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Compile Data Set for Download or QSAR

Found 224 hits with Last Name = 'saario' and Initial = 'sm'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295654
PNG
(CHEMBL559034 | Dodecylcarbamic acid 3-(1,2,3-thiad...)
Show SMILES CCCCCCCCCCCCNC(=O)Oc1cccc(c1)-c1csnn1
Show InChI InChI=1S/C21H31N3O2S/c1-2-3-4-5-6-7-8-9-10-11-15-22-21(25)26-19-14-12-13-18(16-19)20-17-27-24-23-20/h12-14,16-17H,2-11,15H2,1H3,(H,22,25)
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n/an/a 0.240n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50298655
PNG
(3-(4,5-Dihydrooxazol-2-yl)phenyl cyclohexylcarbama...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)C1=NCCO1 |t:18|
Show InChI InChI=1S/C16H20N2O3/c19-16(18-13-6-2-1-3-7-13)21-14-8-4-5-12(11-14)15-17-9-10-20-15/h4-5,8,11,13H,1-3,6-7,9-10H2,(H,18,19)
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n/an/a 1.20n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat brain assessed as by liquid scintillation counting


Eur J Med Chem 44: 4179-91 (2009)


Article DOI: 10.1016/j.ejmech.2009.05.012
BindingDB Entry DOI: 10.7270/Q2FT8M3R
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM26739
PNG
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
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n/an/a 3.80n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM26739
PNG
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
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n/an/a 3.80n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of Wistar rat brain FAAH


J Med Chem 49: 4650-6 (2006)


Article DOI: 10.1021/jm060394q
BindingDB Entry DOI: 10.7270/Q2Q52P8G
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295649
PNG
(3-Methoxy-4-(hexylcarbamoyloxy)benzoic acid methyl...)
Show SMILES CCCCCCNC(=O)Oc1ccc(cc1OC)C(=O)OC
Show InChI InChI=1S/C16H23NO5/c1-4-5-6-7-10-17-16(19)22-13-9-8-12(15(18)21-3)11-14(13)20-2/h8-9,11H,4-7,10H2,1-3H3,(H,17,19)
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n/an/a 5.5n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295660
PNG
(CHEMBL557234 | Dodecylcarbamic acid 4-(4,5-dihydro...)
Show SMILES CCCCCCCCCCCCNC(=O)Oc1ccc(cc1)C1=NCCS1 |t:23|
Show InChI InChI=1S/C22H34N2O2S/c1-2-3-4-5-6-7-8-9-10-11-16-24-22(25)26-20-14-12-19(13-15-20)21-23-17-18-27-21/h12-15H,2-11,16-18H2,1H3,(H,24,25)
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n/an/a 6.30n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50298666
PNG
((S)-3-(5-Methyl-4,5-dihydrooxazol-2-yl)phenylcyclo...)
Show SMILES C[C@H]1CN=C(O1)c1cccc(OC(=O)NC2CCCCC2)c1 |r,c:3|
Show InChI InChI=1S/C17H22N2O3/c1-12-11-18-16(21-12)13-6-5-9-15(10-13)22-17(20)19-14-7-3-2-4-8-14/h5-6,9-10,12,14H,2-4,7-8,11H2,1H3,(H,19,20)/t12-/m0/s1
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n/an/a 6.80n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat brain assessed as by liquid scintillation counting


Eur J Med Chem 44: 4179-91 (2009)


Article DOI: 10.1016/j.ejmech.2009.05.012
BindingDB Entry DOI: 10.7270/Q2FT8M3R
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295652
PNG
(CHEMBL551594 | n-Butylcarbamic acid 3-(1,2,3-thiad...)
Show SMILES CCCCNC(=O)Oc1cccc(c1)-c1csnn1
Show InChI InChI=1S/C13H15N3O2S/c1-2-3-7-14-13(17)18-11-6-4-5-10(8-11)12-9-19-16-15-12/h4-6,8-9H,2-3,7H2,1H3,(H,14,17)
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n/an/a 6.90n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295659
PNG
(CHEMBL560119 | n-Hexylcarbamic acid 4-(4,5-dihydro...)
Show SMILES CCCCCCNC(=O)Oc1ccc(cc1)C1=NCCS1 |t:17|
Show InChI InChI=1S/C16H22N2O2S/c1-2-3-4-5-10-18-16(19)20-14-8-6-13(7-9-14)15-17-11-12-21-15/h6-9H,2-5,10-12H2,1H3,(H,18,19)
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n/an/a 8.20n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM26134
PNG
((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
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n/an/a 9.10n/an/an/an/a7.437



University of Oxford



Assay Description
[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50298664
PNG
((S)-Methyl 2-(3-(cyclohexylcarbamoyloxy)phenyl)-4,...)
Show SMILES COC(=O)[C@@H]1COC(=N1)c1cccc(OC(=O)NC2CCCCC2)c1 |r,c:7|
Show InChI InChI=1S/C18H22N2O5/c1-23-17(21)15-11-24-16(20-15)12-6-5-9-14(10-12)25-18(22)19-13-7-3-2-4-8-13/h5-6,9-10,13,15H,2-4,7-8,11H2,1H3,(H,19,22)/t15-/m0/s1
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n/an/a 9.40n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat brain assessed as by liquid scintillation counting


Eur J Med Chem 44: 4179-91 (2009)


Article DOI: 10.1016/j.ejmech.2009.05.012
BindingDB Entry DOI: 10.7270/Q2FT8M3R
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50442954
PNG
(CHEMBL3087192)
Show SMILES COc1nn([C@@H](C)c2ccc(CC(C)C)cc2)c(=O)o1 |r|
Show InChI InChI=1S/C15H20N2O3/c1-10(2)9-12-5-7-13(8-6-12)11(3)17-15(18)20-14(16-17)19-4/h5-8,10-11H,9H2,1-4H3/t11-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50442946
PNG
(CHEMBL3087191)
Show SMILES COc1nn(C(C)c2ccc(cc2)N(c2ccccc2)c2ccccc2)c(=O)o1
Show InChI InChI=1S/C23H21N3O3/c1-17(26-23(27)29-22(24-26)28-2)18-13-15-21(16-14-18)25(19-9-5-3-6-10-19)20-11-7-4-8-12-20/h3-17H,1-2H3
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n/an/a 11n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat RBL2H3 cells assessed as blockade of [3H]-anandamide uptake incubated for 15 mins prior to [3H]-anandamide addition measure...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50442954
PNG
(CHEMBL3087192)
Show SMILES COc1nn([C@@H](C)c2ccc(CC(C)C)cc2)c(=O)o1 |r|
Show InChI InChI=1S/C15H20N2O3/c1-10(2)9-12-5-7-13(8-6-12)11(3)17-15(18)20-14(16-17)19-4/h5-8,10-11H,9H2,1-4H3/t11-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295656
PNG
(CHEMBL569368 | dodecylcarbamic acid 4-(1,2,3-thiad...)
Show SMILES CCCCCCCCCCCCNC(=O)Oc1ccc(cc1)-c1csnn1
Show InChI InChI=1S/C21H31N3O2S/c1-2-3-4-5-6-7-8-9-10-11-16-22-21(25)26-19-14-12-18(13-15-19)20-17-27-24-23-20/h12-15,17H,2-11,16H2,1H3,(H,22,25)
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n/an/a 12n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50298654
PNG
(3-(4,5-Dihydrooxazol-2-yl)phenyl cyclopentylcarbam...)
Show SMILES O=C(NC1CCCC1)Oc1cccc(c1)C1=NCCO1 |t:17|
Show InChI InChI=1S/C15H18N2O3/c18-15(17-12-5-1-2-6-12)20-13-7-3-4-11(10-13)14-16-8-9-19-14/h3-4,7,10,12H,1-2,5-6,8-9H2,(H,17,18)
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n/an/a 13n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat brain assessed as by liquid scintillation counting


Eur J Med Chem 44: 4179-91 (2009)


Article DOI: 10.1016/j.ejmech.2009.05.012
BindingDB Entry DOI: 10.7270/Q2FT8M3R
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM26143
PNG
(Alkenylboronic Acid, 22 | [(E)-2-(4-phenylphenyl)e...)
Show SMILES OB(O)\C=C\c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C14H13BO2/c16-15(17)11-10-12-6-8-14(9-7-12)13-4-2-1-3-5-13/h1-11,16-17H/b11-10+
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n/an/a 14n/an/an/an/a7.437



University of Oxford



Assay Description
[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50298660
PNG
((R)-3-(4-Methyl-4,5-dihydrooxazol-2-yl)phenylcyclo...)
Show SMILES C[C@@H]1COC(=N1)c1cccc(OC(=O)NC2CCCCC2)c1 |r,c:4|
Show InChI InChI=1S/C17H22N2O3/c1-12-11-21-16(18-12)13-6-5-9-15(10-13)22-17(20)19-14-7-3-2-4-8-14/h5-6,9-10,12,14H,2-4,7-8,11H2,1H3,(H,19,20)/t12-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat brain assessed as by liquid scintillation counting


Eur J Med Chem 44: 4179-91 (2009)


Article DOI: 10.1016/j.ejmech.2009.05.012
BindingDB Entry DOI: 10.7270/Q2FT8M3R
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50350547
PNG
(CHEMBL257307)
Show SMILES CCCCCCCCCCCC(=O)c1nc2ncccc2o1
Show InChI InChI=1S/C18H26N2O2/c1-2-3-4-5-6-7-8-9-10-12-15(21)18-20-17-16(22-18)13-11-14-19-17/h11,13-14H,2-10,12H2,1H3
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n/an/a 17n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50350547
PNG
(CHEMBL257307)
Show SMILES CCCCCCCCCCCC(=O)c1nc2ncccc2o1
Show InChI InChI=1S/C18H26N2O2/c1-2-3-4-5-6-7-8-9-10-12-15(21)18-20-17-16(22-18)13-11-14-19-17/h11,13-14H,2-10,12H2,1H3
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n/an/a 17n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295682
PNG
(4-(1,2,3-thiadiazol-4-yl)phenyl hexylcarbamate | C...)
Show SMILES CCCCCCNC(=O)Oc1ccc(cc1)-c1csnn1
Show InChI InChI=1S/C15H19N3O2S/c1-2-3-4-5-10-16-15(19)20-13-8-6-12(7-9-13)14-11-21-18-17-14/h6-9,11H,2-5,10H2,1H3,(H,16,19)
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n/an/a 19n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295683
PNG
(CHEMBL557505 | Cyclopentylcarbamic acid 4-(1,2,3-t...)
Show SMILES O=C(NC1CCCC1)Oc1ccc(cc1)-c1csnn1
Show InChI InChI=1S/C14H15N3O2S/c18-14(15-11-3-1-2-4-11)19-12-7-5-10(6-8-12)13-9-20-17-16-13/h5-9,11H,1-4H2,(H,15,18)
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n/an/a 20n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM26132
PNG
((4-phenylphenyl)boranediol | Phenylboronic Acid, 1...)
Show SMILES OB(O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C12H11BO2/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9,14-15H
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n/an/a 21n/an/an/an/a7.437



University of Oxford



Assay Description
[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295684
PNG
(CHEMBL551719 | Cyclohexylcarbamic acid 4-(1,2,3-th...)
Show SMILES O=C(NC1CCCCC1)Oc1ccc(cc1)-c1csnn1
Show InChI InChI=1S/C15H17N3O2S/c19-15(16-12-4-2-1-3-5-12)20-13-8-6-11(7-9-13)14-10-21-18-17-14/h6-10,12H,1-5H2,(H,16,19)
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n/an/a 21n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50442959
PNG
(CHEMBL3087182)
Show SMILES COc1nn(C(C)c2ccc(CC(C)C)cc2)c(=O)o1
Show InChI InChI=1S/C15H20N2O3/c1-10(2)9-12-5-7-13(8-6-12)11(3)17-15(18)20-14(16-17)19-4/h5-8,10-11H,9H2,1-4H3
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n/an/a 23n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50442953
PNG
(CHEMBL3087168)
Show SMILES COc1nn([C@@H](C)c2ccc(cc2)-c2ccccc2)c(=O)o1 |r|
Show InChI InChI=1S/C17H16N2O3/c1-12(19-17(20)22-16(18-19)21-2)13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-12H,1-2H3/t12-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50442959
PNG
(CHEMBL3087182)
Show SMILES COc1nn(C(C)c2ccc(CC(C)C)cc2)c(=O)o1
Show InChI InChI=1S/C15H20N2O3/c1-10(2)9-12-5-7-13(8-6-12)11(3)17-15(18)20-14(16-17)19-4/h5-8,10-11H,9H2,1-4H3
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n/an/a 23n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50442953
PNG
(CHEMBL3087168)
Show SMILES COc1nn([C@@H](C)c2ccc(cc2)-c2ccccc2)c(=O)o1 |r|
Show InChI InChI=1S/C17H16N2O3/c1-12(19-17(20)22-16(18-19)21-2)13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-12H,1-2H3/t12-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295651
PNG
(3-Iodo-4-(hexylcarbamoyloxy)benzoic acid methyl es...)
Show SMILES CCCCCCNC(=O)Oc1ccc(cc1I)C(=O)OC
Show InChI InChI=1S/C15H20INO4/c1-3-4-5-6-9-17-15(19)21-13-8-7-11(10-12(13)16)14(18)20-2/h7-8,10H,3-6,9H2,1-2H3,(H,17,19)
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n/an/a 24n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50218953
PNG
(3-(benzo[d]oxazole-2-carbonyl)phenyl cyclopentylca...)
Show SMILES O=C(NC1CCCC1)Oc1cccc(c1)C(=O)c1nc2ccccc2o1
Show InChI InChI=1S/C20H18N2O4/c23-18(19-22-16-10-3-4-11-17(16)26-19)13-6-5-9-15(12-13)25-20(24)21-14-7-1-2-8-14/h3-6,9-12,14H,1-2,7-8H2,(H,21,24)
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n/an/a 28n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH activity in Wistar rat brain


J Med Chem 50: 4236-42 (2007)


Article DOI: 10.1021/jm070501w
BindingDB Entry DOI: 10.7270/Q2DV1JKK
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50218944
PNG
(3-(benzo[d]oxazole-2-carbonyl)phenyl m-methylbenzy...)
Show SMILES Cc1cccc(CNC(=O)Oc2cccc(c2)C(=O)c2nc3ccccc3o2)c1
Show InChI InChI=1S/C23H18N2O4/c1-15-6-4-7-16(12-15)14-24-23(27)28-18-9-5-8-17(13-18)21(26)22-25-19-10-2-3-11-20(19)29-22/h2-13H,14H2,1H3,(H,24,27)
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n/an/a 32n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH activity in Wistar rat brain


J Med Chem 50: 4236-42 (2007)


Article DOI: 10.1021/jm070501w
BindingDB Entry DOI: 10.7270/Q2DV1JKK
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50298653
PNG
(3-(4,5-Dihydrooxazol-2-yl)phenyl propylcarbamate |...)
Show SMILES CCCNC(=O)Oc1cccc(c1)C1=NCCO1 |t:14|
Show InChI InChI=1S/C13H16N2O3/c1-2-6-15-13(16)18-11-5-3-4-10(9-11)12-14-7-8-17-12/h3-5,9H,2,6-8H2,1H3,(H,15,16)
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n/an/a 33n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat brain assessed as by liquid scintillation counting


Eur J Med Chem 44: 4179-91 (2009)


Article DOI: 10.1016/j.ejmech.2009.05.012
BindingDB Entry DOI: 10.7270/Q2FT8M3R
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295680
PNG
((2-Methyl)-benzylcarbamic acid 4-(4,5-dihydrooxazo...)
Show SMILES Cc1ccccc1CNC(=O)Oc1ccc(cc1)C1=NCCO1 |t:20|
Show InChI InChI=1S/C18H18N2O3/c1-13-4-2-3-5-15(13)12-20-18(21)23-16-8-6-14(7-9-16)17-19-10-11-22-17/h2-9H,10-12H2,1H3,(H,20,21)
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n/an/a 34n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50442947
PNG
(CHEMBL3087185)
Show SMILES COc1nn(C(C)c2ccc(Oc3ccccc3)cc2)c(=O)o1
Show InChI InChI=1S/C17H16N2O4/c1-12(19-17(20)23-16(18-19)21-2)13-8-10-15(11-9-13)22-14-6-4-3-5-7-14/h3-12H,1-2H3
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n/an/a 34n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50442947
PNG
(CHEMBL3087185)
Show SMILES COc1nn(C(C)c2ccc(Oc3ccccc3)cc2)c(=O)o1
Show InChI InChI=1S/C17H16N2O4/c1-12(19-17(20)23-16(18-19)21-2)13-8-10-15(11-9-13)22-14-6-4-3-5-7-14/h3-12H,1-2H3
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n/an/a 34n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM26129
PNG
(CHEMBL143654 | Phenylboronic Acid, 8 | [4-(trifluo...)
Show SMILES OB(O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C7H6BF3O2/c9-7(10,11)5-1-3-6(4-2-5)8(12)13/h1-4,12-13H
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n/an/a 36n/an/an/an/a7.437



University of Oxford



Assay Description
[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...


J Med Chem 51: 7057-60 (2008)


Article DOI: 10.1021/jm801051t
BindingDB Entry DOI: 10.7270/Q25D8Q58
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295677
PNG
(CHEMBL557100 | Phenethylcarbamic acid 4-(4,5-dihyd...)
Show SMILES O=C(NCCc1ccccc1)Oc1ccc(cc1)C1=NCCS1 |t:20|
Show InChI InChI=1S/C18H18N2O2S/c21-18(20-11-10-14-4-2-1-3-5-14)22-16-8-6-15(7-9-16)17-19-12-13-23-17/h1-9H,10-13H2,(H,20,21)
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n/an/a 38n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50218941
PNG
(3-(benzo[d]thiazole-2-carbonyl)phenyl 3-methylbenz...)
Show SMILES Cc1cccc(CNC(=O)Oc2cccc(c2)C(=O)c2nc3ccccc3s2)c1
Show InChI InChI=1S/C23H18N2O3S/c1-15-6-4-7-16(12-15)14-24-23(27)28-18-9-5-8-17(13-18)21(26)22-25-19-10-2-3-11-20(19)29-22/h2-13H,14H2,1H3,(H,24,27)
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n/an/a 38n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH activity in Wistar rat brain


J Med Chem 50: 4236-42 (2007)


Article DOI: 10.1021/jm070501w
BindingDB Entry DOI: 10.7270/Q2DV1JKK
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295661
PNG
(Benzylcarbamic acid 4-(1,2,3-thiadiazol-4-yl)pheny...)
Show SMILES O=C(NCc1ccccc1)Oc1ccc(cc1)-c1csnn1
Show InChI InChI=1S/C16H13N3O2S/c20-16(17-10-12-4-2-1-3-5-12)21-14-8-6-13(7-9-14)15-11-22-19-18-15/h1-9,11H,10H2,(H,17,20)
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n/an/a 44n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50298657
PNG
(3-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)phenylcyclo...)
Show SMILES CC1(C)COC(=N1)c1cccc(OC(=O)NC2CCCCC2)c1 |c:5|
Show InChI InChI=1S/C18H24N2O3/c1-18(2)12-22-16(20-18)13-7-6-10-15(11-13)23-17(21)19-14-8-4-3-5-9-14/h6-7,10-11,14H,3-5,8-9,12H2,1-2H3,(H,19,21)
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n/an/a 46n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat brain assessed as by liquid scintillation counting


Eur J Med Chem 44: 4179-91 (2009)


Article DOI: 10.1016/j.ejmech.2009.05.012
BindingDB Entry DOI: 10.7270/Q2FT8M3R
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50218950
PNG
(3-(benzo[d]oxazole-2-carbonyl)phenyl cyclohexylcar...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)C(=O)c1nc2ccccc2o1
Show InChI InChI=1S/C21H20N2O4/c24-19(20-23-17-11-4-5-12-18(17)27-20)14-7-6-10-16(13-14)26-21(25)22-15-8-2-1-3-9-15/h4-7,10-13,15H,1-3,8-9H2,(H,22,25)
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n/an/a 47n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH activity in Wistar rat brain


J Med Chem 50: 4236-42 (2007)


Article DOI: 10.1021/jm070501w
BindingDB Entry DOI: 10.7270/Q2DV1JKK
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50442958
PNG
(CHEMBL3087183)
Show SMILES COc1nn(C(C)c2ccc(cc2)-c2ccccc2)c(=O)o1
Show InChI InChI=1S/C17H16N2O3/c1-12(19-17(20)22-16(18-19)21-2)13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-12H,1-2H3
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n/an/a 47n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50218952
PNG
(3-(benzo[d]thiazole-2-carbonyl)phenyl cyclopentylc...)
Show SMILES O=C(NC1CCCC1)Oc1cccc(c1)C(=O)c1nc2ccccc2s1
Show InChI InChI=1S/C20H18N2O3S/c23-18(19-22-16-10-3-4-11-17(16)26-19)13-6-5-9-15(12-13)25-20(24)21-14-7-1-2-8-14/h3-6,9-12,14H,1-2,7-8H2,(H,21,24)
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n/an/a 47n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH activity in Wistar rat brain


J Med Chem 50: 4236-42 (2007)


Article DOI: 10.1021/jm070501w
BindingDB Entry DOI: 10.7270/Q2DV1JKK
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))
BDBM50442958
PNG
(CHEMBL3087183)
Show SMILES COc1nn(C(C)c2ccc(cc2)-c2ccccc2)c(=O)o1
Show InChI InChI=1S/C17H16N2O3/c1-12(19-17(20)22-16(18-19)21-2)13-8-10-15(11-9-13)14-6-4-3-5-7-14/h3-12H,1-2H3
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n/an/a 48n/an/an/an/an/an/a



University of Eastern Finland

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FAAH overexpressed in African green monkey COS7 cells using [3H]-anandamide as substrate preincubated for 10 mins bef...


J Med Chem 56: 8484-96 (2013)


Article DOI: 10.1021/jm400923s
BindingDB Entry DOI: 10.7270/Q29C6ZWQ
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295653
PNG
(CHEMBL541753 | Dodecylcarbamic acid 2-(1,2,3-thiad...)
Show SMILES CCCCCCCCCCCCNC(=O)Oc1ccccc1-c1csnn1
Show InChI InChI=1S/C21H31N3O2S/c1-2-3-4-5-6-7-8-9-10-13-16-22-21(25)26-20-15-12-11-14-18(20)19-17-27-24-23-19/h11-12,14-15,17H,2-10,13,16H2,1H3,(H,22,25)
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n/an/a 50n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50298659
PNG
((S)-3-(4-Methyl-4,5-dihydrooxazol-2-yl)phenylcyclo...)
Show SMILES C[C@H]1COC(=N1)c1cccc(OC(=O)NC2CCCCC2)c1 |r,c:4|
Show InChI InChI=1S/C17H22N2O3/c1-12-11-21-16(18-12)13-6-5-9-15(10-13)22-17(20)19-14-7-3-2-4-8-14/h5-6,9-10,12,14H,2-4,7-8,11H2,1H3,(H,19,20)/t12-/m0/s1
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n/an/a 51n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat brain assessed as by liquid scintillation counting


Eur J Med Chem 44: 4179-91 (2009)


Article DOI: 10.1016/j.ejmech.2009.05.012
BindingDB Entry DOI: 10.7270/Q2FT8M3R
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50218943
PNG
(3-(benzo[d]oxazole-2-carbonyl)phenyl butylcarbamat...)
Show SMILES CCCCNC(=O)Oc1cccc(c1)C(=O)c1nc2ccccc2o1
Show InChI InChI=1S/C19H18N2O4/c1-2-3-11-20-19(23)24-14-8-6-7-13(12-14)17(22)18-21-15-9-4-5-10-16(15)25-18/h4-10,12H,2-3,11H2,1H3,(H,20,23)
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n/an/a 54n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH activity in Wistar rat brain


J Med Chem 50: 4236-42 (2007)


Article DOI: 10.1021/jm070501w
BindingDB Entry DOI: 10.7270/Q2DV1JKK
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295650
PNG
(3-methyl-4-(hexylcarbamoyloxy)benzoic acid methyl ...)
Show SMILES CCCCCCNC(=O)Oc1ccc(cc1C)C(=O)OC
Show InChI InChI=1S/C16H23NO4/c1-4-5-6-7-10-17-16(19)21-14-9-8-13(11-12(14)2)15(18)20-3/h8-9,11H,4-7,10H2,1-3H3,(H,17,19)
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n/an/a 55n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50218951
PNG
(3-(benzo[d]thiazole-2-carbonyl)phenyl cyclohexylca...)
Show SMILES O=C(NC1CCCCC1)Oc1cccc(c1)C(=O)c1nc2ccccc2s1
Show InChI InChI=1S/C21H20N2O3S/c24-19(20-23-17-11-4-5-12-18(17)27-20)14-7-6-10-16(13-14)26-21(25)22-15-8-2-1-3-9-15/h4-7,10-13,15H,1-3,8-9H2,(H,22,25)
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n/an/a 56n/an/an/an/an/an/a



Helsinki University of Technology

Curated by ChEMBL


Assay Description
Inhibition of FAAH activity in Wistar rat brain


J Med Chem 50: 4236-42 (2007)


Article DOI: 10.1021/jm070501w
BindingDB Entry DOI: 10.7270/Q2DV1JKK
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))
BDBM50295674
PNG
((2-Methyl)-benzylcarbamic acid 4-(4,5-dihydrothiaz...)
Show SMILES Cc1ccccc1CNC(=O)Oc1ccc(cc1)C1=NCCS1 |t:20|
Show InChI InChI=1S/C18H18N2O2S/c1-13-4-2-3-5-15(13)12-20-18(21)22-16-8-6-14(7-9-16)17-19-10-11-23-17/h2-9H,10-12H2,1H3,(H,20,21)
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n/an/a 62n/an/an/an/an/an/a



University of Kuopio

Curated by ChEMBL


Assay Description
Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation counting


Eur J Med Chem 44: 2994-3008 (2009)


Article DOI: 10.1016/j.ejmech.2009.01.007
BindingDB Entry DOI: 10.7270/Q2VT1S5S
More data for this
Ligand-Target Pair
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