Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neutrophil collagenase (Homo sapiens (Human)) | BDBM12072 ((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 0.600 | -52.6 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM12075 ((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 4.40 | -47.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM12072 ((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 5 | -47.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM12072 ((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 40 | -42.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM12074 ((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 54.9 | -41.4 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM28681 (5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 74 | -40.3 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Consiglio Nazionale delle Ricerche | Assay Description The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros... | J Biol Chem 282: 17314-24 (2007) Article DOI: 10.1074/jbc.M702316200 BindingDB Entry DOI: 10.7270/Q27M0682 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM28681 (5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Tumori"Giovanni Paolo II" Curated by ChEMBL | Assay Description Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc... | J Med Chem 55: 37-54 (2012) Article DOI: 10.1021/jm201306q BindingDB Entry DOI: 10.7270/Q23N24JP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM28762 ((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 88 | -39.9 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Consiglio Nazionale delle Ricerche | Assay Description The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros... | J Biol Chem 282: 17314-24 (2007) Article DOI: 10.1074/jbc.M702316200 BindingDB Entry DOI: 10.7270/Q27M0682 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM28762 ((2R)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 88 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Tumori"Giovanni Paolo II" Curated by ChEMBL | Assay Description Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc... | J Med Chem 55: 37-54 (2012) Article DOI: 10.1021/jm201306q BindingDB Entry DOI: 10.7270/Q23N24JP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Neutrophil collagenase (Homo sapiens (Human)) | BDBM12073 ((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 700 | -35.1 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM28763 ((2S)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 971 | -34.0 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Consiglio Nazionale delle Ricerche | Assay Description The scintillation proximity assay was performed in 96-well plates containing polylysine-coated yttrium silicate beads, His-PPARgamma-LBD, and [3H]ros... | J Biol Chem 282: 17314-24 (2007) Article DOI: 10.1074/jbc.M702316200 BindingDB Entry DOI: 10.7270/Q27M0682 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM28763 ((2S)-2-(4-{2-[1,3-benzoxazol-2-yl(heptyl)amino]eth...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | 971 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Istituto Tumori"Giovanni Paolo II" Curated by ChEMBL | Assay Description Displacement of [3H]rosiglitazone from N-terminal His-tagged human PPARgamma ligand binding domain expressed in Escherichia coli BL21 DE3 cells by sc... | J Med Chem 55: 37-54 (2012) Article DOI: 10.1021/jm201306q BindingDB Entry DOI: 10.7270/Q23N24JP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM12073 ((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 1.20E+3 | -33.8 | n/a | n/a | n/a | n/a | n/a | 7.5 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM8485 ((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM12076 ((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM12075 ((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM8485 ((2R)-N-hydroxy-3-methyl-2-[(4-phenoxybenzene)sulfo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 6.0 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM12074 ((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-3-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil collagenase (Homo sapiens (Human)) | BDBM27878 (13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 7.40 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50030474 (Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of SMRT incubated for 16 hrs by luciferase reporter... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01555 BindingDB Entry DOI: 10.7270/Q20V8HGR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM12076 ((2R)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | 6.0 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Collagenase 3 (Homo sapiens (Human)) | BDBM27877 (N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | <25 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Collagenase 3 (Homo sapiens (Human)) | BDBM27878 (13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | <25 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil collagenase (Homo sapiens (Human)) | BDBM27877 (N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents | MMDB PDB Article PubMed | n/a | n/a | 57 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50030474 (Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars | DrugBank PDB Article PubMed | n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of NCoR incubated for 16 hrs by luciferase reporter... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01555 BindingDB Entry DOI: 10.7270/Q20V8HGR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM27877 (N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | <100 | n/a | n/a | n/a | n/a | 6.0 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM12077 ((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 450 | n/a | n/a | n/a | n/a | 7.0 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM12077 ((2S)-2-{[4-(4-bromophenyl)benzene]sulfonamido}-N-h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 810 | n/a | n/a | n/a | n/a | 6.0 | 25 |
Istituto di Cristallografia | Assay Description Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ... | J Med Chem 49: 923-31 (2006) Article DOI: 10.1021/jm050787+ BindingDB Entry DOI: 10.7270/Q2348HM7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50554669 (CHEMBL4743677) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 956 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of NCoR incubated for 16 hrs by luciferase reporter... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01555 BindingDB Entry DOI: 10.7270/Q20V8HGR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Peroxisome proliferator-activated receptor gamma (Homo sapiens (Human)) | BDBM50554669 (CHEMBL4743677) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 2.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at PPARg-LBD (unknown origin) expressed in HEK293 cells assessed as displacement of SMRT incubated for 16 hrs by luciferase reporter... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01555 BindingDB Entry DOI: 10.7270/Q20V8HGR | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM27878 (13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | 6.0 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM27877 (N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >2.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage metalloelastase (Homo sapiens (Human)) | BDBM27877 (N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interstitial collagenase (Homo sapiens (Human)) | BDBM27878 (13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM27878 (13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Interstitial collagenase (Homo sapiens (Human)) | BDBM27877 (N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-14 (Homo sapiens (Human)) | BDBM27878 (13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-14 (Homo sapiens (Human)) | BDBM27877 (N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Macrophage metalloelastase (Homo sapiens (Human)) | BDBM27878 (13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-9 (Homo sapiens (Human)) | BDBM27878 (13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrix metalloproteinase-9 (Homo sapiens (Human)) | BDBM27877 (N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrilysin (Homo sapiens (Human)) | BDBM27877 (N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Matrilysin (Homo sapiens (Human)) | BDBM27878 (13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Universita degli Studi | Assay Description Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr... | J Med Chem 52: 1040-9 (2009) Article DOI: 10.1021/jm801166j BindingDB Entry DOI: 10.7270/Q28S4N80 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50175780 (CHEMBL200435 | N-{2-[(4'-cyano-1,1'-biphenyl-4-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi 'G. d'Annunzio' Curated by ChEMBL | Assay Description Inhibitory activity against MMP2 | Bioorg Med Chem Lett 16: 20-4 (2005) Article DOI: 10.1016/j.bmcl.2005.09.057 BindingDB Entry DOI: 10.7270/Q2K9372X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM50100898 (CHEMBL41928 | N-{2-[(4'-cyano-1,1'-biphenyl-4-yl)o...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi 'G. d'Annunzio' Curated by ChEMBL | Assay Description Inhibitory activity against MMP3 | Bioorg Med Chem Lett 16: 20-4 (2005) Article DOI: 10.1016/j.bmcl.2005.09.057 BindingDB Entry DOI: 10.7270/Q2K9372X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50100898 (CHEMBL41928 | N-{2-[(4'-cyano-1,1'-biphenyl-4-yl)o...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi 'G. d'Annunzio' Curated by ChEMBL | Assay Description Inhibitory activity against MMP2 | Bioorg Med Chem Lett 16: 20-4 (2005) Article DOI: 10.1016/j.bmcl.2005.09.057 BindingDB Entry DOI: 10.7270/Q2K9372X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil collagenase (Homo sapiens (Human)) | BDBM50100898 (CHEMBL41928 | N-{2-[(4'-cyano-1,1'-biphenyl-4-yl)o...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.20E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi 'G. d'Annunzio' Curated by ChEMBL | Assay Description Inhibitory activity against MMP8 | Bioorg Med Chem Lett 16: 20-4 (2005) Article DOI: 10.1016/j.bmcl.2005.09.057 BindingDB Entry DOI: 10.7270/Q2K9372X | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (docked) | ||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM50175780 (CHEMBL200435 | N-{2-[(4'-cyano-1,1'-biphenyl-4-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi 'G. d'Annunzio' Curated by ChEMBL | Assay Description Inhibitory activity against MMP3 | Bioorg Med Chem Lett 16: 20-4 (2005) Article DOI: 10.1016/j.bmcl.2005.09.057 BindingDB Entry DOI: 10.7270/Q2K9372X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Stromelysin-1 (Homo sapiens (Human)) | BDBM50175782 (1-(4-phenoxyphenethyl)-3-hydroxy-1-methylurea | CH...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi 'G. d'Annunzio' Curated by ChEMBL | Assay Description Inhibitory activity against MMP3 | Bioorg Med Chem Lett 16: 20-4 (2005) Article DOI: 10.1016/j.bmcl.2005.09.057 BindingDB Entry DOI: 10.7270/Q2K9372X | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
72 kDa type IV collagenase (Homo sapiens (Human)) | BDBM50175781 (1-(4-phenoxyphenethyl)-3-hydroxyurea | CHEMBL19792...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >3.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Università degli Studi 'G. d'Annunzio' Curated by ChEMBL | Assay Description Inhibitory activity against MMP2 | Bioorg Med Chem Lett 16: 20-4 (2005) Article DOI: 10.1016/j.bmcl.2005.09.057 BindingDB Entry DOI: 10.7270/Q2K9372X | |||||||||||
More data for this Ligand-Target Pair |
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