BindingDB PrimarySearch

Found 16 hits with Last Name = 'ziebell' and Initial = 'mr'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Acetylcholine receptor subunit alpha/beta/delta/gamma (Torpedo californica)	BDBM50125936 (3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholine receptor subunit alpha/beta/delta/gamma (MOUSE-Mus musculus)	BDBM50125934 (3-(1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Receptor (3 oocytes)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Acetylcholine receptor subunit alpha/beta/delta/gamma (Torpedo californica)	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-[125I]-A-85,380 binding to alpha2 beta4 nicotinic acetylcholine receptor (nAChR) in rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Acetylcholine receptor subunit alpha/beta/delta/gamma (MOUSE-Mus musculus)	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Receptor (3 oocytes)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125939 (3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.63E+4	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125936 (3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+5	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125937 (3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES CCOC(=O)c1cncn1[C@@H](C)c1ccccc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.95E+5	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	5.77E+5	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Inhibition of currents elicited by GABA at EC5 (6-12 uM)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125937 (3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES CCOC(=O)c1cncn1[C@@H](C)c1ccccc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.70E+4	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Enhancement of currents elicited by GABA at EC5 (6-12 uM)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125939 (3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Enhancement of currents elicited by GABA at EC5 (6-12 uM)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125936 (3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Direct activation of Gamma-aminobutyric acid A receptor in the absence of GABA				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Ability to enhance currents from alpha-1-beta-2-gamma-2L-subunit of GABA receptor elicited by low concentrations of GABA				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125936 (3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125935 ((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...) Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1 \|r\| Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	6.40E+4	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Enhancement of currents elicited by GABA at EC5 (6-12 uM)				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2 (Homo sapiens (Human))	BDBM50125936 (3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.70E+4	n/a	n/a	n/a	n/a
Massachusetts General Hospital Curated by ChEMBL					Assay Description Direct activation of Gamma-aminobutyric acid A receptor in the absence of GABA				J Med Chem 46: 1257-65 (2003) Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ
Massachusetts General Hospital Curated by ChEMBL					More data for this Ligand-Target Pair