Found 216 hits with Last Name = 'hyohdoh' and Initial = 'i' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50197690
![PNG](/data/jpeg/tenK5019/BindingDB_50197690.png) (CHEMBL3976548)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50197709
![PNG](/data/jpeg/tenK5019/BindingDB_50197709.png) (CHEMBL3984621)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2cc(CN3CCOCC3)ccc2[nH]1 Show InChI InChI=1S/C23H22ClN5O3/c24-18-3-2-16(30)11-21(18)29-23(25)17(12-26-29)22(31)20-10-15-9-14(1-4-19(15)27-20)13-28-5-7-32-8-6-28/h1-4,9-12,27,30H,5-8,13,25H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.430 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50197709
![PNG](/data/jpeg/tenK5019/BindingDB_50197709.png) (CHEMBL3984621)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2cc(CN3CCOCC3)ccc2[nH]1 Show InChI InChI=1S/C23H22ClN5O3/c24-18-3-2-16(30)11-21(18)29-23(25)17(12-26-29)22(31)20-10-15-9-14(1-4-19(15)27-20)13-28-5-7-32-8-6-28/h1-4,9-12,27,30H,5-8,13,25H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50197685
![PNG](/data/jpeg/tenK5019/BindingDB_50197685.png) (CHEMBL3681278 | US10689705, Compound 1)Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197709
![PNG](/data/jpeg/tenK5019/BindingDB_50197709.png) (CHEMBL3984621)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2cc(CN3CCOCC3)ccc2[nH]1 Show InChI InChI=1S/C23H22ClN5O3/c24-18-3-2-16(30)11-21(18)29-23(25)17(12-26-29)22(31)20-10-15-9-14(1-4-19(15)27-20)13-28-5-7-32-8-6-28/h1-4,9-12,27,30H,5-8,13,25H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human KDR by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50197702
![PNG](/data/jpeg/tenK5019/BindingDB_50197702.png) (CHEMBL3681287)Show SMILES CCc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N Show InChI InChI=1S/C21H18N6O/c1-2-19-25-16-8-7-13(10-17(16)26-19)27-21(22)14(11-23-27)20(28)18-9-12-5-3-4-6-15(12)24-18/h3-11,24H,2,22H2,1H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50197691
![PNG](/data/jpeg/tenK5019/BindingDB_50197691.png) (CHEMBL3891894)Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)c1N Show InChI InChI=1S/C25H25N7O2/c1-15-28-21-5-3-18(12-22(21)29-15)32-25(26)19(13-27-32)24(33)23-11-17-10-16(2-4-20(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM130903
![PNG](/data/jpeg/tenK13/BindingDB_130903.png) (US10689705, Compound 7 | US8829199, 196)Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(F)(F)CC4)cc3[nH]2)c1N Show InChI InChI=1S/C26H25F2N7O/c1-15-31-20-5-4-18(12-22(20)32-15)35-25(29)19(13-30-35)24(36)23-11-17-3-2-16(10-21(17)33-23)14-34-8-6-26(27,28)7-9-34/h2-5,10-13,33H,6-9,14,29H2,1H3,(H,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50197685
![PNG](/data/jpeg/tenK5019/BindingDB_50197685.png) (CHEMBL3681278 | US10689705, Compound 1)Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197685
![PNG](/data/jpeg/tenK5019/BindingDB_50197685.png) (CHEMBL3681278 | US10689705, Compound 1)Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50197709
![PNG](/data/jpeg/tenK5019/BindingDB_50197709.png) (CHEMBL3984621)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2cc(CN3CCOCC3)ccc2[nH]1 Show InChI InChI=1S/C23H22ClN5O3/c24-18-3-2-16(30)11-21(18)29-23(25)17(12-26-29)22(31)20-10-15-9-14(1-4-19(15)27-20)13-28-5-7-32-8-6-28/h1-4,9-12,27,30H,5-8,13,25H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197709
![PNG](/data/jpeg/tenK5019/BindingDB_50197709.png) (CHEMBL3984621)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2cc(CN3CCOCC3)ccc2[nH]1 Show InChI InChI=1S/C23H22ClN5O3/c24-18-3-2-16(30)11-21(18)29-23(25)17(12-26-29)22(31)20-10-15-9-14(1-4-19(15)27-20)13-28-5-7-32-8-6-28/h1-4,9-12,27,30H,5-8,13,25H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50197703
![PNG](/data/jpeg/tenK5019/BindingDB_50197703.png) (CHEMBL3981956)Show InChI InChI=1S/C18H12ClN3O3/c19-13-6-5-11(23)8-14(13)22-18(20)12(9-21-22)17(24)16-7-10-3-1-2-4-15(10)25-16/h1-9,23H,20H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50197691
![PNG](/data/jpeg/tenK5019/BindingDB_50197691.png) (CHEMBL3891894)Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)c1N Show InChI InChI=1S/C25H25N7O2/c1-15-28-21-5-3-18(12-22(21)29-15)32-25(26)19(13-27-32)24(33)23-11-17-10-16(2-4-20(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50494481
![PNG](/data/jpeg/tenK5049/BindingDB_50494481.png) (CHEMBL3092178)Show SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(I)c(OC(=O)N(C)C)cc3oc2=O)c1 Show InChI InChI=1S/C21H22IN3O6S/c1-12-15-10-17(22)19(31-21(27)25(3)4)11-18(15)30-20(26)16(12)9-13-6-5-7-14(8-13)24-32(28,29)23-2/h5-8,10-11,23-24H,9H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 m... |
ACS Med Chem Lett 4: 1059-63 (2013)
Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197691
![PNG](/data/jpeg/tenK5019/BindingDB_50197691.png) (CHEMBL3891894)Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)c1N Show InChI InChI=1S/C25H25N7O2/c1-15-28-21-5-3-18(12-22(21)29-15)32-25(26)19(13-27-32)24(33)23-11-17-10-16(2-4-20(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197710
![PNG](/data/jpeg/tenK5019/BindingDB_50197710.png) (CHEMBL3959997)Show SMILES Cc1cc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N Show InChI InChI=1S/C21H17N5O/c1-12-8-14-9-15(6-7-18(14)24-12)26-21(22)16(11-23-26)20(27)19-10-13-4-2-3-5-17(13)25-19/h2-11,24-25H,22H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human KDR by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50443366
![PNG](/data/jpeg/tenK5044/BindingDB_50443366.png) (CHEMBL3086065)Show SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1 Show InChI InChI=1S/C21H22ClN3O6S/c1-12-15-10-17(22)19(31-21(27)25(3)4)11-18(15)30-20(26)16(12)9-13-6-5-7-14(8-13)24-32(28,29)23-2/h5-8,10-11,23-24H,9H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 m... |
ACS Med Chem Lett 4: 1059-63 (2013)
Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197683
![PNG](/data/jpeg/tenK5019/BindingDB_50197683.png) (CHEMBL3907479 | US10689705, Compound 49)Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N Show InChI InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50494482
![PNG](/data/jpeg/tenK5049/BindingDB_50494482.png) (CHEMBL3092191)Show SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(OC(=O)N(C)C)cc3oc2=O)c1F Show InChI InChI=1S/C21H22FN3O6S/c1-12-15-9-8-14(30-21(27)25(3)4)11-18(15)31-20(26)16(12)10-13-6-5-7-17(19(13)22)24-32(28,29)23-2/h5-9,11,23-24H,10H2,1-4H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assay |
ACS Med Chem Lett 4: 1059-63 (2013)
Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50443366
![PNG](/data/jpeg/tenK5044/BindingDB_50443366.png) (CHEMBL3086065)Show SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(Cl)c(OC(=O)N(C)C)cc3oc2=O)c1 Show InChI InChI=1S/C21H22ClN3O6S/c1-12-15-10-17(22)19(31-21(27)25(3)4)11-18(15)30-20(26)16(12)9-13-6-5-7-14(8-13)24-32(28,29)23-2/h5-8,10-11,23-24H,9H2,1-4H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assay |
ACS Med Chem Lett 4: 1059-63 (2013)
Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50197683
![PNG](/data/jpeg/tenK5019/BindingDB_50197683.png) (CHEMBL3907479 | US10689705, Compound 49)Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N Show InChI InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM130903
![PNG](/data/jpeg/tenK13/BindingDB_130903.png) (US10689705, Compound 7 | US8829199, 196)Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCC(F)(F)CC4)cc3[nH]2)c1N Show InChI InChI=1S/C26H25F2N7O/c1-15-31-20-5-4-18(12-22(20)32-15)35-25(29)19(13-30-35)24(36)23-11-17-3-2-16(10-21(17)33-23)14-34-8-6-26(27,28)7-9-34/h2-5,10-13,33H,6-9,14,29H2,1H3,(H,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197692
![PNG](/data/jpeg/tenK5019/BindingDB_50197692.png) (CHEMBL3895337)Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccc(C)cc3[nH]2)c1N Show InChI InChI=1S/C21H18N6O/c1-11-3-4-13-8-19(26-17(13)7-11)20(28)15-10-23-27(21(15)22)14-5-6-16-18(9-14)25-12(2)24-16/h3-10,26H,22H2,1-2H3,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50197686
![PNG](/data/jpeg/tenK5019/BindingDB_50197686.png) (CHEMBL3956001)Show InChI InChI=1S/C18H13ClN4O/c19-13-6-2-4-8-16(13)23-18(20)12(10-21-23)17(24)15-9-11-5-1-3-7-14(11)22-15/h1-10,22H,20H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM50197685
![PNG](/data/jpeg/tenK5019/BindingDB_50197685.png) (CHEMBL3681278 | US10689705, Compound 1)Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(CN4CCOCC4)cc3[nH]2)c1N Show InChI InChI=1S/C25H25N7O2/c1-15-28-20-5-4-18(12-22(20)29-15)32-25(26)19(13-27-32)24(33)23-11-17-3-2-16(10-21(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR4 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50494494
![PNG](/data/jpeg/tenK5049/BindingDB_50494494.png) (CHEMBL3092185)Show SMILES CN(C)C(=O)Oc1ccc2c(C)c(Cc3cccc(NS(N)(=O)=O)c3F)c(=O)oc2c1 Show InChI InChI=1S/C20H20FN3O6S/c1-11-14-8-7-13(29-20(26)24(2)3)10-17(14)30-19(25)15(11)9-12-5-4-6-16(18(12)21)23-31(22,27)28/h4-8,10,23H,9H2,1-3H3,(H2,22,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assay |
ACS Med Chem Lett 4: 1059-63 (2013)
Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50197710
![PNG](/data/jpeg/tenK5019/BindingDB_50197710.png) (CHEMBL3959997)Show SMILES Cc1cc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N Show InChI InChI=1S/C21H17N5O/c1-12-8-14-9-15(6-7-18(14)24-12)26-21(22)16(11-23-26)20(27)19-10-13-4-2-3-5-17(13)25-19/h2-11,24-25H,22H2,1H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50197692
![PNG](/data/jpeg/tenK5019/BindingDB_50197692.png) (CHEMBL3895337)Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccc(C)cc3[nH]2)c1N Show InChI InChI=1S/C21H18N6O/c1-11-3-4-13-8-19(26-17(13)7-11)20(28)15-10-23-27(21(15)22)14-5-6-16-18(9-14)25-12(2)24-16/h3-10,26H,22H2,1-2H3,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197712
![PNG](/data/jpeg/tenK5019/BindingDB_50197712.png) (CHEMBL3676329 | US10689705, Compound 44)Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(Br)cc3[nH]2)c1N Show InChI InChI=1S/C20H15BrN6O/c1-10-24-15-5-4-13(8-17(15)25-10)27-20(22)14(9-23-27)19(28)18-6-11-2-3-12(21)7-16(11)26-18/h2-9,26H,22H2,1H3,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM130906
![PNG](/data/jpeg/tenK13/BindingDB_130906.png) (US10689705, Compound 46 | US8829199, 200)Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)S(C)(=O)=O)c1N Show InChI InChI=1S/C21H18N6O3S/c1-11-24-16-6-4-13(8-18(16)25-11)27-21(22)15(10-23-27)20(28)19-7-12-3-5-14(31(2,29)30)9-17(12)26-19/h3-10,26H,22H2,1-2H3,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50010471
![PNG](/data/jpeg/tenK5001/BindingDB_50010471.png) (CHEMBL3263999)Show SMILES CNS(=O)(=O)Nc1nccc(Cc2c(C)c3ccc(Oc4ccccc4)cc3oc2=O)c1F Show InChI InChI=1S/C23H20FN3O5S/c1-14-18-9-8-17(31-16-6-4-3-5-7-16)13-20(18)32-23(28)19(14)12-15-10-11-26-22(21(15)24)27-33(29,30)25-2/h3-11,13,25H,12H2,1-2H3,(H,26,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 mins |
ACS Med Chem Lett 5: 309-14 (2014)
Article DOI: 10.1021/ml400379x BindingDB Entry DOI: 10.7270/Q27W6DQD |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50197683
![PNG](/data/jpeg/tenK5019/BindingDB_50197683.png) (CHEMBL3907479 | US10689705, Compound 49)Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N Show InChI InChI=1S/C20H16N6O/c1-11-23-16-7-6-13(9-17(16)24-11)26-20(21)14(10-22-26)19(27)18-8-12-4-2-3-5-15(12)25-18/h2-10,25H,21H2,1H3,(H,23,24) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50010463
![PNG](/data/jpeg/tenK5001/BindingDB_50010463.png) (CHEMBL3092195)Show SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F Show InChI InChI=1S/C22H19FN4O5S/c1-13-16-8-7-15(31-22-25-9-4-10-26-22)12-19(16)32-21(28)17(13)11-14-5-3-6-18(20(14)23)27-33(29,30)24-2/h3-10,12,24,27H,11H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assay |
ACS Med Chem Lett 4: 1059-63 (2013)
Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50010463
![PNG](/data/jpeg/tenK5001/BindingDB_50010463.png) (CHEMBL3092195)Show SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(Oc4ncccn4)cc3oc2=O)c1F Show InChI InChI=1S/C22H19FN4O5S/c1-13-16-8-7-15(31-22-25-9-4-10-26-22)12-19(16)32-21(28)17(13)11-14-5-3-6-18(20(14)23)27-33(29,30)24-2/h3-10,12,24,27H,11H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 mins |
ACS Med Chem Lett 5: 309-14 (2014)
Article DOI: 10.1021/ml400379x BindingDB Entry DOI: 10.7270/Q27W6DQD |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50197690
![PNG](/data/jpeg/tenK5019/BindingDB_50197690.png) (CHEMBL3976548)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR3 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50494481
![PNG](/data/jpeg/tenK5049/BindingDB_50494481.png) (CHEMBL3092178)Show SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(I)c(OC(=O)N(C)C)cc3oc2=O)c1 Show InChI InChI=1S/C21H22IN3O6S/c1-12-15-10-17(22)19(31-21(27)25(3)4)11-18(15)30-20(26)16(12)9-13-6-5-7-14(8-13)24-32(28,29)23-2/h5-8,10-11,23-24H,9H2,1-4H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of C-Raf (unknown origin) assessed as phosphorylation of MEK1 after 45 mins by TR-FRET assay |
ACS Med Chem Lett 4: 1059-63 (2013)
Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 4
(Homo sapiens (Human)) | BDBM50197691
![PNG](/data/jpeg/tenK5019/BindingDB_50197691.png) (CHEMBL3891894)Show SMILES Cc1nc2ccc(cc2[nH]1)-n1ncc(C(=O)c2cc3cc(CN4CCOCC4)ccc3[nH]2)c1N Show InChI InChI=1S/C25H25N7O2/c1-15-28-21-5-3-18(12-22(21)29-15)32-25(26)19(13-27-32)24(33)23-11-17-10-16(2-4-20(17)30-23)14-31-6-8-34-9-7-31/h2-5,10-13,30H,6-9,14,26H2,1H3,(H,28,29) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR4 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50494484
![PNG](/data/jpeg/tenK5049/BindingDB_50494484.png) (CHEMBL3092176)Show SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(Oc4nccs4)cc3oc2=O)c1F Show InChI InChI=1S/C21H18FN3O5S2/c1-12-15-7-6-14(29-21-24-8-9-31-21)11-18(15)30-20(26)16(12)10-13-4-3-5-17(19(13)22)25-32(27,28)23-2/h3-9,11,23,25H,10H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 m... |
ACS Med Chem Lett 4: 1059-63 (2013)
Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197690
![PNG](/data/jpeg/tenK5019/BindingDB_50197690.png) (CHEMBL3976548)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human KDR by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50010469
![PNG](/data/jpeg/tenK5001/BindingDB_50010469.png) (CHEMBL3092179)Show SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3cc(C)c(OC(=O)N(C)C)cc3oc2=O)c1 Show InChI InChI=1S/C22H25N3O6S/c1-13-9-17-14(2)18(11-15-7-6-8-16(10-15)24-32(28,29)23-3)21(26)30-20(17)12-19(13)31-22(27)25(4)5/h6-10,12,23-24H,11H2,1-5H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 m... |
ACS Med Chem Lett 4: 1059-63 (2013)
Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197690
![PNG](/data/jpeg/tenK5019/BindingDB_50197690.png) (CHEMBL3976548)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C18H13ClN4O2/c19-13-6-5-11(24)8-16(13)23-18(20)12(9-21-23)17(25)15-7-10-3-1-2-4-14(10)22-15/h1-9,22,24H,20H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50197713
![PNG](/data/jpeg/tenK5019/BindingDB_50197713.png) (CHEMBL3947281)Show SMILES Nc1c(cnn1-c1cc(O)ccc1Cl)C(=O)c1ccc2ncccc2c1 Show InChI InChI=1S/C19H13ClN4O2/c20-15-5-4-13(25)9-17(15)24-19(21)14(10-23-24)18(26)12-3-6-16-11(8-12)2-1-7-22-16/h1-10,25H,21H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human SRC by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
RAF proto-oncogene serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50010465
![PNG](/data/jpeg/tenK5001/BindingDB_50010465.png) (CHEMBL3263996)Show SMILES CNS(=O)(=O)Nc1cc(Cc2c(C)c3ccc(OC(=O)N(C)C)cc3oc2=O)ccn1 Show InChI InChI=1S/C20H22N4O6S/c1-12-15-6-5-14(29-20(26)24(3)4)11-17(15)30-19(25)16(12)9-13-7-8-22-18(10-13)23-31(27,28)21-2/h5-8,10-11,21H,9H2,1-4H3,(H,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 mins |
ACS Med Chem Lett 5: 309-14 (2014)
Article DOI: 10.1021/ml400379x BindingDB Entry DOI: 10.7270/Q27W6DQD |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197710
![PNG](/data/jpeg/tenK5019/BindingDB_50197710.png) (CHEMBL3959997)Show SMILES Cc1cc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccccc3[nH]2)c1N Show InChI InChI=1S/C21H17N5O/c1-12-8-14-9-15(6-7-18(14)24-12)26-21(22)16(11-23-26)20(27)19-10-13-4-2-3-5-17(13)25-19/h2-11,24-25H,22H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50197689
![PNG](/data/jpeg/tenK5019/BindingDB_50197689.png) (CHEMBL3934547)Show SMILES Nc1c(cnn1-c1ccc2nc[nH]c2c1)C(=O)c1cc2ccccc2[nH]1 Show InChI InChI=1S/C19H14N6O/c20-19-13(18(26)17-7-11-3-1-2-4-14(11)24-17)9-23-25(19)12-5-6-15-16(8-12)22-10-21-15/h1-10,24H,20H2,(H,21,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50494482
![PNG](/data/jpeg/tenK5049/BindingDB_50494482.png) (CHEMBL3092191)Show SMILES CNS(=O)(=O)Nc1cccc(Cc2c(C)c3ccc(OC(=O)N(C)C)cc3oc2=O)c1F Show InChI InChI=1S/C21H22FN3O6S/c1-12-15-9-8-14(30-21(27)25(3)4)11-18(15)31-20(26)16(12)10-13-6-5-7-17(19(13)22)24-32(28,29)23-2/h5-9,11,23-24H,10H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 m... |
ACS Med Chem Lett 4: 1059-63 (2013)
Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50197687
![PNG](/data/jpeg/tenK5019/BindingDB_50197687.png) (CHEMBL3681244 | US10689705, Compound 34)Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(cc3[nH]2)-c2ccccc2)c1N Show InChI InChI=1S/C26H20N6O/c1-15-29-21-10-9-19(13-23(21)30-15)32-26(27)20(14-28-32)25(33)24-12-18-8-7-17(11-22(18)31-24)16-5-3-2-4-6-16/h2-14,31H,27H2,1H3,(H,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR2 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50494485
![PNG](/data/jpeg/tenK5049/BindingDB_50494485.png) (CHEMBL3092184)Show SMILES CN(C)C(=O)Oc1ccc2c(C)c(Cc3ccc(F)c(NS(N)(=O)=O)c3)c(=O)oc2c1 Show InChI InChI=1S/C20H20FN3O6S/c1-11-14-6-5-13(29-20(26)24(2)3)10-18(14)30-19(25)15(11)8-12-4-7-16(21)17(9-12)23-31(22,27)28/h4-7,9-10,23H,8H2,1-3H3,(H2,22,27,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co. Ltd
Curated by ChEMBL
| Assay Description Inhibition of MEK1 (unknown origin) assessed as phosphorylation of Erk2 preincubated for 30 mins followed by FAM-Erktide addition measured after 60 m... |
ACS Med Chem Lett 4: 1059-63 (2013)
Article DOI: 10.1021/ml4002419 BindingDB Entry DOI: 10.7270/Q20K2CJZ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50197712
![PNG](/data/jpeg/tenK5019/BindingDB_50197712.png) (CHEMBL3676329 | US10689705, Compound 44)Show SMILES Cc1nc2cc(ccc2[nH]1)-n1ncc(C(=O)c2cc3ccc(Br)cc3[nH]2)c1N Show InChI InChI=1S/C20H15BrN6O/c1-10-24-15-5-4-13(8-17(15)25-10)27-20(22)14(9-23-27)19(28)18-6-11-2-3-12(21)7-16(11)26-18/h2-9,26H,22H2,1H3,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd.
Curated by ChEMBL
| Assay Description Inhibition of human FGFR1 by time-resolved fluorescence or time-resolved fluorescence assay |
J Med Chem 59: 10586-10600 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01156 BindingDB Entry DOI: 10.7270/Q2ZS2ZGV |
More data for this Ligand-Target Pair | |