BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 815 hits with Last Name = 'conte' and Initial = 'i'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein/Non-structural protein 4A


(Hepatitis C virus)		BDBM50110121
PNG
(3-[2-(2-{2-[2-(2-Acetylamino-3-carboxy-propionylam...)
Show SMILES CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](CC(F)F)C(=O)C(O)=O
Show InChI InChI=1S/C45H56F2N6O15/c1-24(54)48-32(23-36(59)60)43(65)49-29(18-20-35(57)58)41(63)53-38(37(26-13-7-3-8-14-26)27-15-9-4-10-16-27)44(66)50-28(17-19-34(55)56)40(62)52-31(21-25-11-5-2-6-12-25)42(64)51-30(22-33(46)47)39(61)45(67)68/h3-4,7-10,13-16,25,28-33,37-38H,2,5-6,11-12,17-23H2,1H3,(H,48,54)(H,49,65)(H,50,66)(H,51,64)(H,52,62)(H,53,63)(H,55,56)(H,57,58)(H,59,60)(H,67,68)/t28-,29-,30-,31-,32-,38-/m0/s1
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 0.0100n/an/an/an/an/an/an/an/a



IRBM, MRL Rome

Curated by ChEMBL


Assay Description
Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine protease

Bioorg Med Chem Lett 12: 705-8 (2002)


BindingDB Entry DOI: 10.7270/Q24X572V
More data for this
Ligand-Target Pair
Genome polyprotein/Non-structural protein 4A


(Hepatitis C virus)		BDBM50110117
PNG
(4-(2-Acetylamino-3-carboxy-propionylamino)-4-(1-{3...)
Show SMILES CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](CC(F)F)C=O
Show InChI InChI=1S/C44H56F2N6O13/c1-25(54)47-33(23-37(59)60)43(64)49-31(18-20-36(57)58)41(62)52-39(38(27-13-7-3-8-14-27)28-15-9-4-10-16-28)44(65)50-30(17-19-35(55)56)40(61)51-32(21-26-11-5-2-6-12-26)42(63)48-29(24-53)22-34(45)46/h3-4,7-10,13-16,24,26,29-34,38-39H,2,5-6,11-12,17-23H2,1H3,(H,47,54)(H,48,63)(H,49,64)(H,50,65)(H,51,61)(H,52,62)(H,55,56)(H,57,58)(H,59,60)/t29-,30-,31-,32-,33-,39-/m0/s1
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 0.5n/an/an/an/an/an/an/an/a



IRBM, MRL Rome

Curated by ChEMBL


Assay Description
Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine protease

Bioorg Med Chem Lett 12: 705-8 (2002)


BindingDB Entry DOI: 10.7270/Q24X572V
More data for this
Ligand-Target Pair
Genome polyprotein/Non-structural protein 4A


(Hepatitis C virus)		BDBM50110125
PNG
(2-[2-(2-{2-[2-(2-Acetylamino-3-carboxy-propionylam...)
Show SMILES CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1CCCCC1)C(=O)N[C@@H](CC(F)F)C(O)=O
Show InChI InChI=1S/C44H56F2N6O14/c1-24(53)47-31(23-36(58)59)42(63)48-29(18-20-35(56)57)40(61)52-38(37(26-13-7-3-8-14-26)27-15-9-4-10-16-27)43(64)49-28(17-19-34(54)55)39(60)50-30(21-25-11-5-2-6-12-25)41(62)51-32(44(65)66)22-33(45)46/h3-4,7-10,13-16,25,28-33,37-38H,2,5-6,11-12,17-23H2,1H3,(H,47,53)(H,48,63)(H,49,64)(H,50,60)(H,51,62)(H,52,61)(H,54,55)(H,56,57)(H,58,59)(H,65,66)/t28-,29-,30-,31-,32-,38-/m0/s1
PDB

UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
 40n/an/an/an/an/an/an/an/a



IRBM, MRL Rome

Curated by ChEMBL


Assay Description
Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine protease

Bioorg Med Chem Lett 12: 705-8 (2002)


BindingDB Entry DOI: 10.7270/Q24X572V
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM50162108
PNG
(3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHE...)
Show SMILES OC(=O)c1ccc2c(C3CCCCC3)c(-c3ccccc3)n(CC(=O)N3CCOCC3)c2c1
Show InChI InChI=1S/C27H30N2O4/c30-24(28-13-15-33-16-14-28)18-29-23-17-21(27(31)32)11-12-22(23)25(19-7-3-1-4-8-19)26(29)20-9-5-2-6-10-20/h2,5-6,9-12,17,19H,1,3-4,7-8,13-16,18H2,(H,31,32)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents

Similars
Article
PubMed
n/an/a 26n/an/an/an/an/an/a



MRL Rome

Curated by ChEMBL


Assay Description
Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase

Bioorg Med Chem Lett 16: 4026-30 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.012
BindingDB Entry DOI: 10.7270/Q2416WP6
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM50158845
PNG
(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1sccc1NC(=O)NCc1ccccc1Cl
Show InChI InChI=1S/C17H13ClN4O5S/c18-9-4-2-1-3-8(9)7-19-17(27)20-10-5-6-28-13(10)14-21-11(16(25)26)12(23)15(24)22-14/h1-6,23H,7H2,(H,25,26)(H2,19,20,27)(H,21,22,24)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 36n/an/an/an/an/an/a



P. Angeletti S.p.A. (Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HCV 1b BK NS5B deltaC55 RNA polymerase involving manganese chelation

J Med Chem 49: 1693-705 (2006)


Article DOI: 10.1021/jm051064t
BindingDB Entry DOI: 10.7270/Q2QJ7GWR
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM50158845
PNG
(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1sccc1NC(=O)NCc1ccccc1Cl
Show InChI InChI=1S/C17H13ClN4O5S/c18-9-4-2-1-3-8(9)7-19-17(27)20-10-5-6-28-13(10)14-21-11(16(25)26)12(23)15(24)22-14/h1-6,23H,7H2,(H,25,26)(H2,19,20,27)(H,21,22,24)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 44n/an/an/an/an/an/a



P. Angeletti S.p.A. (Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HCV 2a BK NS5B deltaC21 RNA polymerase

J Med Chem 49: 1693-705 (2006)


Article DOI: 10.1021/jm051064t
BindingDB Entry DOI: 10.7270/Q2QJ7GWR
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM50158845
PNG
(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1sccc1NC(=O)NCc1ccccc1Cl
Show InChI InChI=1S/C17H13ClN4O5S/c18-9-4-2-1-3-8(9)7-19-17(27)20-10-5-6-28-13(10)14-21-11(16(25)26)12(23)15(24)22-14/h1-6,23H,7H2,(H,25,26)(H2,19,20,27)(H,21,22,24)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 45n/an/an/an/an/an/a



P. Angeletti S.p.A. (Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HCV 1b BK NS5B deltaC21 RNA polymerase

J Med Chem 49: 1693-705 (2006)


Article DOI: 10.1021/jm051064t
BindingDB Entry DOI: 10.7270/Q2QJ7GWR
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM50162094
PNG
(3-Cyclohexyl-2-phenyl-1H-indole-6-carboxylic acid ...)
Show SMILES OC(=O)c1ccc2c(C3CCCCC3)c([nH]c2c1)-c1ccccc1
Show InChI InChI=1S/C21H21NO2/c23-21(24)16-11-12-17-18(13-16)22-20(15-9-5-2-6-10-15)19(17)14-7-3-1-4-8-14/h2,5-6,9-14,22H,1,3-4,7-8H2,(H,23,24)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 48n/an/an/an/an/an/a



MRL Rome

Curated by ChEMBL


Assay Description
Inhibition of HCV BK NS5B deltaC55 RNA dependent RNA polymerase

Bioorg Med Chem Lett 16: 4026-30 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.012
BindingDB Entry DOI: 10.7270/Q2416WP6
More data for this
Ligand-Target Pair
RNA-directed RNA polymerase


(Hepatitis C virus)		BDBM50158845
PNG
(2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-...)
Show SMILES OC(=O)c1nc([nH]c(=O)c1O)-c1sccc1NC(=O)NCc1ccccc1Cl
Show InChI InChI=1S/C17H13ClN4O5S/c18-9-4-2-1-3-8(9)7-19-17(27)20-10-5-6-28-13(10)14-21-11(16(25)26)12(23)15(24)22-14/h1-6,23H,7H2,(H,25,26)(H2,19,20,27)(H,21,22,24)
PDB

UniProtKB/TrEMBL

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 48n/an/an/an/an/an/a



P. Angeletti S.p.A. (Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against HCV 3a BK NS5B deltaC21 RNA polymerase

J Med Chem 49: 1693-705 (2006)


Article DOI: 10.1021/jm051064t
BindingDB Entry DOI: 10.7270/Q2QJ7GWR
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586427
PNG
(US11530244, Compound 424)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@@H](C)NC(=O)[C@H](CNC(=O)COCCN)NC(=O)CCSCc3cccc(CSCCNC(=O)[C@]4(C)CCCN4C2=O)c3)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM50554747
PNG
(CHEMBL4756880 | US11530244, Compound 425)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCC(O)=O)NC(=O)CCSCc3cccc(CSCCNC(=O)[C@]4(C)CCCN4C2=O)c3)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586434
PNG
(US11530244, Compound 431)
Show SMILES CC(=O)N[C@H]1CCCC\C=C\CO[C@H]2C[C@H](N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)CNC(=O)[C@H](CCCCN)NC1=O)C(N)=O |r,t:9|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586438
PNG
(US11530244, Compound 435)
Show SMILES CC1NC(=O)CCS(=O)Cc2cccc(CS(=O)C[C@H](NC(=O)[C@]3(C)CCCN3C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)c3cnc1s3)C(N)=O)c2 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586440
PNG
(US11530244, Compound 437)
Show SMILES NC(=O)[C@@H]1Cc2ccc(CNC(=O)CCCC(=O)NCC(=O)N[C@@H](Cc3c[nH]c4ccc(F)cc34)C(=O)N[C@@H](Cc3c[nH]c4ccc(F)cc34)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3cnc[nH]3)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N1)cc2 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586445
PNG
(US11530244, Compound 442)
Show SMILES CCCCCC[C@@H]1NC(=O)CCSCc2cccc(CSCCNC(=O)[C@]3(C)CCCN3C(=O)[C@H](Cc3ccc(OC)cc3)NC(=O)[C@H](Cc3ncc[nH]3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@@H](C)NC1=O)c2 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586450
PNG
(US11530244, Compound 447 | US11530244, Compound 44...)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@H](Cc3ncc[nH]3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@@H](C)NC(=O)[C@H](CNC(=O)COCCOCCN)NC(=O)CCSCc3cccc(CSCCNC(=O)[C@]4(C)CCCN4C2=O)c3)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586455
PNG
(US11530244, Compound 452)
Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)CCSCc2cccc(CSC[C@H](NC(=O)[C@]3(C)CCCN3C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC1=O)C(N)=O)c2)C(O)=O |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586456
PNG
(US11530244, Compound 453)
Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCc1ccc(C[C@@H]2NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCSCc3cccc(CSC[C@H](NC(=O)[C@]4(C)CCCN4C(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC2=O)C(N)=O)c3)cc1)C(O)=O |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586457
PNG
(US11530244, Compound 454 | US11530244, Compound 47...)
Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCc1cccc(C[C@@H]2NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCSCc3cccc(CSC[C@H](NC(=O)[C@]4(C)CCCN4C(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC2=O)C(N)=O)c3)c1)C(O)=O |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586463
PNG
(US11530244, Compound 460)
Show SMILES C[C@@H]1NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCSCc2cccc(CSC[C@H](NC(=O)[C@]3(C)CCCN3C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)c3cnc1s3)C(N)=O)c2 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586472
PNG
(US11530244, Compound 470)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](C)NC(=O)CCCCCC(=O)NCc3ccc(CCNC(=O)[C@]4(C)CCCN4C2=O)cc3)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586473
PNG
(US11530244, Compound 471)
Show SMILES CC(=O)N[C@@H]1CCCC\C=C/CO[C@@H]2CCN([C@@H]2C(N)=O)C(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)[C@H](Cc2c[nH]c3ccc(F)cc23)NC(=O)CNC1=O |r,c:9|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586474
PNG
(US11530244, Compound 472)
Show SMILES CC(C)C[C@@H]1[N@@]2CC[C@H](NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)CCSCc3cccc(CSC[C@H](NC(=O)[C@]4(C)CCCN4C(=O)[C@H](Cc4ccc(O)cc4)NC1=O)C(N)=O)c3)C2=O |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586457
PNG
(US11530244, Compound 454 | US11530244, Compound 47...)
Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCc1cccc(C[C@@H]2NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCSCc3cccc(CSC[C@H](NC(=O)[C@]4(C)CCCN4C(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC2=O)C(N)=O)c3)c1)C(O)=O |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586481
PNG
(US11530244, Compound 479)
Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)CCCCCCCCCCNC(=O)[C@@H]1CSCc2cccc(CSCCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C)C(=O)N[C@@H](Cc3c[nH]c4ccc(F)cc34)C(=O)N[C@@H](Cc3c[nH]c4ccc(F)cc34)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3cnc[nH]3)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N3CCC[C@@]3(C)C(=O)N1)c2)C(N)=O)C(O)=O |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586483
PNG
(US11530244, Compound 481 | US11530244, Compound 48...)
Show SMILES C[C@@]12CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1c[nH]c3ccc(F)cc13)NC(=O)[C@H](Cc1c[nH]c3ccc(F)cc13)NC(=O)CNC(=O)[C@@H]1CCC(=O)N1CCCSCc1cccc(CSC[C@H](NC2=O)C(N)=O)c1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586323
PNG
(US11530244, Compound 483)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@@H](C)NC(=O)CCCCSc3c(F)c(F)c(SCCNC(=O)[C@]4(C)CCCN4C2=O)c(F)c3F)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586485
PNG
(US11530244, Compound 484)
Show SMILES COCCOCCOCCOCCC(=O)NCCCC[C@@H]1NC(=O)CCSCc2cccc(CSC[C@H](NC(=O)[C@]3(C)CCCN3C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](Cc3c[nH+]c[nH]3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)CNC1=O)C(N)=O)c2 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM50554752
PNG
(CHEMBL4743663 | US11530244, Compound 485)
Show SMILES C[C@@]12CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1c[nH]c3ccc(F)cc13)NC(=O)[C@H](Cc1c[nH]c3ccc(F)cc13)NC(=O)CNC(=O)[C@H](CCCCNC(=O)CCOCCOCCOCCOCCN)NC(=O)CCSCc1cccc(CSC[C@H](NC2=O)C(N)=O)c1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586326
PNG
(US11530244, Compound 495)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCC\C=C/CCCC[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCSCc4cccc(CSCCNC(=O)[C@]5(C)CCCN5C2=O)c4)C(=O)N[C@@H](Cc2c[nH]c4ccc(F)cc24)C(=O)N3)[C@@H](C)O)cc1 |r,c:20|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586331
PNG
(US11530244, Compound 501)
Show SMILES CO[C@H](C)[C@@H]1NC(=O)[C@@H]2CC\C=C/COc3cccc(C[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCSCc4cccc(CSCCNC(=O)[C@]5(C)CCCN5C(=O)[C@H](Cc5ccc(OC)cc5)NC1=O)c4)C(=O)N[C@@H](Cc1c[nH]c4ccc(F)cc14)C(=O)N2C)c3 |r,c:11|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586332
PNG
(US11530244, Compound 503)
Show SMILES CO[C@H](C)[C@@H]1NC(=O)[C@@H]2CC\C=C\COc3cccc(C[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCSCc4cccc(CSCCNC(=O)[C@]5(C)CCCN5C(=O)[C@H](Cc5ccc(OC)cc5)NC1=O)c4)C(=O)N[C@@H](Cc1c[nH]c4ccc(F)cc14)C(=O)N2C)c3 |r,t:11|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586336
PNG
(US11530244, Compound 507)
Show SMILES CO[C@H](C)[C@@H]1NC(=O)[C@@H]2CC\C=C\COc3cccc(C[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCS(=O)Cc4cc(F)cc(CSCCNC(=O)[C@]5(C)CCCN5C(=O)[C@H](Cc5ccc(OC)cc5)NC1=O)c4)C(=O)N[C@@H](Cc1c[nH]c4ccc(F)cc14)C(=O)N2C)c3 |r,t:11|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586338
PNG
(US11530244, Compound 509)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H]3CC\C=C/CO[C@H]4C[C@H](N(C4)C(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCSCc4cccc(CSC[C@H](NC(=O)[C@]5(C)CCCN5C2=O)C(N)=O)c4)C(=O)N3)cc1 |r,c:14|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586340
PNG
(US11530244, Compound 511)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCCCCCCO[C@H]4C[C@H](N(C4)C(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCSCc4cccc(CSC[C@H](NC(=O)[C@]5(C)CCCN5C2=O)C(N)=O)c4)C(=O)N3)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586341
PNG
(US11530244, Compound 512)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCC\C=C/CO[C@H]4C[C@H](N(C4)C(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@@H](C)NC(=O)CCCCCC(=O)NCc4ccc(C[C@H](NC(=O)[C@]5(C)CCCN5C2=O)C(N)=O)cc4)C(=O)N3)cc1 |r,c:15|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586342
PNG
(US11530244, Compound 513)
Show SMILES CO[C@H](C)[C@@H]1NC(=O)[C@@H]2CCC\C=C\c3cccc(C[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCSCc4cccc(CSCCNC(=O)[C@]5(C)CCCN5C(=O)[C@H](Cc5ccc(OC)cc5)NC1=O)c4)C(=O)N[C@@H](Cc1c[nH]c4ccc(F)cc14)C(=O)N2C)c3 |r,t:12|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586344
PNG
(US11530244, Compound 515)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@H](C)NC(=O)[C@@H]3CCCCNc4cc(C[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCSCc5cccc(CSC[C@H](NC(=O)[C@]6(C)CCCN6C2=O)C(N)=O)c5)C(=O)N[C@@H](Cc2c[nH]c5ccc(F)cc25)C(=O)N3)ccn4)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586345
PNG
(US11530244, Compound 516)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3[C@@H]4CCN3C(=O)[C@H](Cc3c[nH]c5ccc(F)cc35)NC(=O)[C@H](Cc3cccc(OC\C=C\CO4)c3)NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCSCc3cccc(CSCCNC(=O)[C@]4(C)CCCN4C2=O)c3)[C@@H](C)O)cc1 |r,t:49|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586347
PNG
(US11530244, Compound 520)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCCCC(=O)N[C@H]4C[C@H](N(C4)C(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@@H](C)NC(=O)[C@H](CCCN=[N+]=[N-])NC(=O)CCSCc4cccc(CCSCNC(=O)[C@]5(C)CCCN5C2=O)c4)C(=O)N3)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586348
PNG
(US11530244, Compound 521)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCCCC(=O)N[C@H]4C[C@H](N(C4)C(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@@H](C)NC(=O)[C@H](CCCN)NC(=O)CCSCc4cccc(CCSCNC(=O)[C@]5(C)CCCN5C2=O)c4)C(=O)N3)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586487
PNG
(US11530244, Compound 522)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCCC(=O)N[C@@H]4C[C@@H](N(C4)C(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCSCc4cccc(CSCCNC(=O)[C@]5(C)CCCN5C2=O)c4)C(=O)N3)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586490
PNG
(US11530244, Compound 526)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCc4cn(CCCC[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCSCc5cccc(CSCCNC(=O)[C@]6(C)CCCN6C2=O)c5)C(=O)N[C@@H](Cc2c[nH]c5ccc(F)cc25)C(=O)N3)nn4)[C@H](C)O)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Standard assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent A (KD=83 nM). A s...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586117
PNG
(US11530244, Compound 034)
Show SMILES CO[C@H](C)[C@@H]1NC(=O)CCSCc2cccc(CSC[C@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccc(OC)cc3)NC(=O)[C@H](Cc3ccc(OC)cc3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3ccc(OC)cc3)NC(=O)[C@H](Cc3ccc(OC)cc3)NC(=O)[C@@H](CC(C)C)NC1=O)C(N)=O)c2 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Plus assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent B (KD=35 nM). A solut...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586118
PNG
(US11530244, Compound 035)
Show SMILES CO[C@H](C)[C@@H]1NC(=O)CCSCc2cccc(CSC[C@H](NC(=O)[C@]3(C)CCCN3C(=O)[C@H](Cc3ccc(OC)cc3)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](Cc3ccc(OC)cc3)NC(=O)[C@H](Cc3ccc(OC)cc3)NC(=O)[C@@H](CC(C)C)NC1=O)[C@@H](C)OC)C(N)=O)c2 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Plus assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent B (KD=35 nM). A solut...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586364
PNG
(US11530244, Compound 089)
Show SMILES C[C@H]1NC(=O)[C@H](CCCCN)NC(=O)CCSCc2cccc(CSC[C@H](NC(=O)[C@]3(C)CCCN3C(=O)[C@H](Cc3ccc(O)cc3)NC(=O)c3cccc(CNC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC1=O)c3)C(N)=O)c2 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Plus assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent B (KD=35 nM). A solut...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586367
PNG
(US11530244, Compound 092)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](F)CN3C(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@H](Cc3c[nH]c4ccc(F)cc34)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)CCCNC(=O)COc3ccc(C[C@H](NC(=O)[C@]4(C)CCCN4C2=O)C(N)=O)cc3)[C@@H](C)O)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
The PCSK9 Alexa FRET Plus assay measured the interaction between PCSK9 and an AlexaFluor647 (AF) tagged cyclic peptide, Reagent B (KD=35 nM). A solut...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586345
PNG
(US11530244, Compound 516)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3[C@@H]4CCN3C(=O)[C@H](Cc3c[nH]c5ccc(F)cc35)NC(=O)[C@H](Cc3cccc(OC\C=C\CO4)c3)NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCSCc3cccc(CSCCNC(=O)[C@]4(C)CCCN4C2=O)c3)[C@@H](C)O)cc1 |r,t:49|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586347
PNG
(US11530244, Compound 520)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCCCC(=O)N[C@H]4C[C@H](N(C4)C(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@@H](C)NC(=O)[C@H](CCCN=[N+]=[N-])NC(=O)CCSCc4cccc(CCSCNC(=O)[C@]5(C)CCCN5C2=O)c4)C(=O)N3)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Proprotein convertase subtilisin/kexin type 9/Low-density lipoprotein receptor


(Homo sapiens (Human))		BDBM586348
PNG
(US11530244, Compound 521)
Show SMILES COc1ccc(C[C@@H]2NC(=O)[C@@H]3CCCCC(=O)N[C@H]4C[C@H](N(C4)C(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@H](Cc4c[nH]c5ccc(F)cc45)NC(=O)[C@@H](C)NC(=O)[C@H](CCCN)NC(=O)CCSCc4cccc(CCSCNC(=O)[C@]5(C)CCCN5C2=O)c4)C(=O)N3)cc1 |r|
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a


TBA

Assay Description
A set of cyclic polypeptides were identified to inhibit the interaction between human PCSK9 and human LDLR. Each polypeptide has an N-terminal amino ...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2SQ9476
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 815 total )  |  Next  |  Last  >>
Jump to: