Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin E2 receptor EP1 subtype (Homo sapiens (Human)) | BDBM50160917![]() (3-(3-(2-(benzyloxy)-5-chlorophenyl)thiophen-2-yl)b...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Antagonist activity against PGE2 activated EP1 receptor assessed as ability to inhibit intracellular calcium mobilisation by FLIPR | Bioorg Med Chem Lett 16: 2666-71 (2006) Article DOI: 10.1016/j.bmcl.2006.02.014 BindingDB Entry DOI: 10.7270/Q2J102RM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451038![]() (8-(4-((dimethylamino)methyl)phenyl)-N-(2-fluoro- |...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451065![]() (US10676479, Example 95 | ethyl 5-(((5-fluoro-2,3-d...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451070![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)- |...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451062![]() (US10676479, Example 92 | ethyl 5-(((5-fluoro-2,3-d...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291686![]() (8-(1,3-Dimethyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291686![]() (8-(1,3-Dimethyl-1H-pyrazol-5-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291695![]() (3-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291695![]() (3-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291815![]() ((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291815![]() ((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291925![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291925![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291908![]() (8-(6-((dimethylamino)methyl)-2-methylpyridin-3-yl)...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291908![]() (8-(6-((dimethylamino)methyl)-2-methylpyridin-3-yl)...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291909![]() (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291909![]() (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291824![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291824![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291824![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291824![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291823![]() (8-(4-chloro-6-methoxypyridin-3-yl)-N-((5-fluoro-2,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291823![]() (8-(4-chloro-6-methoxypyridin-3-yl)-N-((5-fluoro-2,...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291814![]() ((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291814![]() ((5-(5-(((5-fluoro-2,3-dihydrobenzofuran-4-yl)methy...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291909![]() (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291909![]() (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291853![]() (8-(2-(difluoromethyl)pyridin-3-yl)-N-((5-fluoro-2,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291918![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291918![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM450978![]() (1-Chloro-8-(2,4-dimethylpyrimidin-5-yl)-N-((5-fluo...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451065![]() (US10676479, Example 95 | ethyl 5-(((5-fluoro-2,3-d...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291853![]() (8-(2-(difluoromethyl)pyridin-3-yl)-N-((5-fluoro-2,...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291689![]() (N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291689![]() (N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451074![]() (8-(2,4-dimethylpyrimidin-5-yl)-1-(ethylsulfonyl)- ...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291882![]() (8-(6-(difluoromethoxy)-4-methylpyridin-3-yl)-N-((5...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291882![]() (8-(6-(difluoromethoxy)-4-methylpyridin-3-yl)-N-((5...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291909![]() (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Representative compounds of the present disclosure were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentra... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291909![]() (8-(6-ethyl-4-methylpyridin-3-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291873![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Polycomb protein EED (Homo sapiens (Human)) | BDBM291873![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | Citation and Details BindingDB Entry DOI: 10.7270/Q29W0JNH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451053![]() (8-(2-(3,5-dimethylpiperazin-1-yl)-4- | US10676479,...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM450981![]() (8-(2-(Difluoromethyl)pyridin-3-yl)-N-((5-fluoro-2,...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451054![]() (5-(((5-fluoro-2,3-dihydrobenzofuran-4- | US1067647...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description To assess the compounds' potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total ... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291880![]() (8-(1,3-dimethyl-1H-pyrazol-4-yl)-N-((5-fluoro-2,3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Cell lysates were transferred to the wells of a 384-well plate and the final volume was adjusted to 50 μL per well with PBS. The plate was seale... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM451072![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)- |...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description Representative compounds of the present invention were serially and separately diluted 3-fold in DMSO to obtain a total of eight or twelve concentrat... | US Patent US10676479 (2020) BindingDB Entry DOI: 10.7270/Q2TQ64M9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291827![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291830![]() (N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12 (Homo sapiens (Human)) | BDBM291879![]() (8-(2,5-dimethylpyridin-4-yl)-N-((5-fluoro-2,3-dihy...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Novartis AG US Patent | Assay Description To assess the compounds potency in the EED-H3K27Me3 competition binding assay, compounds were serially diluted 3-fold in DMSO to obtain a total of tw... | US Patent US9580437 (2017) BindingDB Entry DOI: 10.7270/Q24T6MD7 | |||||||||||
More data for this Ligand-Target Pair |
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