 88)
Show SMILES Fc1cc(cc(c1)C(F)(F)F)C(=O)Nc1cc(Nc2ncccc2-c2ncnc3[nH]ccc23)ccc1F
Show InChI InChI=1S/C25H15F5N6O/c26-15-9-13(8-14(10-15)25(28,29)30)24(37)36-20-11-16(3-4-19(20)27)35-23-17(2-1-6-31-23)21-18-5-7-32-22(18)34-12-33-21/h1-12H,(H,31,35)(H,36,37)(H,32,33,34)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 109n/an/an/an/an/an/a



Incheon University Industry Academic Cooperation Foundation; Samjin Pharmaceutical Co., Ltd.; Bamichem Co., Ltd.

US Patent


Assay Description
The inhibitory activities of the compounds of the present invention against VEGFR-2 tyrosine kinase were analyzed using ADP-Glo™ kinase assay kit com...

US Patent US10844062 (2020)


BindingDB Entry DOI: 10.7270/Q2NG4TRN
More data for this
Ligand-Target Pair
Histone deacetylase


(Homo sapiens (Human))		BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
Article
PubMed
n/an/a 110n/an/an/an/an/an/a



KRIBB

Curated by ChEMBL


Assay Description
Inhibition of HDAC in HeLa cells by fluorescent activity assay

J Med Chem 50: 2737-41 (2007)


Article DOI: 10.1021/jm0613828
BindingDB Entry DOI: 10.7270/Q2833VTC
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Reverse transcriptase


(Human immunodeficiency virus 1)		BDBM50480625
PNG
(CHEMBL562570)
Show SMILES CC(C)c1c(Oc2cc(C)cc(C)c2)n(Cc2ccccc2)c(=O)[nH]c1=O
Show InChI InChI=1S/C22H24N2O3/c1-14(2)19-20(25)23-22(26)24(13-17-8-6-5-7-9-17)21(19)27-18-11-15(3)10-16(4)12-18/h5-12,14H,13H2,1-4H3,(H,23,25,26)
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 114n/an/an/an/an/an/a



ImQuest BioSciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of wild type HIV1 reverse transcriptase assessed as 32P-labeled GMP incorporation into nascent DNA strand

Antimicrob Agents Chemother 52: 225-36 (2008)


Article DOI: 10.1128/aac.00972-07
BindingDB Entry DOI: 10.7270/Q2JM2DFB
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 257 total )  |  Next  |  Last  >>
Jump to: