BindingDB PrimarySearch

BDBM50089194 (R)-N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide::(R)-N4-hydroxy-N1-((S)-1-((S)-2-(hydroxymethyl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)-2-pentylsuccinamide::ACTINONIN::CHEMBL308333::N*4*-Hydroxy-N*1*-[(S)-1-((S)-2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-(R)-pentyl-succinamide::N*4*-Hydroxy-N*1*-[1-(2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methyl-propyl]-2-pentyl-succinamide

SMILES: CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO

InChI Key: InChIKey=XJLATMLVMSFZBN-VYDXJSESSA-N

Data: 10 KI 24 IC50

PDB links: 38 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 50089194
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Peptide deformylase mitochondrial (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Senju Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description Binding affinity of the compound towards Peptide deformylase				Bioorg Med Chem Lett 13: 3273-6 (2003) BindingDB Entry DOI: 10.7270/Q2FN15MQ
Senju Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Aminopeptidase (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Jadavpur University Curated by ChEMBL					Assay Description Competitive inhibition of aminopeptidase-M (unknown origin)				J Med Chem 61: 6468-6490 (2018) Article DOI: 10.1021/acs.jmedchem.7b00782 BindingDB Entry DOI: 10.7270/Q28S4SHS
Jadavpur University Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil collagenase (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human Matrix metalloproteinase-8				Bioorg Med Chem Lett 5: 349-352 (1995) Article DOI: 10.1016/0960-894X(95)00033-P BindingDB Entry DOI: 10.7270/Q2DR2VG9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human fibroblast collagenase, matrix metalloproteinase-1				Bioorg Med Chem Lett 5: 349-352 (1995) Article DOI: 10.1016/0960-894X(95)00033-P BindingDB Entry DOI: 10.7270/Q2DR2VG9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Matrix metalloproteinase-9 (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human Matrix metalloproteinase-9				Bioorg Med Chem Lett 5: 349-352 (1995) Article DOI: 10.1016/0960-894X(95)00033-P BindingDB Entry DOI: 10.7270/Q2DR2VG9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of human fibroblast stromelysin, matrix metalloproteinase-3				Bioorg Med Chem Lett 5: 349-352 (1995) Article DOI: 10.1016/0960-894X(95)00033-P BindingDB Entry DOI: 10.7270/Q2DR2VG9
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Meprin A subunit beta (Homo sapiens)	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fraunhofer Institute for Cell Therapy and Immunology IZI Curated by ChEMBL					Assay Description Inhibition of human meprin beta expressed in baculovirus infected BTI-TN-5B1-4 insect cells using N-benzoyl-L-tyrosylp-aminobenzoic acid as substrate				Bioorg Med Chem Lett 27: 2428-2431 (2017) Article DOI: 10.1016/j.bmcl.2017.04.012 BindingDB Entry DOI: 10.7270/Q2CR5WH0
					More data for this Ligand-Target Pair
Meprin A subunit beta (Homo sapiens)	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fraunhofer Institute for Cell Therapy and Immunology IZI Curated by ChEMBL					Assay Description Inhibition of recombinant human meprin beta expressed in baculovirus infected insect cells using N-benzoyl-L-tyrosyl-p-aminobenzoic acid as substrate				J Med Chem 61: 4578-4592 (2018) Article DOI: 10.1021/acs.jmedchem.8b00330 BindingDB Entry DOI: 10.7270/Q2KS6V47
					More data for this Ligand-Target Pair
Aminopeptidase (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of APM (unknown origin) assessed as inhibition of endomorphin-2 degradation after 30 min				Med Chem Res 21: 1445-1450 (2012) Article DOI: 10.1007/s00044-011-9666-5 BindingDB Entry DOI: 10.7270/Q2NP27BJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	3.90E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of APM (unknown origin) assessed as inhibition of endomorphin-1 degradation after 30 min				Med Chem Res 21: 1445-1450 (2012) Article DOI: 10.1007/s00044-011-9666-5 BindingDB Entry DOI: 10.7270/Q2NP27BJ
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Peptide deformylase (Escherichia coli)	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Inhibitory activity against isolated Escherichia coli peptidyl deformylase (PDF) enzyme containing iron.				J Med Chem 43: 2324-31 (2000) BindingDB Entry DOI: 10.7270/Q2QF8TJR
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin) using Boc-Lys(Ac)-pNA as substrate preincubated for 20 mins followed by substrate addition and further incubated...				J Med Chem 63: 6959-6978 (2020)
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Peptide deformylase mitochondrial (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Centre National de la Recherche Scientifique Curated by ChEMBL					Assay Description Inhibition of human mitochondrial PDF				J Med Chem 50: 10-20 (2007) Article DOI: 10.1021/jm060910c BindingDB Entry DOI: 10.7270/Q22Z16B7
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peptide deformylase (Escherichia coli)	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Centre National de la Recherche Scientifique Curated by ChEMBL					Assay Description Inhibition of PDF1B				J Med Chem 50: 10-20 (2007) Article DOI: 10.1021/jm060910c BindingDB Entry DOI: 10.7270/Q22Z16B7
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peptide deformylase mitochondrial (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
Senju Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description In vitro inhibitory concentration required against peptide deformylase (PDF)				Bioorg Med Chem Lett 13: 3273-6 (2003) BindingDB Entry DOI: 10.7270/Q2FN15MQ
Senju Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Peptide deformylase (Staphylococcus aureus)	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Korea Research Institute of Bioscience and Biotechnology Curated by ChEMBL					Assay Description Inhibition of Staphylococcus aureus peptide deformylase using N-formylmethionine-alanine-serine as substrate by spectrophotometry				J Nat Prod 75: 271-4 (2012) Article DOI: 10.1021/np200720v BindingDB Entry DOI: 10.7270/Q24B3299
					More data for this Ligand-Target Pair				3D Structure (crystal)
Peptide deformylase (Staphylococcus aureus (strain Mu50 / ATCC 700699))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	<5	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL					Assay Description Inhibitory activity towards Ni-peptide deformylase of Staphylococcus aureus				Bioorg Med Chem Lett 14: 1477-81 (2004) Article DOI: 10.1016/j.bmcl.2004.01.014 BindingDB Entry DOI: 10.7270/Q2MS3S6G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Aminopeptidase (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Jadavpur University Curated by ChEMBL					Assay Description Competitive inhibition of aminopeptidase-M (unknown origin)				J Med Chem 61: 6468-6490 (2018) Article DOI: 10.1021/acs.jmedchem.7b00782 BindingDB Entry DOI: 10.7270/Q28S4SHS
Jadavpur University Curated by ChEMBL					More data for this Ligand-Target Pair
Aminopeptidase (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	830	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against aminopeptidase N assayed by the L-Ala-MCA method.				J Med Chem 41: 263-5 (1998) Article DOI: 10.1021/jm970624o BindingDB Entry DOI: 10.7270/Q24X5BJC
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>2.59E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against dipeptidyl peptidase IV (DPP- IV)				J Med Chem 41: 263-5 (1998) Article DOI: 10.1021/jm970624o BindingDB Entry DOI: 10.7270/Q24X5BJC
University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Peptide deformylase mitochondrial (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDF using N-formylated peptide as substrate in presence of NAD+ by formate dehydrogenase-coupled spectrophotometric assay				J Med Chem 63: 6959-6978 (2020)
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Peptide deformylase mitochondrial (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human PDF expressed in Escherichia coli BL21 pLysS using formyl-Met-Ala-His-Ala peptide as substrate measured after 1 hr by fluorescami...				J Med Chem 63: 6959-6978 (2020)
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Cereblon/Histone deacetylase 1 (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of HDAC1 (unknown origin) using Boc-Lys(Ac)-pNA as substrate preincubated for 20 mins followed by substrate addition and further incubated...				J Med Chem 63: 6959-6978 (2020)
Sun Yat-sen University Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelin-converting enzyme 1 (ECE1) (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against human bronchiolar smooth muscle Endothelin-converting enzyme 1				J Med Chem 38: 2119-29 (1995) BindingDB Entry DOI: 10.7270/Q2D79C2M
Berlex Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Peptide deformylase (Escherichia coli)	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by ChEMBL					Assay Description Inhibition of Escherichia coli peptide deformylase using fMAHA as substrate after 1 hr by FLUO assay				Bioorg Med Chem Lett 21: 4528-32 (2011) Article DOI: 10.1016/j.bmcl.2011.05.129 BindingDB Entry DOI: 10.7270/Q2VT1SGT
Memorial Sloan-Kettering Cancer Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Peptide deformylase mitochondrial (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by ChEMBL					Assay Description Inhibition of human peptide deformylase after 1 hr by fluorescence polarization based competition assay				Bioorg Med Chem Lett 21: 4528-32 (2011) Article DOI: 10.1016/j.bmcl.2011.05.129 BindingDB Entry DOI: 10.7270/Q2VT1SGT
Memorial Sloan-Kettering Cancer Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Angiotensin-converting enzyme (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
British Biotech Pharmaceuticals Limited Curated by ChEMBL					Assay Description Compound was tested for its inhibitory activity against Angiotensin I converting enzyme				Bioorg Med Chem Lett 11: 2585-8 (2001) BindingDB Entry DOI: 10.7270/Q2SN0886
British Biotech Pharmaceuticals Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	6.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
British Biotech Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of Matrix metalloproteinase-3				Bioorg Med Chem Lett 11: 2585-8 (2001) BindingDB Entry DOI: 10.7270/Q2SN0886
British Biotech Pharmaceuticals Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Peptide deformylase mitochondrial (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
British Biotech Pharmaceuticals Limited Curated by ChEMBL					Assay Description Antibacterial activity of the compound against E. coli Peptide deformylase. Ni				Bioorg Med Chem Lett 11: 2585-8 (2001) BindingDB Entry DOI: 10.7270/Q2SN0886
British Biotech Pharmaceuticals Limited Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
British Biotech Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of Matrix metalloproteinase-2				Bioorg Med Chem Lett 11: 2585-8 (2001) BindingDB Entry DOI: 10.7270/Q2SN0886
British Biotech Pharmaceuticals Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Neprilysin (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
British Biotech Pharmaceuticals Limited Curated by ChEMBL					Assay Description The compound was evaluated in vitro for the inhibition of Neutral endopeptidase				Bioorg Med Chem Lett 11: 2585-8 (2001) BindingDB Entry DOI: 10.7270/Q2SN0886
British Biotech Pharmaceuticals Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Interstitial collagenase (Homo sapiens (Human))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
British Biotech Pharmaceuticals Limited Curated by ChEMBL					Assay Description Inhibition of human Matrix metalloproteinase-1				Bioorg Med Chem Lett 11: 2585-8 (2001) BindingDB Entry DOI: 10.7270/Q2SN0886
British Biotech Pharmaceuticals Limited Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
Neprilysin (Oryctolagus cuniculus (rabbit))	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against big ET-1 of Neutral endopeptidase				J Med Chem 38: 2119-29 (1995) BindingDB Entry DOI: 10.7270/Q2D79C2M
Berlex Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Peptide deformylase 1A, chloroplastic (Arabidopsis thaliana)	BDBM50089194 ((R)-N4-Hydroxy-N1-[(S)-1-((S)-2-hydroxymethyl-...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
Centre National de la Recherche Scientifique Curated by ChEMBL					Assay Description Inhibition of Arabidopsis thaliana mitochondrial PDF1A				J Med Chem 50: 10-20 (2007) Article DOI: 10.1021/jm060910c BindingDB Entry DOI: 10.7270/Q22Z16B7
					More data for this Ligand-Target Pair				3D Structure (crystal)