Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human)) | BDBM525281 (US11173137, Compound AK3-101A | US11173137, Compou...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alpha-2A adrenergic receptor (Homo sapiens (Human)) | BDBM525279 (US11173137, Compound FA26 | US11173137, Compound ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M4 (Homo sapiens (Human)) | BDBM525281 (US11173137, Compound AK3-101A | US11173137, Compou...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human)) | BDBM525279 (US11173137, Compound FA26 | US11173137, Compound ...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human)) | BDBM525279 (US11173137, Compound FA26 | US11173137, Compound ...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 8 (Homo sapiens (Human)) | BDBM525279 (US11173137, Compound FA26 | US11173137, Compound ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM525279 (US11173137, Compound FA26 | US11173137, Compound ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 1 (Homo sapiens (Human)) | BDBM525281 (US11173137, Compound AK3-101A | US11173137, Compou...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 2 (Homo sapiens (Human)) | BDBM525279 (US11173137, Compound FA26 | US11173137, Compound ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 4 (Homo sapiens (Human)) | BDBM525279 (US11173137, Compound FA26 | US11173137, Compound ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM525279 (US11173137, Compound FA26 | US11173137, Compound ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM525281 (US11173137, Compound AK3-101A | US11173137, Compou...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 6 (Homo sapiens (Human)) | BDBM525279 (US11173137, Compound FA26 | US11173137, Compound ...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human)) | BDBM525279 (US11173137, Compound FA26 | US11173137, Compound ...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM525279 (US11173137, Compound FA26 | US11173137, Compound ...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM525281 (US11173137, Compound AK3-101A | US11173137, Compou...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Muscarinic acetylcholine receptor M5 (Homo sapiens (Human)) | BDBM525281 (US11173137, Compound AK3-101A | US11173137, Compou...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Two exemplary compounds, FA44 and FA26, were screened against a panel of CNS receptors, transporters, and ion channels to examine specificity for CLC... | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 7 subunit alpha (Homo sapiens (Human)) | BDBM50451447 (CHEMBL4217988) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Mus musculus) | BDBM50451447 (CHEMBL4217988) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | <0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 7 subunit alpha (Homo sapiens (Human)) | BDBM145285 (US8952169, 64 | US9771376, Example 64) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 7 subunit alpha (Homo sapiens (Human)) | BDBM145591 (US8952169, 389) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 7 subunit alpha (Homo sapiens (Human)) | BDBM50051073 (CHEMBL3318132) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 7 subunit alpha (Homo sapiens (Human)) | BDBM50505258 (CHEMBL4588728) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM190233 (US9174999, Table 1, Compound 1) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM190233 (US9174999, Table 1, Compound 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Rattus norvegicus) | BDBM50505258 (CHEMBL4588728) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of rat Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 4 subunit alpha (Homo sapiens (Human)) | BDBM190233 (US9174999, Table 1, Compound 1) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00378 BindingDB Entry DOI: 10.7270/Q2SF3151 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50595862 (CHEMBL5189924) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00378 BindingDB Entry DOI: 10.7270/Q2SF3151 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 4 subunit alpha (Homo sapiens (Human)) | BDBM50595859 (CHEMBL5192731) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00378 BindingDB Entry DOI: 10.7270/Q2SF3151 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 4 subunit alpha (Homo sapiens (Human)) | BDBM50595862 (CHEMBL5189924) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00378 BindingDB Entry DOI: 10.7270/Q2SF3151 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM145591 (US8952169, 389) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Chloride channel protein 2 (Human) | BDBM525281 (US11173137, Compound AK3-101A | US11173137, Compou...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description CLC-2 activity using cell-free assays, e.g., binding assays; with purified enzymes. | Citation and Details BindingDB Entry DOI: 10.7270/Q2HX1GVZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 7 subunit alpha (Homo sapiens (Human)) | BDBM50077471 (CHEMBL3416886) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Mus musculus) | BDBM145591 (US8952169, 389) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM50344821 (10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM190233 (US9174999, Table 1, Compound 1) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 4 subunit alpha (Rattus norvegicus (Rat)) | BDBM190233 (US9174999, Table 1, Compound 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
The Board of Trustees of the Leland Stanford Junior University US Patent | Assay Description In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n... | US Patent US9174999 (2015) BindingDB Entry DOI: 10.7270/Q2C24V68 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 2 subunit alpha (Homo sapiens (Human)) | BDBM50451447 (CHEMBL4217988) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50595859 (CHEMBL5192731) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00378 BindingDB Entry DOI: 10.7270/Q2SF3151 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 7 subunit alpha (Homo sapiens (Human)) | BDBM217483 (US9212182, 477 | US9212182, 478) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 7 subunit alpha (Homo sapiens (Human)) | BDBM217483 (US9212182, 477 | US9212182, 478) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Rattus norvegicus) | BDBM145591 (US8952169, 389) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of rat Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM50344821 (10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Mus musculus) | BDBM50505258 (CHEMBL4588728) | PDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 3 subunit alpha (Homo sapiens (Human)) | BDBM50344821 (10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human)) | BDBM50451447 (CHEMBL4217988) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50595863 (CHEMBL5184022) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00378 BindingDB Entry DOI: 10.7270/Q2SF3151 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 1 subunit alpha (Homo sapiens (Human)) | BDBM145591 (US8952169, 389) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM50595864 (CHEMBL5208387) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00378 BindingDB Entry DOI: 10.7270/Q2SF3151 | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 4 subunit alpha (Homo sapiens (Human)) | BDBM50344821 (10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 7.60 | n/a | n/a | n/a | n/a | n/a | n/a |
SiteOne Therapeutics Curated by ChEMBL | Assay Description Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assay | J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD | |||||||||||
More data for this Ligand-Target Pair |
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