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Compile Data Set for Download or QSAR

Found 452 hits with Last Name = 'thomas-tran' and Initial = 'r'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5'-nucleotidase


(Homo sapiens (Human))
BDBM50527134
PNG
(CHEMBL4471306 | US20230295213, Compound a)
Show SMILES C[C@H](Nc1cc(Cl)nc2n(ncc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O)c1ccccc1F |r|
Show InChI InChI=1S/C20H24ClFN4O9P2/c1-10(11-4-2-3-5-13(11)22)24-14-6-16(21)25-19-12(14)7-23-26(19)20-18(28)17(27)15(35-20)8-34-37(32,33)9-36(29,30)31/h2-7,10,15,17-18,20,27-28H,8-9H2,1H3,(H,24,25)(H,32,33)(H2,29,30,31)/t10-,15+,17+,18+,20+/m0/s1
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0.00500n/an/an/an/an/an/an/an/a



Arcus Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-terminal His-tagged CD73 (27 to 549 residues) expressed in HEK293 cells using AMP as substrate preincubated for 1 h...


J Med Chem 63: 3935-3955 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01713
BindingDB Entry DOI: 10.7270/Q2G1648T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
5'-nucleotidase


(Homo sapiens (Human))
BDBM18136
PNG
(ADP, alpha beta-me | AMPCPP | [({[(2R,3S,4R,5R)-5-...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)CP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Show InChI InChI=1S/C11H17N5O9P2/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(25-11)1-24-27(22,23)4-26(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1
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88n/an/an/an/an/an/an/an/a



Arcus Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human CD73


J Med Chem 63: 3935-3955 (2020)


Article DOI: 10.1021/acs.jmedchem.9b01713
BindingDB Entry DOI: 10.7270/Q2G1648T
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546764
PNG
(CHEMBL4740423)
Show SMILES CC(C)c1cc(ccc1C(O)=O)-c1c(N)nn2ccc(nc12)-c1cc2CN([C@@H](C)C3CC3)C(=O)c2c(c1)C(F)(F)F |r|
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TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561856
PNG
(CHEMBL4749505)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3cc(C)c(C(O)=O)c(c3)C3CC3)c2c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561885
PNG
(CHEMBL4740643)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)C(F)(F)F)-c1cnc2[nH]cc(-c3ccc(C(O)=O)c(C)c3)c2c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546759
PNG
(CHEMBL4778393)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(NS(C)(=O)=O)c2C1=O)-c1ccn2nc(NC(C)=O)cc2n1 |r|
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n/an/a 1.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561884
PNG
(CHEMBL4758027)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(C)(=O)=O)-c1cnc2[nH]cc(-c3cnn(C)c3)c2c1 |r|
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n/an/a 1.5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561859
PNG
(CHEMBL4781463)
Show SMILES COc1cc(ccc1C(O)=O)-c1c[nH]c2ncc(cc12)-c1cc2CN([C@@H](C)C3CC3)C(=O)c2c(C)c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561854
PNG
(CHEMBL4794110)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(C(O)=O)c(c3)C3CC3)c2c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561858
PNG
(CHEMBL4744413)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(C(O)=O)c(c3)C(F)(F)F)c2c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546730
PNG
(CHEMBL4782083)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)C(F)(F)F)-c1ccn2nc(N)c(-c3cnn(C)c3)c2n1 |r|
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n/an/a 1.90n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546765
PNG
(CHEMBL4742062)
Show SMILES CC(C)c1cc(ccc1C(O)=O)-c1cnn2ccc(nc12)-c1cc2CN([C@@H](C)C3CC3)C(=O)c2c(c1)C(F)(F)F |r|
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n/an/a 2.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561853
PNG
(CHEMBL4754968)
Show SMILES CC(C)c1cc(ccc1C(O)=O)-c1c[nH]c2ncc(cc12)-c1cc2CN([C@@H](C)C3CC3)C(=O)c2c(C)c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546758
PNG
(CHEMBL4743121)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1ccn2nc(N)c(-c3ccc(CC(O)=O)cc3)c2n1 |r|
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TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561889
PNG
(CHEMBL4761831)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(cc3)C(C)(C)C(O)=O)c2c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546729
PNG
(CHEMBL4785086)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)C(F)(F)F)-c1ccn2nc(NC(C)=O)cc2n1 |r|
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TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546757
PNG
(CHEMBL4762555)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1ccn2nc(N)c(-c3ccc(C(O)=O)c(C)c3)c2n1 |r|
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TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561855
PNG
(CHEMBL4746279)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3cc(C)c(C(O)=O)c(C)c3)c2c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561878
PNG
(CHEMBL4748899)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)C(F)(F)F)-c1cnc2[nH]cc(-c3cnn(C)c3)c2c1 |r|
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n/an/a 2.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561876
PNG
(CHEMBL4752613)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(Cl)c2C1=O)-c1cnc2[nH]cc(-c3cnn(C)c3)c2c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561880
PNG
(CHEMBL4764811)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(NC(C)=O)c2C1=O)-c1cnc2[nH]cc(-c3cnn(C)c3)c2c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561851
PNG
(CHEMBL4751253)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(cc3)C(O)=O)c2c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561864
PNG
(CHEMBL4746409)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(cc3)C(N)=O)c2c1 |r|
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TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561882
PNG
(CHEMBL4756678)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)S(=O)(=O)N(C)C)-c1cnc2[nH]cc(-c3cnn(C)c3)c2c1 |r|
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n/an/a 2.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561887
PNG
(CHEMBL4756242)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(CC(O)=O)cc3)c2c1 |r|
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n/an/a 2.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561861
PNG
(CHEMBL4753736)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3cccc(c3)C(O)=O)c2c1 |r|
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n/an/a 2.70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546760
PNG
(CHEMBL4759380)
Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1ccn2nc(NC(C)=O)cc2n1 |r|
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n/an/a 2.70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561852
PNG
(CHEMBL4742698)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(C(O)=O)c(C)c3)c2c1 |r|
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n/an/a 2.80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561886
PNG
(CHEMBL4759357)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)C(F)(F)F)-c1cnc2[nH]cc(-c3cc(C)c(C(O)=O)c(C)c3)c2c1 |r|
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n/an/a 2.80n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546750
PNG
(CHEMBL4789901)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1ccc2nc(NC(=O)N3CCC[C@H]3C(N)=O)cn2n1 |r|
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n/an/a 2.90n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546728
PNG
(CHEMBL4755842)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1ccn2nc(N)c(-c3cnn(C)c3)c2n1 |r|
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n/an/a 2.90n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561857
PNG
(CHEMBL4797477)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(C(O)=O)c(F)c3)c2c1 |r|
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n/an/a 3.10n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561841
PNG
(CHEMBL4756533)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(nc3)C(C)(C)O)c2c1 |r|
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n/an/a 3.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561846
PNG
(CHEMBL4752612)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3cnn(C)c3)c2c1 |r|
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n/an/a 3.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561888
PNG
(CHEMBL4753632)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(CC(O)=O)c(C)c3)c2c1 |r|
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n/an/a 3.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561890
PNG
(CHEMBL4784640)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(cc3)C3(CC3)C(O)=O)c2c1 |r|
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n/an/a 3.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561837
PNG
(CHEMBL4779873)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccncc3)c2c1 |r|
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n/an/a 3.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50274640
PNG
(CHEMBL4126445)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1sc(NC(C)=O)nc1C |r|
Show InChI InChI=1S/C20H23N3O2S/c1-10-7-15(18-11(2)21-20(26-18)22-13(4)24)8-16-9-23(19(25)17(10)16)12(3)14-5-6-14/h7-8,12,14H,5-6,9H2,1-4H3,(H,21,22,24)/t12-/m0/s1
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Article
PubMed
n/an/a 3.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561891
PNG
(CHEMBL4752079)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(c2C1=O)C(F)(F)F)-c1cnc2[nH]cc(-c3ccc(cc3)C3(CC3)C(O)=O)c2c1 |r|
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n/an/a 3.60n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561877
PNG
(CHEMBL4793742)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C#N)c2C1=O)-c1cnc2[nH]cc(-c3cnn(C)c3)c2c1 |r|
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n/an/a 3.70n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561860
PNG
(CHEMBL4783418)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(C(O)=O)c(c3)N3CCCC3)c2c1 |r|
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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561881
PNG
(CHEMBL4744874)
Show SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1cnc2[nH]cc(-c3cnn(C)c3)c2c1 |r|
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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561883
PNG
(CHEMBL4776747)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(NS(C)(=O)=O)c2C1=O)-c1cnc2[nH]cc(-c3cnn(C)c3)c2c1 |r|
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n/an/a 4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561874
PNG
(CHEMBL4746404)
Show SMILES CC(C)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1cnc2[nH]cc(-c3cnn(C)c3)c2c1 |r|
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n/an/a 4.20n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561875
PNG
(CHEMBL4782819)
Show SMILES COc1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1cnc2[nH]cc(-c3cnn(C)c3)c2c1 |r|
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n/an/a 4.30n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546742
PNG
(CHEMBL4784554)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1ccn2nc(NC(C)=O)cc2n1 |r|
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n/an/a 4.40n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561850
PNG
(CHEMBL4754555)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(C(=O)NC3CCOCC3)c2c1 |r|
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n/an/a 4.5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561865
PNG
(CHEMBL4757598)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(cc3)S(N)(=O)=O)c2c1 |r|
PDB
MMDB

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UniProtKB/SwissProt

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DrugBank
antibodypedia
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50561862
PNG
(CHEMBL4792363)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1cnc2[nH]cc(-c3ccc(C)c(c3)C(O)=O)c2c1 |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of PI3K p120gamma (unknown origin) using phosphatidylinositol 4,5-bisphosphate as substrate in presence of ATP incubated for 60 mins by AD...


Citation and Details

Article DOI: 10.1021/acsmedchemlett.0c00387
BindingDB Entry DOI: 10.7270/Q2H70KHF
More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50546738
PNG
(CHEMBL4764627)
Show SMILES C[C@@H](C1CC1)N1Cc2cc(cc(C)c2C1=O)-c1ccc2nc(NC(C)=O)cn2n1 |r|
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.5n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of recombinant N-terminal His-tagged full-length human PI3K p120gamma expressed in Sf9 insect cells using phosphatidylinositol 4,5-bisphos...


Citation and Details

Article DOI: 10.1021/acs.jmedchem.0c01203
BindingDB Entry DOI: 10.7270/Q2K35Z80
More data for this
Ligand-Target Pair
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