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Compile Data Set for Download or QSAR

Found 47 hits with Last Name = 'wright' and Initial = 'mh'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50027680
PNG
(CHEMBL3357975)
Show SMILES N[C@@H](CC(=O)N1C[C@H](CO)[C@H](C1)c1ccc(Cl)c(NC(=O)Cc2ccc(F)cc2)c1)Cc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C29H30Cl2FN3O3/c30-22-6-1-18(2-7-22)11-24(33)14-29(38)35-15-21(17-36)25(16-35)20-5-10-26(31)27(13-20)34-28(37)12-19-3-8-23(32)9-4-19/h1-10,13,21,24-25,36H,11-12,14-17,33H2,(H,34,37)/t21-,24-,25-/m1/s1
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 27n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay

J Med Chem 57: 8664-70 (2014)


Article DOI: 10.1021/jm5011397
BindingDB Entry DOI: 10.7270/Q2X63PJN
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50027677
PNG
(CHEMBL3344387)
Show SMILES N[C@@H](CC(=O)N1C[C@H](CO)[C@H](C1)c1ccc(Cl)cc1)Cc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H24Cl2N2O2/c22-17-5-1-14(2-6-17)9-19(24)10-21(27)25-11-16(13-26)20(12-25)15-3-7-18(23)8-4-15/h1-8,16,19-20,26H,9-13,24H2/t16-,19-,20-/m1/s1
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 631n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay

J Med Chem 57: 8664-70 (2014)


Article DOI: 10.1021/jm5011397
BindingDB Entry DOI: 10.7270/Q2X63PJN
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50027681
PNG
(CHEMBL3357976)
Show SMILES OC[C@H]1CN(C[C@@H]1c1ccc(Cl)c(NC(=O)Cc2ccc(F)cc2)c1)C(=O)CC(O)Cc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C29H29Cl2FN2O4/c30-22-6-1-18(2-7-22)11-24(36)14-29(38)34-15-21(17-35)25(16-34)20-5-10-26(31)27(13-20)33-28(37)12-19-3-8-23(32)9-4-19/h1-10,13,21,24-25,35-36H,11-12,14-17H2,(H,33,37)/t21-,24?,25-/m1/s1
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 1.71E+3n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay

J Med Chem 57: 8664-70 (2014)


Article DOI: 10.1021/jm5011397
BindingDB Entry DOI: 10.7270/Q2X63PJN
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50027679
PNG
(CHEMBL3344389)
Show SMILES CC(=O)Nc1cc(ccc1Cl)[C@H]1CN(C[C@@H]1CO)C(=O)C[C@H](N)Cc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C23H27Cl2N3O3/c1-14(30)27-22-9-16(4-7-21(22)25)20-12-28(11-17(20)13-29)23(31)10-19(26)8-15-2-5-18(24)6-3-15/h2-7,9,17,19-20,29H,8,10-13,26H2,1H3,(H,27,30)/t17-,19-,20-/m1/s1
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 4.91E+3n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay

J Med Chem 57: 8664-70 (2014)


Article DOI: 10.1021/jm5011397
BindingDB Entry DOI: 10.7270/Q2X63PJN
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50027678
PNG
(CHEMBL3344388)
Show SMILES N[C@@H](CC(=O)N1C[C@@H](CO)[C@@H](C1)c1ccc(Cl)cc1)Cc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H24Cl2N2O2/c22-17-5-1-14(2-6-17)9-19(24)10-21(27)25-11-16(13-26)20(12-25)15-3-7-18(23)8-4-15/h1-8,16,19-20,26H,9-13,24H2/t16-,19+,20-/m0/s1
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 1.09E+4n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay

J Med Chem 57: 8664-70 (2014)


Article DOI: 10.1021/jm5011397
BindingDB Entry DOI: 10.7270/Q2X63PJN
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50027676
PNG
(CHEMBL3344386)
Show SMILES Fc1ccc(CC(=O)Nc2ccc3[nH]cc(C4CCNCC4)c3c2)cc1
Show InChI InChI=1S/C21H22FN3O/c22-16-3-1-14(2-4-16)11-21(26)25-17-5-6-20-18(12-17)19(13-24-20)15-7-9-23-10-8-15/h1-6,12-13,15,23-24H,7-11H2,(H,25,26)
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 2.85E+4n/an/an/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay

J Med Chem 57: 8664-70 (2014)


Article DOI: 10.1021/jm5011397
BindingDB Entry DOI: 10.7270/Q2X63PJN
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539993
PNG
(CHEMBL4647500)
Show SMILES CCN(C)c1nc(nc2ccc(cc12)S(=O)(=O)Nc1c(C)nn(C)c1C)N(C)C1CCN(C)C1
Show InChI InChI=1S/C23H34N8O2S/c1-8-29(5)22-19-13-18(34(32,33)27-21-15(2)26-31(7)16(21)3)9-10-20(19)24-23(25-22)30(6)17-11-12-28(4)14-17/h9-10,13,17,27H,8,11-12,14H2,1-7H3
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n/an/a 180n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539980
PNG
(CHEMBL4644304)
Show SMILES CN(CCC#N)c1nc(nc2cc(sc12)C(C)(C)C)N(C)C1CCN(C)CC1
Show InChI InChI=1S/C21H32N6S/c1-21(2,3)17-14-16-18(28-17)19(26(5)11-7-10-22)24-20(23-16)27(6)15-8-12-25(4)13-9-15/h14-15H,7-9,11-13H2,1-6H3
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n/an/a 550n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539992
PNG
(CHEMBL4632916)
Show SMILES CCN(C)c1nc(nc2ccc(cc12)S(=O)(=O)Nc1c(C)nn(C)c1C)N(C)CCCN(C)C
Show InChI InChI=1S/C23H36N8O2S/c1-9-29(6)22-19-15-18(34(32,33)27-21-16(2)26-31(8)17(21)3)11-12-20(19)24-23(25-22)30(7)14-10-13-28(4)5/h11-12,15,27H,9-10,13-14H2,1-8H3
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n/an/a 1.10E+3n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50027677
PNG
(CHEMBL3344387)
Show SMILES N[C@@H](CC(=O)N1C[C@H](CO)[C@H](C1)c1ccc(Cl)cc1)Cc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H24Cl2N2O2/c22-17-5-1-14(2-6-17)9-19(24)10-21(27)25-11-16(13-26)20(12-25)15-3-7-18(23)8-4-15/h1-8,16,19-20,26H,9-13,24H2/t16-,19-,20-/m1/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay

J Med Chem 57: 8664-70 (2014)


Article DOI: 10.1021/jm5011397
BindingDB Entry DOI: 10.7270/Q2X63PJN
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539975
PNG
(CHEMBL4633418)
Show SMILES CN(C1CCNCC1)c1nc(N2CCC[C@H]2CC#N)c2sccc2n1 |r|
Show InChI InChI=1S/C18H24N6S/c1-23(13-5-9-20-10-6-13)18-21-15-7-12-25-16(15)17(22-18)24-11-2-3-14(24)4-8-19/h7,12-14,20H,2-6,9-11H2,1H3/t14-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539991
PNG
(CHEMBL4632704)
Show SMILES CCN(C)c1nc(nc2ccc(cc12)S(=O)(=O)Nc1c(C)nn(C)c1C)N(C)C1CCNCC1
Show InChI InChI=1S/C23H34N8O2S/c1-7-29(4)22-19-14-18(34(32,33)28-21-15(2)27-31(6)16(21)3)8-9-20(19)25-23(26-22)30(5)17-10-12-24-13-11-17/h8-9,14,17,24,28H,7,10-13H2,1-6H3
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n/an/a 1.70E+3n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539990
PNG
(CHEMBL4647034)
Show SMILES CCN(C)c1nc(nc2ccc(cc12)S(=O)(=O)Nc1c(C)nn(C)c1C)N(C)C1CCN(C)CC1
Show InChI InChI=1S/C24H36N8O2S/c1-8-30(5)23-20-15-19(35(33,34)28-22-16(2)27-32(7)17(22)3)9-10-21(20)25-24(26-23)31(6)18-11-13-29(4)14-12-18/h9-10,15,18,28H,8,11-14H2,1-7H3
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n/an/a 2.30E+3n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539972
PNG
(CHEMBL4638503)
Show SMILES COC[C@@H]1CCCN1c1nc(nc2ccsc12)N(C)C1CCNCC1 |r|
Show InChI InChI=1S/C18H27N5OS/c1-22(13-5-8-19-9-6-13)18-20-15-7-11-25-16(15)17(21-18)23-10-3-4-14(23)12-24-2/h7,11,13-14,19H,3-6,8-10,12H2,1-2H3/t14-/m0/s1
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n/an/a 5.00E+3n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539956
PNG
(CHEMBL4634852)
Show SMILES CN(CCC#N)c1nc(nc2ccsc12)N(C)C1CCN(C)CC1
Show InChI InChI=1S/C17H24N6S/c1-21-10-5-13(6-11-21)23(3)17-19-14-7-12-24-15(14)16(20-17)22(2)9-4-8-18/h7,12-13H,4-6,9-11H2,1-3H3
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n/an/a 5.70E+3n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539977
PNG
(CHEMBL4634504)
Show SMILES CCN(C)c1nc(nc2ccsc12)N(C)C1CCN(C)CC1
Show InChI InChI=1S/C16H25N5S/c1-5-20(3)15-14-13(8-11-22-14)17-16(18-15)21(4)12-6-9-19(2)10-7-12/h8,11-12H,5-7,9-10H2,1-4H3
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n/an/a 7.90E+3n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539962
PNG
(CHEMBL4638689)
Show SMILES CN(CCC#N)c1nc(nc2ccsc12)N(C)C1CCNCC1
Show InChI InChI=1S/C16H22N6S/c1-21(10-3-7-17)15-14-13(6-11-23-14)19-16(20-15)22(2)12-4-8-18-9-5-12/h6,11-12,18H,3-5,8-10H2,1-2H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539958
PNG
(CHEMBL4642741)
Show SMILES CN(CCC#N)c1nc(nc2ccccc12)N(C)C1CCN(C)CC1
Show InChI InChI=1S/C19H26N6/c1-23-13-9-15(10-14-23)25(3)19-21-17-8-5-4-7-16(17)18(22-19)24(2)12-6-11-20/h4-5,7-8,15H,6,9-10,12-14H2,1-3H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539976
PNG
(CHEMBL4641086)
Show SMILES CN(C)CCCN(C)c1nc(N2CCC[C@H]2CC#N)c2sccc2n1 |r|
Show InChI InChI=1S/C18H26N6S/c1-22(2)10-5-11-23(3)18-20-15-8-13-25-16(15)17(21-18)24-12-4-6-14(24)7-9-19/h8,13-14H,4-7,10-12H2,1-3H3/t14-/m0/s1
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n/an/a 1.60E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539963
PNG
(CHEMBL4637123)
Show SMILES CCN1CCC(CC1)N(C)c1nc(N(C)CCC#N)c2sccc2n1
Show InChI InChI=1S/C18H26N6S/c1-4-24-11-6-14(7-12-24)23(3)18-20-15-8-13-25-16(15)17(21-18)22(2)10-5-9-19/h8,13-14H,4-7,10-12H2,1-3H3
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n/an/a 1.70E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539973
PNG
(CHEMBL4641649)
Show SMILES COC[C@@H]1CCCN1c1nc(nc2ccsc12)N(C)CCCN(C)C |r|
Show InChI InChI=1S/C18H29N5OS/c1-21(2)9-6-10-22(3)18-19-15-8-12-25-16(15)17(20-18)23-11-5-7-14(23)13-24-4/h8,12,14H,5-7,9-11,13H2,1-4H3/t14-/m0/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50027678
PNG
(CHEMBL3344388)
Show SMILES N[C@@H](CC(=O)N1C[C@@H](CO)[C@@H](C1)c1ccc(Cl)cc1)Cc1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C21H24Cl2N2O2/c22-17-5-1-14(2-6-17)9-19(24)10-21(27)25-11-16(13-26)20(12-25)15-3-7-18(23)8-4-15/h1-8,16,19-20,26H,9-13,24H2/t16-,19+,20-/m0/s1
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n/an/a 2.40E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay

J Med Chem 57: 8664-70 (2014)


Article DOI: 10.1021/jm5011397
BindingDB Entry DOI: 10.7270/Q2X63PJN
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539981
PNG
(CHEMBL4640420)
Show SMILES CN(CCC#N)c1nc(nc2cc(sc12)C(C)(C)C)N(C)C1CCN(C)C1
Show InChI InChI=1S/C20H30N6S/c1-20(2,3)16-12-15-17(27-16)18(25(5)10-7-9-21)23-19(22-15)26(6)14-8-11-24(4)13-14/h12,14H,7-8,10-11,13H2,1-6H3
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n/an/a 3.10E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539978
PNG
(CHEMBL4639250)
Show SMILES CCN(C)c1nc(nc2ccsc12)N(C)C1CCNCC1
Show InChI InChI=1S/C15H23N5S/c1-4-19(2)14-13-12(7-10-21-13)17-15(18-14)20(3)11-5-8-16-9-6-11/h7,10-11,16H,4-6,8-9H2,1-3H3
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n/an/a 3.30E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539966
PNG
(CHEMBL4634547)
Show SMILES CN[C@H]1CCN(C[C@@H]1F)c1nc(N(C)CCC#N)c2sccc2n1 |r|
Show InChI InChI=1S/C16H21FN6S/c1-19-12-4-8-23(10-11(12)17)16-20-13-5-9-24-14(13)15(21-16)22(2)7-3-6-18/h5,9,11-12,19H,3-4,7-8,10H2,1-2H3/t11-,12-/m0/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539965
PNG
(CHEMBL4642301)
Show SMILES CCNC1CCN(CC1)c1nc(N(C)CCC#N)c2sccc2n1
Show InChI InChI=1S/C17H24N6S/c1-3-19-13-5-10-23(11-6-13)17-20-14-7-12-24-15(14)16(21-17)22(2)9-4-8-18/h7,12-13,19H,3-6,9-11H2,1-2H3
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n/an/a 4.60E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50027676
PNG
(CHEMBL3344386)
Show SMILES Fc1ccc(CC(=O)Nc2ccc3[nH]cc(C4CCNCC4)c3c2)cc1
Show InChI InChI=1S/C21H22FN3O/c22-16-3-1-14(2-4-16)11-21(26)25-17-5-6-20-18(12-17)19(13-24-20)15-7-9-23-10-8-15/h1-6,12-13,15,23-24H,7-11H2,(H,25,26)
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n/an/a 6.30E+4n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using GSNKSKPKDASQRRR-NH2 as substrate by CPM fluorescence assay

J Med Chem 57: 8664-70 (2014)


Article DOI: 10.1021/jm5011397
BindingDB Entry DOI: 10.7270/Q2X63PJN
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539989
PNG
(CHEMBL4644841)
Show SMILES COc1ccc(c(C)c1)-c1ccc2nc(nc(N(C)CCC#N)c2c1)N(C)CCCN(C)C
Show InChI InChI=1S/C26H34N6O/c1-19-17-21(33-6)10-11-22(19)20-9-12-24-23(18-20)25(31(4)15-7-13-27)29-26(28-24)32(5)16-8-14-30(2)3/h9-12,17-18H,7-8,14-16H2,1-6H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539988
PNG
(CHEMBL4641823)
Show SMILES CN(C)CCCN(C)c1nc(N(C)CCC#N)c2cc(ccc2n1)-c1ccccc1C
Show InChI InChI=1S/C25H32N6/c1-19-10-6-7-11-21(19)20-12-13-23-22(18-20)24(30(4)16-8-14-26)28-25(27-23)31(5)17-9-15-29(2)3/h6-7,10-13,18H,8-9,15-17H2,1-5H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539987
PNG
(CHEMBL4643976)
Show SMILES CN(C)CCCN(C)c1nc(N(C)CCC#N)c2cc(ccc2n1)-c1ccccc1
Show InChI InChI=1S/C24H30N6/c1-28(2)15-9-17-30(4)24-26-22-13-12-20(19-10-6-5-7-11-19)18-21(22)23(27-24)29(3)16-8-14-25/h5-7,10-13,18H,8-9,15-17H2,1-4H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539986
PNG
(CHEMBL4638924)
Show SMILES COc1ccc2nc(nc(N(C)CCC#N)c2c1)N(C)CCCN(C)C
Show InChI InChI=1S/C19H28N6O/c1-23(2)11-7-13-25(4)19-21-17-9-8-15(26-5)14-16(17)18(22-19)24(3)12-6-10-20/h8-9,14H,6-7,11-13H2,1-5H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539985
PNG
(CHEMBL4646966)
Show SMILES COc1ccc2nc(nc(N(C)CCC#N)c2c1)N(C)C1CCN(C)CC1
Show InChI InChI=1S/C20H28N6O/c1-24-12-8-15(9-13-24)26(3)20-22-18-7-6-16(27-4)14-17(18)19(23-20)25(2)11-5-10-21/h6-7,14-15H,5,8-9,11-13H2,1-4H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539984
PNG
(CHEMBL4641691)
Show SMILES CN(CCC#N)c1nc(nc2ccc(Br)cc12)N(C)C1CCN(C)C1
Show InChI InChI=1S/C18H23BrN6/c1-23-10-7-14(12-23)25(3)18-21-16-6-5-13(19)11-15(16)17(22-18)24(2)9-4-8-20/h5-6,11,14H,4,7,9-10,12H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539983
PNG
(CHEMBL4643474)
Show SMILES CN(CCC#N)c1nc(nc2ccc(Br)cc12)N(C)C1CCN(C)CC1
Show InChI InChI=1S/C19H25BrN6/c1-24-11-7-15(8-12-24)26(3)19-22-17-6-5-14(20)13-16(17)18(23-19)25(2)10-4-9-21/h5-6,13,15H,4,7-8,10-12H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539982
PNG
(CHEMBL4642112)
Show SMILES CN(CCC#N)c1nc(nc2cc(sc12)C(C)(C)C)N(C)C1CCNC1
Show InChI InChI=1S/C19H28N6S/c1-19(2,3)15-11-14-16(26-15)17(24(4)10-6-8-20)23-18(22-14)25(5)13-7-9-21-12-13/h11,13,21H,6-7,9-10,12H2,1-5H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539979
PNG
(CHEMBL4649765)
Show SMILES CCN(C)c1nc(nc2ccsc12)N(C)CCCN(C)C
Show InChI InChI=1S/C15H25N5S/c1-6-19(4)14-13-12(8-11-21-13)16-15(17-14)20(5)10-7-9-18(2)3/h8,11H,6-7,9-10H2,1-5H3
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Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539974
PNG
(CHEMBL4635262)
Show SMILES CN(C1CCN(C)CC1)c1nc(N2CCC[C@H]2CC#N)c2sccc2n1 |r|
Show InChI InChI=1S/C19H26N6S/c1-23-11-6-14(7-12-23)24(2)19-21-16-8-13-26-17(16)18(22-19)25-10-3-4-15(25)5-9-20/h8,13-15H,3-7,10-12H2,1-2H3/t15-/m0/s1
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Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539971
PNG
(CHEMBL4639906)
Show SMILES COC[C@@H]1CCCN1c1nc(nc2ccsc12)N(C)C1CCN(C)CC1 |r|
Show InChI InChI=1S/C19H29N5OS/c1-22-10-6-14(7-11-22)23(2)19-20-16-8-12-26-17(16)18(21-19)24-9-4-5-15(24)13-25-3/h8,12,14-15H,4-7,9-11,13H2,1-3H3/t15-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539970
PNG
(CHEMBL4648485)
Show SMILES CN(C)CCCN(C)c1nc(N(C)CCN(C)C(C)=O)c2sccc2n1
Show InChI InChI=1S/C18H30N6OS/c1-14(25)22(4)11-12-23(5)17-16-15(8-13-26-16)19-18(20-17)24(6)10-7-9-21(2)3/h8,13H,7,9-12H2,1-6H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539969
PNG
(CHEMBL4644983)
Show SMILES [H][C@]12CC[C@]([H])(C[C@@H](C1)N(C)c1nc(N(C)CCC#N)c3ccccc3n1)N2C |r,TLB:28:27:2.3:7.8.6|
Show InChI InChI=1S/C21H28N6/c1-25(12-6-11-22)20-18-7-4-5-8-19(18)23-21(24-20)27(3)17-13-15-9-10-16(14-17)26(15)2/h4-5,7-8,15-17H,6,9-10,12-14H2,1-3H3/t15-,16+,17+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539968
PNG
(CHEMBL4645634)
Show SMILES CN(CCC#N)c1nc(nc2ccccc12)N(C)C1CCNCC1
Show InChI InChI=1S/C18H24N6/c1-23(13-5-10-19)17-15-6-3-4-7-16(15)21-18(22-17)24(2)14-8-11-20-12-9-14/h3-4,6-7,14,20H,5,8-9,11-13H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539967
PNG
(CHEMBL4649184)
Show SMILES CN[C@H]1CCN(C[C@H]1F)c1nc(N(C)CCC#N)c2sccc2n1 |r|
Show InChI InChI=1S/C16H21FN6S/c1-19-12-4-8-23(10-11(12)17)16-20-13-5-9-24-14(13)15(21-16)22(2)7-3-6-18/h5,9,11-12,19H,3-4,7-8,10H2,1-2H3/t11-,12+/m1/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539964
PNG
(CHEMBL4636010)
Show SMILES CC(C)CN1CCC(CC1)N(C)c1nc(N(C)CCC#N)c2sccc2n1
Show InChI InChI=1S/C20H30N6S/c1-15(2)14-26-11-6-16(7-12-26)25(4)20-22-17-8-13-27-18(17)19(23-20)24(3)10-5-9-21/h8,13,15-16H,5-7,10-12,14H2,1-4H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539961
PNG
(CHEMBL4642415)
Show SMILES CN(C)CCCN(C)c1nccc(n1)N(C)CCC#N
Show InChI InChI=1S/C14H24N6/c1-18(2)10-6-12-20(4)14-16-9-7-13(17-14)19(3)11-5-8-15/h7,9H,5-6,10-12H2,1-4H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539960
PNG
(CHEMBL4644148)
Show SMILES CN(C)CCCN(C)c1nc(N(C)CCC#N)c2n(C)cnc2n1
Show InChI InChI=1S/C16H26N8/c1-21(2)9-7-11-23(4)16-19-14-13(24(5)12-18-14)15(20-16)22(3)10-6-8-17/h12H,6-7,9-11H2,1-5H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539959
PNG
(CHEMBL4643929)
Show SMILES CN(C)CCCN(C)c1nc(N(C)CCC#N)c2cccnc2n1
Show InChI InChI=1S/C17H25N7/c1-22(2)11-7-13-24(4)17-20-15-14(8-5-10-19-15)16(21-17)23(3)12-6-9-18/h5,8,10H,6-7,11-13H2,1-4H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair
Glycylpeptide N-tetradecanoyltransferase 1


(Homo sapiens (Human))		BDBM50539957
PNG
(CHEMBL4649163)
Show SMILES CN(C)CCCN(C)c1nc(N(C)CCC#N)c2sccc2n1
Show InChI InChI=1S/C16H24N6S/c1-20(2)9-6-11-22(4)16-18-13-7-12-23-14(13)15(19-16)21(3)10-5-8-17/h7,12H,5-6,9-11H2,1-4H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Imperial College London

Curated by ChEMBL


Assay Description
Inhibition of human NMT1 using p60 SRC(2 to 16) as substrate by CPM dye based fluorescence assay

J Med Chem 63: 7740-7765 (2020)


Article DOI: 10.1021/acs.jmedchem.0c00570
BindingDB Entry DOI: 10.7270/Q2HX1H6V
More data for this
Ligand-Target Pair