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Compile Data Set for Download or QSAR

Found 448 hits with Last Name = 'dietz' and Initial = 'm'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50524862
PNG
(CHEMBL4475680)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2NC(=O)CCc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C21H19ClFN3O4/c22-14-7-12(8-15(23)10-14)11-24-19(28)21(30)5-6-26(20(21)29)16-2-3-17-13(9-16)1-4-18(27)25-17/h2-3,7-10,30H,1,4-6,11H2,(H,24,28)(H,25,27)/t21-/m0/s1
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 0.160n/an/an/an/an/an/an/an/a



Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50524862
PNG
(CHEMBL4475680)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2NC(=O)CCc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C21H19ClFN3O4/c22-14-7-12(8-15(23)10-14)11-24-19(28)21(30)5-6-26(20(21)29)16-2-3-17-13(9-16)1-4-18(27)25-17/h2-3,7-10,30H,1,4-6,11H2,(H,24,28)(H,25,27)/t21-/m0/s1
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 0.160n/an/an/an/an/an/an/an/a



Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM401307
PNG
(US10005756, Compound A78)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(F)c1 |r|
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 0.900n/an/an/an/an/an/an/an/a



Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM401307
PNG
(US10005756, Compound A78)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(F)c1 |r|
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 0.900n/an/an/an/an/an/an/an/a



Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531161
PNG
(CHEMBL4448724)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C19H16ClFN4O3/c20-13-5-11(6-14(21)8-13)9-24-17(26)19(28)2-4-25(18(19)27)15-7-12-1-3-22-16(12)23-10-15/h1,3,5-8,10,28H,2,4,9H2,(H,22,23)(H,24,26)/t19-/m0/s1
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 3.40n/an/an/an/an/an/an/an/a



Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531161
PNG
(CHEMBL4448724)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C19H16ClFN4O3/c20-13-5-11(6-14(21)8-13)9-24-17(26)19(28)2-4-25(18(19)27)15-7-12-1-3-22-16(12)23-10-15/h1,3,5-8,10,28H,2,4,9H2,(H,22,23)(H,24,26)/t19-/m0/s1
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 3.40n/an/an/an/an/an/an/an/a



Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531163
PNG
(CHEMBL4464946)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C20H17F2N3O3/c21-14-7-12(8-15(22)10-14)11-24-18(26)20(28)4-6-25(19(20)27)16-1-2-17-13(9-16)3-5-23-17/h1-3,5,7-10,23,28H,4,6,11H2,(H,24,26)/t20-/m0/s1
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 4.30n/an/an/an/an/an/an/an/a



Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531163
PNG
(CHEMBL4464946)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C20H17F2N3O3/c21-14-7-12(8-15(22)10-14)11-24-18(26)20(28)4-6-25(19(20)27)16-1-2-17-13(9-16)3-5-23-17/h1-3,5,7-10,23,28H,4,6,11H2,(H,24,26)/t20-/m0/s1
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 4.30n/an/an/an/an/an/an/an/a



Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50250422
PNG
((+)-N-methyl-laurotetanine | CHEMBL464099 | N-meth...)
Show SMILES COc1cc-2c(C[C@@H]3N(C)CCc4cc(OC)c(OC)c-2c34)cc1O |r|
Show InChI InChI=1S/C20H23NO4/c1-21-6-5-11-9-17(24-3)20(25-4)19-13-10-16(23-2)15(22)8-12(13)7-14(21)18(11)19/h8-10,14,22H,5-7H2,1-4H3/t14-/m0/s1
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 85n/an/an/an/an/an/an/an/a



Tom's of Maine

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells

J Nat Prod 69: 432-5 (2006)


Article DOI: 10.1021/np058114h
BindingDB Entry DOI: 10.7270/Q2V98907
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (Human))		BDBM50259677
PNG
(CHEMBL481839 | escholtzine)
Show SMILES CN1[C@H]2Cc3cc4OCOc4cc3[C@@H]1Cc1cc3OCOc3cc21 |r,TLB:0:1:14.15.23:3.12.4|
Show InChI InChI=1S/C19H17NO4/c1-20-14-2-10-4-16-18(23-8-21-16)6-12(10)15(20)3-11-5-17-19(7-13(11)14)24-9-22-17/h4-7,14-15H,2-3,8-9H2,1H3/t14-,15-/m0/s1
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 6.00E+3n/an/an/an/an/an/an/an/a



Tom's of Maine

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from human recombinant 5HT1A receptor expressed in CHO cells

J Nat Prod 69: 432-5 (2006)


Article DOI: 10.1021/np058114h
BindingDB Entry DOI: 10.7270/Q2V98907
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)		BDBM50089194
PNG
((R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-...)
Show SMILES CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO
Show InChI InChI=1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)/t14-,15+,17+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531149
PNG
(CHEMBL4572028)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]cc(Cl)c2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C19H15Cl2FN4O3/c20-11-3-10(4-12(22)5-11)7-25-17(27)19(29)1-2-26(18(19)28)13-6-14-15(21)9-24-16(14)23-8-13/h3-6,8-9,29H,1-2,7H2,(H,23,24)(H,25,27)/t19-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531149
PNG
(CHEMBL4572028)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]cc(Cl)c2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C19H15Cl2FN4O3/c20-11-3-10(4-12(22)5-11)7-25-17(27)19(29)1-2-26(18(19)28)13-6-14-15(21)9-24-16(14)23-8-13/h3-6,8-9,29H,1-2,7H2,(H,23,24)(H,25,27)/t19-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Macrophage metalloelastase


(Homo sapiens (Human))		BDBM50408913
PNG
(CHEMBL2092878)
Show SMILES CCCC[C@@H](CC(=O)NO)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C13H19NO4S/c1-2-3-7-12(10-13(15)14-16)19(17,18)11-8-5-4-6-9-11/h4-6,8-9,12,16H,2-3,7,10H2,1H3,(H,14,15)/t12-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Matrix metalloprotease-12

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))		BDBM50089199
PNG
(3-(Naphthalene-2-sulfonyl)-heptanoic acid hydroxya...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H21NO4S/c1-2-3-8-15(12-17(19)18-20)23(21,22)16-10-9-13-6-4-5-7-14(13)11-16/h4-7,9-11,15,20H,2-3,8,12H2,1H3,(H,18,19)
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n/an/a 9n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloprotease-13

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)		BDBM50089201
PNG
(3-(4-Acetylamino-benzenesulfonyl)-heptanoic acid h...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C15H22N2O5S/c1-3-4-5-14(10-15(19)17-20)23(21,22)13-8-6-12(7-9-13)16-11(2)18/h6-9,14,20H,3-5,10H2,1-2H3,(H,16,18)(H,17,19)
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n/an/a 11n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531146
PNG
(CHEMBL4463138)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C20H17ClFN3O3/c21-14-7-12(8-15(22)10-14)11-24-18(26)20(28)4-6-25(19(20)27)16-1-2-17-13(9-16)3-5-23-17/h1-3,5,7-10,23,28H,4,6,11H2,(H,24,26)/t20-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531146
PNG
(CHEMBL4463138)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C20H17ClFN3O3/c21-14-7-12(8-15(22)10-14)11-24-18(26)20(28)4-6-25(19(20)27)16-1-2-17-13(9-16)3-5-23-17/h1-3,5,7-10,23,28H,4,6,11H2,(H,24,26)/t20-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Macrophage metalloelastase


(Homo sapiens (Human))		BDBM50089196
PNG
(3-Benzenesulfonyl-heptanoic acid hydroxyamide | CH...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C13H19NO4S/c1-2-3-7-12(10-13(15)14-16)19(17,18)11-8-5-4-6-9-11/h4-6,8-9,12,16H,2-3,7,10H2,1H3,(H,14,15)
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F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Matrix metalloprotease-12

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM401308
PNG
(US10005756, Compound A79)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]cc(Cl)c2c1)C(=O)NCc1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C19H15ClF2N4O3/c20-15-9-24-16-14(15)6-13(8-23-16)26-2-1-19(29,18(26)28)17(27)25-7-10-3-11(21)5-12(22)4-10/h3-6,8-9,29H,1-2,7H2,(H,23,24)(H,25,27)/t19-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM401308
PNG
(US10005756, Compound A79)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]cc(Cl)c2c1)C(=O)NCc1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C19H15ClF2N4O3/c20-15-9-24-16-14(15)6-13(8-23-16)26-2-1-19(29,18(26)28)17(27)25-7-10-3-11(21)5-12(22)4-10/h3-6,8-9,29H,1-2,7H2,(H,23,24)(H,25,27)/t19-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Macrophage metalloelastase


(Homo sapiens (Human))		BDBM50089199
PNG
(3-(Naphthalene-2-sulfonyl)-heptanoic acid hydroxya...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H21NO4S/c1-2-3-8-15(12-17(19)18-20)23(21,22)16-10-9-13-6-4-5-7-14(13)11-16/h4-7,9-11,15,20H,2-3,8,12H2,1H3,(H,18,19)
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F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Matrix metalloprotease-12

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531155
PNG
(CHEMBL4553094)
Show SMILES Cc1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
Show InChI InChI=1S/C21H19ClFN3O3/c1-12-6-14-9-17(2-3-18(14)25-12)26-5-4-21(29,20(26)28)19(27)24-11-13-7-15(22)10-16(23)8-13/h2-3,6-10,25,29H,4-5,11H2,1H3,(H,24,27)/t21-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531162
PNG
(CHEMBL4445117)
Show SMILES CCNC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
Show InChI InChI=1S/C23H22ClFN4O4/c1-2-26-20(30)19-10-14-9-17(3-4-18(14)28-19)29-6-5-23(33,22(29)32)21(31)27-12-13-7-15(24)11-16(25)8-13/h3-4,7-11,28,33H,2,5-6,12H2,1H3,(H,26,30)(H,27,31)/t23-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531162
PNG
(CHEMBL4445117)
Show SMILES CCNC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
Show InChI InChI=1S/C23H22ClFN4O4/c1-2-26-20(30)19-10-14-9-17(3-4-18(14)28-19)29-6-5-23(33,22(29)32)21(31)27-12-13-7-15(24)11-16(25)8-13/h3-4,7-11,28,33H,2,5-6,12H2,1H3,(H,26,30)(H,27,31)/t23-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Macrophage metalloelastase


(Homo sapiens (Human))		BDBM50089198
PNG
(3-Cyclohexanesulfonyl-heptanoic acid hydroxyamide ...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)C1CCCCC1
Show InChI InChI=1S/C13H25NO4S/c1-2-3-7-12(10-13(15)14-16)19(17,18)11-8-5-4-6-9-11/h11-12,16H,2-10H2,1H3,(H,14,15)
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F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Matrix metalloprotease-12

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531155
PNG
(CHEMBL4553094)
Show SMILES Cc1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
Show InChI InChI=1S/C21H19ClFN3O3/c1-12-6-14-9-17(2-3-18(14)25-12)26-5-4-21(29,20(26)28)19(27)24-11-13-7-15(22)10-16(23)8-13/h2-3,6-10,25,29H,4-5,11H2,1H3,(H,24,27)/t21-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50524862
PNG
(CHEMBL4475680)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2NC(=O)CCc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C21H19ClFN3O4/c22-14-7-12(8-15(23)10-14)11-24-19(28)21(30)5-6-26(20(21)29)16-2-3-17-13(9-16)1-4-18(27)25-17/h2-3,7-10,30H,1,4-6,11H2,(H,24,28)(H,25,27)/t21-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50524862
PNG
(CHEMBL4475680)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2NC(=O)CCc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C21H19ClFN3O4/c22-14-7-12(8-15(23)10-14)11-24-19(28)21(30)5-6-26(20(21)29)16-2-3-17-13(9-16)1-4-18(27)25-17/h2-3,7-10,30H,1,4-6,11H2,(H,24,28)(H,25,27)/t21-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531157
PNG
(CHEMBL4550096)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2NC(=O)CCc2c1)C(=O)NCc1cc(F)cc(Cl)c1F |r|
Show InChI InChI=1S/C21H18ClF2N3O4/c22-15-9-13(23)7-12(18(15)24)10-25-19(29)21(31)5-6-27(20(21)30)14-2-3-16-11(8-14)1-4-17(28)26-16/h2-3,7-9,31H,1,4-6,10H2,(H,25,29)(H,26,28)/t21-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531157
PNG
(CHEMBL4550096)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2NC(=O)CCc2c1)C(=O)NCc1cc(F)cc(Cl)c1F |r|
Show InChI InChI=1S/C21H18ClF2N3O4/c22-15-9-13(23)7-12(18(15)24)10-25-19(29)21(31)5-6-27(20(21)30)14-2-3-16-11(8-14)1-4-17(28)26-16/h2-3,7-9,31H,1,4-6,10H2,(H,25,29)(H,26,28)/t21-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)		BDBM50369525
PNG
(CHEMBL1788203)
Show SMILES CCCC[C@H](CC(=O)NO)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C13H19NO4S/c1-2-3-7-12(10-13(15)14-16)19(17,18)11-8-5-4-6-9-11/h4-6,8-9,12,16H,2-3,7,10H2,1H3,(H,14,15)/t12-/m1/s1
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F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531161
PNG
(CHEMBL4448724)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C19H16ClFN4O3/c20-13-5-11(6-14(21)8-13)9-24-17(26)19(28)2-4-25(18(19)27)15-7-12-1-3-22-16(12)23-10-15/h1,3,5-8,10,28H,2,4,9H2,(H,22,23)(H,24,26)/t19-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531161
PNG
(CHEMBL4448724)
Show SMILES O[C@@]1(CCN(C1=O)c1cnc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C19H16ClFN4O3/c20-13-5-11(6-14(21)8-13)9-24-17(26)19(28)2-4-25(18(19)27)15-7-12-1-3-22-16(12)23-10-15/h1,3,5-8,10,28H,2,4,9H2,(H,22,23)(H,24,26)/t19-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531163
PNG
(CHEMBL4464946)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C20H17F2N3O3/c21-14-7-12(8-15(22)10-14)11-24-18(26)20(28)4-6-25(19(20)27)16-1-2-17-13(9-16)3-5-23-17/h1-3,5,7-10,23,28H,4,6,11H2,(H,24,26)/t20-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531163
PNG
(CHEMBL4464946)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]ccc2c1)C(=O)NCc1cc(F)cc(F)c1 |r|
Show InChI InChI=1S/C20H17F2N3O3/c21-14-7-12(8-15(22)10-14)11-24-18(26)20(28)4-6-25(19(20)27)16-1-2-17-13(9-16)3-5-23-17/h1-3,5,7-10,23,28H,4,6,11H2,(H,24,26)/t20-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Collagenase 3


(Homo sapiens (Human))		BDBM50089196
PNG
(3-Benzenesulfonyl-heptanoic acid hydroxyamide | CH...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C13H19NO4S/c1-2-3-7-12(10-13(15)14-16)19(17,18)11-8-5-4-6-9-11/h4-6,8-9,12,16H,2-3,7,10H2,1H3,(H,14,15)
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F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Matrix metalloprotease-13

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)		BDBM50089199
PNG
(3-(Naphthalene-2-sulfonyl)-heptanoic acid hydroxya...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C17H21NO4S/c1-2-3-8-15(12-17(19)18-20)23(21,22)16-10-9-13-6-4-5-7-14(13)11-16/h4-7,9-11,15,20H,2-3,8,12H2,1H3,(H,18,19)
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F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531150
PNG
(CHEMBL4460444)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]ncc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C19H16ClFN4O3/c20-13-5-11(6-14(21)8-13)9-22-17(26)19(28)3-4-25(18(19)27)15-1-2-16-12(7-15)10-23-24-16/h1-2,5-8,10,28H,3-4,9H2,(H,22,26)(H,23,24)/t19-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531150
PNG
(CHEMBL4460444)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2[nH]ncc2c1)C(=O)NCc1cc(F)cc(Cl)c1 |r|
Show InChI InChI=1S/C19H16ClFN4O3/c20-13-5-11(6-14(21)8-13)9-22-17(26)19(28)3-4-25(18(19)27)15-1-2-16-12(7-15)10-23-24-16/h1-2,5-8,10,28H,3-4,9H2,(H,22,26)(H,23,24)/t19-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)		BDBM50089209
PNG
(3-(4-Methoxy-benzenesulfonyl)-heptanoic acid hydro...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccc(OC)cc1
Show InChI InChI=1S/C14H21NO5S/c1-3-4-5-13(10-14(16)15-17)21(18,19)12-8-6-11(20-2)7-9-12/h6-9,13,17H,3-5,10H2,1-2H3,(H,15,16)
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F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM401275
PNG
(US10005756, Compound A40)
Show SMILES NCCCNC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM401275
PNG
(US10005756, Compound A40)
Show SMILES NCCCNC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Peptide deformylase


(Escherichia coli)		BDBM50089196
PNG
(3-Benzenesulfonyl-heptanoic acid hydroxyamide | CH...)
Show SMILES CCCCC(CC(=O)NO)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C13H19NO4S/c1-2-3-7-12(10-13(15)14-16)19(17,18)11-8-5-4-6-9-11/h4-6,8-9,12,16H,2-3,7,10H2,1H3,(H,14,15)
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F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531162
PNG
(CHEMBL4445117)
Show SMILES CCNC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
Show InChI InChI=1S/C23H22ClFN4O4/c1-2-26-20(30)19-10-14-9-17(3-4-18(14)28-19)29-6-5-23(33,22(29)32)21(31)27-12-13-7-15(24)11-16(25)8-13/h3-4,7-11,28,33H,2,5-6,12H2,1H3,(H,26,30)(H,27,31)/t23-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531162
PNG
(CHEMBL4445117)
Show SMILES CCNC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
Show InChI InChI=1S/C23H22ClFN4O4/c1-2-26-20(30)19-10-14-9-17(3-4-18(14)28-19)29-6-5-23(33,22(29)32)21(31)27-12-13-7-15(24)11-16(25)8-13/h3-4,7-11,28,33H,2,5-6,12H2,1H3,(H,26,30)(H,27,31)/t23-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Macrophage metalloelastase


(Homo sapiens (Human))		BDBM50369525
PNG
(CHEMBL1788203)
Show SMILES CCCC[C@H](CC(=O)NO)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C13H19NO4S/c1-2-3-7-12(10-13(15)14-16)19(17,18)11-8-5-4-6-9-11/h4-6,8-9,12,16H,2-3,7,10H2,1H3,(H,14,15)/t12-/m1/s1
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n/an/a 42n/an/an/an/an/an/a



F. Hoffmann-La Roche Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Matrix metalloprotease-12

J Med Chem 43: 2324-31 (2000)


BindingDB Entry DOI: 10.7270/Q2QF8TJR
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531148
PNG
(CHEMBL4551283)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2NC(=O)CCc2c1)C(=O)NCc1cc(F)cc(F)c1F |r|
Show InChI InChI=1S/C21H18F3N3O4/c22-13-7-12(18(24)15(23)9-13)10-25-19(29)21(31)5-6-27(20(21)30)14-2-3-16-11(8-14)1-4-17(28)26-16/h2-3,7-9,31H,1,4-6,10H2,(H,25,29)(H,26,28)/t21-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531148
PNG
(CHEMBL4551283)
Show SMILES O[C@@]1(CCN(C1=O)c1ccc2NC(=O)CCc2c1)C(=O)NCc1cc(F)cc(F)c1F |r|
Show InChI InChI=1S/C21H18F3N3O4/c22-13-7-12(18(24)15(23)9-13)10-25-19(29)21(31)5-6-27(20(21)30)14-2-3-16-11(8-14)1-4-17(28)26-16/h2-3,7-9,31H,1,4-6,10H2,(H,25,29)(H,26,28)/t21-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50531154
PNG
(CHEMBL4448427)
Show SMILES CS(=O)(=O)Nc1cccc(c1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
Show InChI InChI=1S/C19H19ClFN3O5S/c1-30(28,29)23-15-3-2-4-16(10-15)24-6-5-19(27,18(24)26)17(25)22-11-12-7-13(20)9-14(21)8-12/h2-4,7-10,23,27H,5-6,11H2,1H3,(H,22,25)/t19-/m0/s1
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Merck Healthcare

Curated by ChEMBL


Assay Description
Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assay

J Med Chem 62: 11119-11134 (2019)


Article DOI: 10.1021/acs.jmedchem.9b01070
BindingDB Entry DOI: 10.7270/Q26H4MXQ
More data for this
Ligand-Target Pair
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