| Reaction Details |
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 | Report a problem with these data |
| Target | Glycylpeptide N-tetradecanoyltransferase 1 |
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| Ligand | BDBM50539991 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1979910 (CHEMBL4613045) |
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| IC50 | 1700±n/a nM |
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| Citation |  Bell, AS; Yu, Z; Hutton, JA; Wright, MH; Brannigan, JA; Paape, D; Roberts, SM; Sutherell, CL; Ritzefeld, M; Wilkinson, AJ; Smith, DF; Leatherbarrow, RJ; Tate, EW Novel Thienopyrimidine Inhibitors of J Med Chem63:7740-7765 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycylpeptide N-tetradecanoyltransferase 1 |
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| Name: | Glycylpeptide N-tetradecanoyltransferase 1 |
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| Synonyms: | Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 56814.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30419 |
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| Residue: | 496 |
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| Sequence: | MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKK
QKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFW
DTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENY
VEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEK
KMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRS
LNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQF
HLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAY
SFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYN
WKCPSMGAEKVGLVLQ
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| BDBM50539991 |
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| n/a |
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| Name | BDBM50539991 |
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| Synonyms: | CHEMBL4632704 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H34N8O2S |
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| Mol. Mass. | 486.633 |
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| SMILES | CCN(C)c1nc(nc2ccc(cc12)S(=O)(=O)Nc1c(C)nn(C)c1C)N(C)C1CCNCC1 |
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| Structure | 
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