Found 597 hits with Last Name = 'shin' and Initial = 'i' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50085048
![PNG](/data/jpeg/tenK5008/BindingDB_50085048.png) ((S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyri...)Show SMILES CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1ccccn1 Show InChI InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 0.430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to PPARgamma (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028 BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human)) | BDBM28661
![PNG](/data/jpeg/tenK2/BindingDB_28661.png) (2-{2-methyl-4-[({4-methyl-2-[4-(trifluoromethyl)ph...)Show SMILES Cc1nc(sc1CSc1ccc(OCC(O)=O)c(C)c1)-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL DrugBank MCE PC cid PC sid PDB UniChem
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Similars
| PDB Article PubMed
| 0.820 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to PPARdelta (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028 BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human)) | BDBM50099491
![PNG](/data/jpeg/tenK5009/BindingDB_50099491.png) (2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)Show SMILES CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O Show InChI InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL MCE KEGG PC cid PC sid PDB UniChem
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Similars
| PDB Article PubMed
| 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to PPARalpha (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028 BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50103521
![PNG](/data/jpeg/tenK5010/BindingDB_50103521.png) (Actos | CHEBI:8228 | Duetact | Pioglitazone | US10...)Show InChI InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Similars
| DrugBank PDB Article PubMed
| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to PPARgamma (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028 BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human)) | BDBM50546080
![PNG](/data/jpeg/tenK5054/BindingDB_50546080.png) (CHEMBL4746218)Show SMILES Oc1cc(O)c2c(oc(cc2=O)-c2ccccc2)c1C(C=C)c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| 960 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to PPARalpha (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028 BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human)) | BDBM50546080
![PNG](/data/jpeg/tenK5054/BindingDB_50546080.png) (CHEMBL4746218)Show SMILES Oc1cc(O)c2c(oc(cc2=O)-c2ccccc2)c1C(C=C)c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| 1.18E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to PPARdelta (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028 BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50546080
![PNG](/data/jpeg/tenK5054/BindingDB_50546080.png) (CHEMBL4746218)Show SMILES Oc1cc(O)c2c(oc(cc2=O)-c2ccccc2)c1C(C=C)c1ccccc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| 1.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to PPARgamma (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028 BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human)) | BDBM50546079
![PNG](/data/jpeg/tenK5054/BindingDB_50546079.png) (CHEMBL4746258)Show SMILES COc1cc(ccc1O)C(C=C)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| 2.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to PPARalpha (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028 BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor delta
(Homo sapiens (Human)) | BDBM50546079
![PNG](/data/jpeg/tenK5054/BindingDB_50546079.png) (CHEMBL4746258)Show SMILES COc1cc(ccc1O)C(C=C)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| 2.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to PPARdelta (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028 BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor gamma
(Homo sapiens (Human)) | BDBM50546079
![PNG](/data/jpeg/tenK5054/BindingDB_50546079.png) (CHEMBL4746258)Show SMILES COc1cc(ccc1O)C(C=C)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| 2.53E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to PPARgamma (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028 BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this Ligand-Target Pair | |
Peroxisome proliferator-activated receptor alpha
(Homo sapiens (Human)) | BDBM24566
![PNG](/data/jpeg/tenK2/BindingDB_24566.png) (2-({4-chloro-6-[(2,3-dimethylphenyl)amino]pyrimidi...)Show InChI InChI=1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| 4.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to PPARalpha (unknown origin) by TR-FRET assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2019.05.028 BindingDB Entry DOI: 10.7270/Q2930XSX |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Epidermal growth factor receptor [1-18,20-1210]
(Homo sapiens (Human)) | BDBM538119
![PNG](/data/jpeg/tenK53/BindingDB_538119.png) (US11253516, Example 21)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCC(CC1)N1CCNCC1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM538108
![PNG](/data/jpeg/tenK53/BindingDB_538108.png) (US11253516, Example 10)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCC(CC1)N1CCN(C)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM538135
![PNG](/data/jpeg/tenK53/BindingDB_538135.png) (US11253516, Example 37)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(N)(=O)=O)n1)N1CCC(CC1)N1CCN(C)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210]
(Homo sapiens (Human)) | BDBM538123
![PNG](/data/jpeg/tenK53/BindingDB_538123.png) (US11253516, Example 25)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCN(CC1)C1CCN(C)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM538139
![PNG](/data/jpeg/tenK53/BindingDB_538139.png) (US11253516, Example 41)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCC(CC1)NCCO | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM538137
![PNG](/data/jpeg/tenK53/BindingDB_538137.png) (US11253516, Example 39)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCC(CC1)NC(C)=O | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM538140
![PNG](/data/jpeg/tenK53/BindingDB_538140.png) (US11253516, Example 42)Show SMILES COCCNC1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3ccccc3NS(C)(=O)=O)n2)c(OC)c1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM538134
![PNG](/data/jpeg/tenK53/BindingDB_538134.png) (US11253516, Example 36)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(N)(=O)=O)n1)N1CCC(CC1)N(C)C | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210]
(Homo sapiens (Human)) | BDBM538125
![PNG](/data/jpeg/tenK53/BindingDB_538125.png) (US11253516, Example 27)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCN(CC1)C1CCNCC1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM538138
![PNG](/data/jpeg/tenK53/BindingDB_538138.png) (US11253516, Example 40)Show SMILES CNC1CCN(CC1)c1ccc(Nc2ncc(Cl)c(Nc3ccccc3NS(C)(=O)=O)n2)c(OC)c1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210]
(Homo sapiens (Human)) | BDBM538120
![PNG](/data/jpeg/tenK53/BindingDB_538120.png) (US11253516, Example 22)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCC(CC1)N1CCN(CCO)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50596834
![PNG](/data/jpeg/tenK5059/BindingDB_50596834.png) (CHEMBL5181852)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(c3)C3CCNCC3)n2)c1Cl | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50355393
![PNG](/data/jpeg/tenK5035/BindingDB_50355393.png) (BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1 Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | <0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50596830
![PNG](/data/jpeg/tenK5059/BindingDB_50596830.png) (CHEMBL5179166)Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncnc(n2)-c2cccnc2Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50596831
![PNG](/data/jpeg/tenK5059/BindingDB_50596831.png) (CHEMBL5177100)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n2)c1Cl |r| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50596832
![PNG](/data/jpeg/tenK5059/BindingDB_50596832.png) (CHEMBL5198569)Show SMILES CCN1CCN(CC1)c1cccc(Nc2ncnc(n2)-c2cccnc2Nc2c(Cl)c(OC)cc(OC)c2Cl)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50596833
![PNG](/data/jpeg/tenK5059/BindingDB_50596833.png) (CHEMBL5193966)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(c3)C3CCN(CC3)C(C)C)n2)c1Cl | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 1
(Homo sapiens (Human)) | BDBM50596834
![PNG](/data/jpeg/tenK5059/BindingDB_50596834.png) (CHEMBL5181852)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(c3)C3CCNCC3)n2)c1Cl | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50355393
![PNG](/data/jpeg/tenK5035/BindingDB_50355393.png) (BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1 Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50596830
![PNG](/data/jpeg/tenK5059/BindingDB_50596830.png) (CHEMBL5179166)Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncnc(n2)-c2cccnc2Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50525939
![PNG](/data/jpeg/tenK5052/BindingDB_50525939.png) (Balversa | Erdafitinib | Jnj-42756493)Show SMILES COc1cc(OC)cc(c1)N(CCNC(C)C)c1ccc2ncc(nc2c1)-c1cnn(C)c1 Show InChI InChI=1S/C25H30N6O2/c1-17(2)26-8-9-31(20-10-21(32-4)13-22(11-20)33-5)19-6-7-23-24(12-19)29-25(15-27-23)18-14-28-30(3)16-18/h6-7,10-17,26H,8-9H2,1-5H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM301310
![PNG](/data/jpeg/tenK30/BindingDB_301310.png) (3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(mo...)Show SMILES CCN1C(=O)N(Cc2cnc3[nH]c(CN4CCOCC4)cc3c12)c1c(F)c(OC)cc(OC)c1F Show InChI InChI=1S/C24H27F2N5O4/c1-4-30-21-14(11-27-23-16(21)9-15(28-23)13-29-5-7-35-8-6-29)12-31(24(30)32)22-19(25)17(33-2)10-18(34-3)20(22)26/h9-11H,4-8,12-13H2,1-3H3,(H,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50596831
![PNG](/data/jpeg/tenK5059/BindingDB_50596831.png) (CHEMBL5177100)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n2)c1Cl |r| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50596832
![PNG](/data/jpeg/tenK5059/BindingDB_50596832.png) (CHEMBL5198569)Show SMILES CCN1CCN(CC1)c1cccc(Nc2ncnc(n2)-c2cccnc2Nc2c(Cl)c(OC)cc(OC)c2Cl)c1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50596833
![PNG](/data/jpeg/tenK5059/BindingDB_50596833.png) (CHEMBL5193966)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(c3)C3CCN(CC3)C(C)C)n2)c1Cl | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50596834
![PNG](/data/jpeg/tenK5059/BindingDB_50596834.png) (CHEMBL5181852)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(c3)C3CCNCC3)n2)c1Cl | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50596833
![PNG](/data/jpeg/tenK5059/BindingDB_50596833.png) (CHEMBL5193966)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(c3)C3CCN(CC3)C(C)C)n2)c1Cl | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50596833
![PNG](/data/jpeg/tenK5059/BindingDB_50596833.png) (CHEMBL5193966)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(c3)C3CCN(CC3)C(C)C)n2)c1Cl | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50596832
![PNG](/data/jpeg/tenK5059/BindingDB_50596832.png) (CHEMBL5198569)Show SMILES CCN1CCN(CC1)c1cccc(Nc2ncnc(n2)-c2cccnc2Nc2c(Cl)c(OC)cc(OC)c2Cl)c1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50596831
![PNG](/data/jpeg/tenK5059/BindingDB_50596831.png) (CHEMBL5177100)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n2)c1Cl |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50596830
![PNG](/data/jpeg/tenK5059/BindingDB_50596830.png) (CHEMBL5179166)Show SMILES CCN1CCN(CC1)c1ccc(Nc2ncnc(n2)-c2cccnc2Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor [1-18,20-1210,T790M,C797S]
(Homo sapiens (Human)) | BDBM538136
![PNG](/data/jpeg/tenK53/BindingDB_538136.png) (US11253516, Example 38)Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2NS(C)(=O)=O)n1)N1CCC(N)CC1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
| Assay Description The composition of the assay buffer used in the activity measurement was 50 mM Tris-HCl pH 7.5, 100 mM NaCl, 7.5 mM MgCl2, 3 mM KCl, 0.01% Tween 20, ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2RJ4NNV |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50596852
![PNG](/data/jpeg/tenK5059/BindingDB_50596852.png) (CHEMBL5193739)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(C)c3)n2)c1Cl | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50355393
![PNG](/data/jpeg/tenK5035/BindingDB_50355393.png) (BGJ398 | CHEMBL1834657 | US9434697, BGJ398 | US973...)Show SMILES CCN1CCN(CC1)c1ccc(Nc2cc(ncn2)N(C)C(=O)Nc2c(Cl)c(OC)cc(OC)c2Cl)cc1 Show InChI InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50596833
![PNG](/data/jpeg/tenK5059/BindingDB_50596833.png) (CHEMBL5193966)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3cnn(c3)C3CCN(CC3)C(C)C)n2)c1Cl | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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TBA
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Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Focal adhesion kinase 1
(Homo sapiens (Human)) | BDBM418817
![PNG](/data/jpeg/tenK41/BindingDB_418817.png) (N-methyl-4-({4-[({3- [methyl(methylsulfonyl)amino]...)Show SMILES CNC(=O)c1ccc(Nc2ncc(c(NCc3nccnc3N(C)S(C)(=O)=O)n2)C(F)(F)F)cc1 Show InChI InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
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TBA
| Assay Description Inhibition of recombinant FAK (unknown origin) by radiometric kinase assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00459 BindingDB Entry DOI: 10.7270/Q2TT4VSH |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 2
(Homo sapiens (Human)) | BDBM50596831
![PNG](/data/jpeg/tenK5059/BindingDB_50596831.png) (CHEMBL5177100)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n2)c1Cl |r| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
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| Article PubMed
| n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50596832
![PNG](/data/jpeg/tenK5059/BindingDB_50596832.png) (CHEMBL5198569)Show SMILES CCN1CCN(CC1)c1cccc(Nc2ncnc(n2)-c2cccnc2Nc2c(Cl)c(OC)cc(OC)c2Cl)c1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |
Fibroblast growth factor receptor 3
(Homo sapiens (Human)) | BDBM50596831
![PNG](/data/jpeg/tenK5059/BindingDB_50596831.png) (CHEMBL5177100)Show SMILES COc1cc(OC)c(Cl)c(Nc2ncccc2-c2ncnc(Nc3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)n2)c1Cl |r| | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01776 BindingDB Entry DOI: 10.7270/Q2765KCQ |
More data for this Ligand-Target Pair | |